[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606110":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":32,"locations":42,"responsibleParty":53,"collaborators":57,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":11,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":45,"whyStopped":11,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"German Institute of Human Nutrition","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Early Time-Restricted Eating","EXPERIMENTAL",null,[13],"Behavioral: Early Time-Restricted Eating",{"label":15,"type":10,"description":11,"interventionNames":16},"Late Time-Restricted Eating",[17],"Behavioral: Late Time-Restricted Eating",[19,26],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"BEHAVIORAL","Participants will restrict their eating window (8 hours eating and 16 hours fasting per day) and caloric intake moderately.\n\nDuring the early TRE intervention, participants will primarily consume their meals in the morning. The precise eating window will be defined based on the individual chronotype of the participants. Additionally, participants will be required to reduce their daily caloric consumption by 25%. They will replace one daily meal with a calorie-reduced product to facilitate caloric restriction.",[9],[24,25],"eTRE","early TRE",{"type":20,"name":15,"description":27,"armGroupLabels":28,"otherNames":29},"Participants will restrict their eating window (8 hours eating and 16 hours fasting per day) and caloric intake moderately.\n\nDuring the late TRE intervention, participants will primarily consume their meals in the evening. The precise eating window will be defined based on the individual chronotype of the participants. Additionally, participants will be required to reduce their daily caloric consumption by 25%. They will replace one daily meal with a calorie-reduced product to facilitate caloric restriction.",[15],[30,31],"LateTRE","lTRE",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":11,"email":37},"Olga Ramich, Prof. Dr.","CONTACT","+49 33200 882749","olga.ramich@dife.de",{"name":39,"role":35,"phone":40,"phoneExt":11,"email":41},"Bettina Schuppelius, M.Sc.","+49 33200 882692","bettina.schuppelius@dife.de",[43],{"facility":44,"status":45,"city":46,"state":11,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":11,"geoPoint":11,"contacts":50},"German Institute of Human Nutrition Potsdam-Rehbruecke","RECRUITING","Nuthetal","14558","Germany","DE",[51,52],{"name":34,"role":35,"phone":36,"phoneExt":11,"email":37},{"name":39,"role":35,"phone":40,"phoneExt":11,"email":41},{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Olga Ramich (formerly Pivovarova)","Head of Department Molecular Metabolism and Precision Nutrition",[58,60,63,65,67,69],{"name":59,"class":6},"Technische Universität Dresden",{"name":61,"class":62},"University of Surrey, UK","UNKNOWN",{"name":64,"class":6},"University of Geneva, Switzerland",{"name":66,"class":62},"Technische Universität München, Germany",{"name":68,"class":6},"German Center for Diabetes Research",{"name":70,"class":62},"University of Rovira i Virgili, Spain","100606110","precise-eating-time-to-improve-glycemic-control-and-cardiometabolic-health-in-prediabetes-and-diabetes-100606110",false,"NCT07171281","Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes","Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes: the GLYCOTIME Trial","GLYCOTIME","Inclusion Criteria:\n\n* Overweight or obesity (BMI 25-40 kg\u002Fm²)\n* Healthy glucose metabolism (fasting glucose \\\u003C100 mg\u002Fdl and glucose after 2 hours OGTT \\\u003C140 mg\u002Fdl)\n* OR impaired glucose metabolism (fasting glucose 100-125 mg\u002Fdl and\u002For glucose after 2 hours OGTT 140-199 mg\u002Fdl and\u002For HbA1c 5.7-6.4%)\n* OR type 2 diabetes (according to existing medical diagnosis or fasting glucose \\>126 mg\u002Fdl and\u002For glucose after 2 hours OGTT \\>200 mg\u002Fdl and\u002For HbA1c ≥6.5%)\n* Daily eating window ≥12 hours\n\nExclusion Criteria:\n\n* Weight changes \\> 5% within past 3 months\n* Shift work\n* Traveling across more than one time zone within one month prior to the study\n* Pregnancy and breastfeeding\n* Eating disorders, food intolerance\u002Fallergy to ingredients in the diet product, vegan diet, practicing time-restricted eating\n* Severe chronic illnesses or other conditions that are incompatible with the planned intervention and examination program (e.g. type 1 diabetes, recent cardiovascular event, malabsorption, cancer in the last two years, etc.)\n* Treatment with insulin, sulfonylureas, and GLP-1 receptor agonists, steroid use (oral, cutaneous, or parenteral), regular intake of melatonin, anticoagulation treatment that cannot be paused\n* Extreme early and extreme late chronotypes",true,"ALL","18 Years","75 Years",{"count":84,"type":85},30,"ESTIMATED","INTERVENTIONAL",[88],"NA","The objective of this study is to investigate the impact of hypocaloric time-restricted eating (TRE) at different day times (early versus late TRE) on glucose metabolism and other cardiometabolic parameters in individuals with overweight and with normal, or impaired glucose metabolism (prediabetes and type 2 diabetes). In addition, the study aims to elucidate the molecular mechanisms underlying these effects.",[91,92,93],"Prediabetes","Type 2 Diabetes","Obesity &Amp; Overweight",[95,91,92,96,97,98,99,100,101,102],"Time-restricted eating","Chrononutrition","Glucose metabolism","Overweight","Obesity","Continuous glucose monitoring","TRE","Prevention and treatment of type 2 diabetes","2025-09-10",{"date":105,"type":106},"2025-09-12","ACTUAL",{"date":108,"type":85},"2025-09-19",{"date":110,"type":85},"2028-02-28",{"name":5,"class":6},1]