[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603479":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":11,"locations":10,"responsibleParty":17,"collaborators":21,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":10,"eligibilityCriteria":41,"healthyVolunteers":37,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":48,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":10,"overallStatus":54,"whyStopped":10,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":10},{"fullName":5,"class":6},"The First Affiliated Hospital of Xiamen University","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":10},"68Ga-FAPI-LM3 & 68Ga-PD-L1 PET\u002FCT Imaging Evaluation Cohort",null,[12],{"name":13,"role":14,"phone":15,"phoneExt":10,"email":16},"Qin Lin, Doctor","CONTACT","+8613806000926","linqin05@163.com",{"type":18,"investigatorFullName":19,"investigatorTitle":20,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Lin Qin","Prof.",[22,24,26,28,30,32],{"name":23,"class":6},"Sun Yat-Sen University Cancer Center",{"name":25,"class":6},"Peking University Shenzhen Hospital",{"name":27,"class":6},"Sichuan Cancer Hospital and Research Institute",{"name":29,"class":6},"Shandong Cancer Hospital and Institute",{"name":31,"class":6},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology",{"name":33,"class":34},"Shenzhen Yino Intelligence Technology Development Co.,Ltd.","UNKNOWN","100603479","precise-guidance-of-adaptive-radiotherapy-for-nasopharyngeal-carcinomar-100603479",false,"NCT07137052","Precise Guidance of Adaptive Radiotherapy for Nasopharyngeal Carcinomar","A Prospective Multi-center Clinical Study on Precise Guidance of Adaptive Radiotherapy for Nasopharyngeal Carcinomar by Multi-dimensional Molecular Imaging","Inclusion Criteria:\n\n1. Any sex; age 18-70 years.\n2. Histologically confirmed non-keratinizing nasopharyngeal carcinoma (World Health Organization (WHO) type II or III).\n3. Clinical stage I-IVA (American Joint Committee on Cancer (AJCC)\u002FUnion for International Cancer Control (UICC) 8th edition) with no evidence of distant metastasis.\n4. Eastern Cooperative Oncology Group (ECOG) performance status 0-1.\n5. No prior anti-tumor treatment for nasopharyngeal carcinoma, including radiotherapy, chemotherapy, immunotherapy, or biologic therapy.\n6. No contraindications to radiotherapy or chemotherapy.\n7. Adequate major organ function as defined below:\n\n   7.1 Hematology: white blood cell (WBC) ≥ 4.0 × 10\\^9\u002FL, absolute neutrophil count (ANC) ≥ 1.5 × 10\\^9\u002FL, platelet count ≥ 100 × 10\\^9\u002FL, hemoglobin ≥ 90 g\u002FL (no blood transfusion or blood products within 14 days and no use of granulocyte colony-stimulating factor (G-CSF) or other hematopoietic growth factors to correct counts);\n\n   7.2 Biochemistry: alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × upper limit of normal (ULN); blood urea nitrogen (BUN) and serum creatinine ≤ 1.5 × ULN, or creatinine clearance ≥ 60 mL\u002Fmin calculated by the Cockcroft-Gault formula.\n8. Participant voluntarily agrees to join the study, signs informed consent, has good compliance, and is able to attend follow-up.\n\nExclusion Criteria:\n\n1. Pathological type of keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma.\n2. History of or concurrent other active (unresolved) malignant tumors, except for previously cured basal cell carcinoma of the skin, carcinoma in situ of the cervix, or superficial bladder cancer.\n3. Currently participating in another clinical trial.\n4. Pregnant or breastfeeding women.\n5. Uncontrolled cardiovascular disease, including ≥ Grade II myocardial ischemia or myocardial infarction, uncontrolled cardiac arrhythmias (including corrected QT (QTc) interval ≥ 470 ms); heart failure New York Heart Association (NYHA) class III-IV, or left ventricular ejection fraction (LVEF) \\\u003C 50% on echocardiography; or myocardial infarction within the past year.\n6. Other severe comorbidities such as uncontrolled hypertension, severe cerebrovascular disease, severe renal disease, uncontrolled diabetes mellitus, or other chronic wasting diseases.\n7. History of substance or alcohol abuse, psychiatric illness, or lack of full or having limited civil capacity.\n8. In the investigator's judgment, other familial or social factors that could force premature withdrawal from the study, or other conditions likely to affect participant safety or the collection of trial data.","ALL","18 Years","70 Years",{"count":46,"type":47},732,"ESTIMATED","3 Years","OBSERVATIONAL","This is an observational cohort study designed to (1) evaluate whether Gallium-68 (68Ga)-labeled fibroblast activation protein inhibitor ligand LM3 (68Ga-FAPI-LM3) positron emission tomography\u002Fcomputed tomography (PET\u002FCT) improves the accuracy of nasopharyngeal carcinoma (NPC) staging, and (2) determine whether Gallium-68-labeled programmed death-ligand 1 (68Ga-PD-L1) PET\u002FCT imaging parameters can provide early prediction of response to neoadjuvant immunotherapy. The study will assess the sensitivity and specificity of each tracer for staging and for predicting therapeutic response, analyze changes in tumor uptake parameters on 68Ga-FAPI-LM3 and 68Ga-PD-L1 PET\u002FCT before and after treatment, and compare treatment efficacy and survival outcomes between patients with different degrees of residual PET uptake and between those who did and did not receive neoadjuvant immunotherapy. The primary question it aims to answer is:\n\nDoes 68Ga-FAPI-LM3 PET\u002FCT improve the accuracy of NPC staging, and can 68Ga-PD-L1 PET\u002FCT imaging parameters provide an early prediction of response to neoadjuvant immunotherapy?\n\nParticipants will be patients with biopsy-proven nasopharyngeal carcinoma who undergo 68Ga-FAPI-LM3 and\u002For 68Ga-PD-L1 PET\u002FCT as part of clinical care or a research protocol. Tumor uptake metrics (e.g., maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic\u002Fvolumetric indices) will be measured pre- and post-treatment; diagnostic performance (sensitivity, specificity) and associations between uptake changes and clinical outcomes (response rates, progression-free and overall survival) will be calculated.",[52,53],"Nasopharyngeal Carcinoma (NPC)","PET \u002F CT","NOT_YET_RECRUITING","2025-09-16",{"date":57,"type":58},"2025-09-17","ACTUAL",{"date":60,"type":47},"2025-09-30",{"date":62,"type":47},"2029-01-30",{"name":5,"class":6}]