[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599717":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":71,"collaborators":25,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":25,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":25,"enrollmentInfo":84,"targetDuration":25,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":99,"whyStopped":25,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Rush University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Precision-Controlled Ventilation with Real-Time Feedback","EXPERIMENTAL","Patients will receive manual ventilation during CPR using real-time feedback devices (EOlife) to guide tidal volume (6-8 mL\u002Fkg predicted body weight) and ventilation rate (10 breaths per minute) delivery, ensuring adherence to guideline-recommended ventilation parameters.",[13],"Device: Precision-Controlled Ventilation with Real-Time Feedback",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of Care Ventilation During CPR","ACTIVE_COMPARATOR","Patients will receive manual ventilation during CPR per standard practice without real-time feedback, using clinician judgment for tidal volume (visible chest rise) and ventilation rate, consistent with American Heart Association guidelines.",[19],"Other: Standard Manual Ventilation During CPR",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Manual ventilation during CPR using a real-time feedback device (EOlife, Archeon Medical) to guide the delivery of tidal volumes (6-8 mL\u002Fkg predicted body weight) and ventilation rate (10 breaths per minute). The device measures and displays ventilation parameters in real time, helping providers achieve guideline-recommended targets during resuscitation.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Standard Manual Ventilation During CPR","Manual ventilation during CPR without real-time feedback, using clinician judgment to guide tidal volume (visible chest rise) and ventilation rate, consistent with American Heart Association guidelines.",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"JIE LI, PhD","CONTACT","13125634643","jie_li@rush.edu",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":39},"Brady Scott, PhD","(312) 942-6389","Jonathan_B_Scott@rush.edu",[41,56],{"facility":5,"status":25,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Chicago","Illinois","60612","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-87.65005,41.85003,{"lat":51,"lon":50},[54],{"name":32,"role":33,"phone":55,"phoneExt":25,"email":35},"312-563-4643",{"facility":57,"status":25,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Hospital Civil Fray Antonio Alcalde, University of Guadalajara","Guadalajara","Jalisco","44280","Mexico","MX",{"type":48,"coordinates":64},[65,66],-103.34749,20.67738,{"lat":66,"lon":65},[69],{"name":70,"role":33,"phone":25,"phoneExt":25,"email":25},"Miguel Ibarra-Estrada, MD",{"type":72,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Jie Li","Professor","100599717","precision-cpr-precision-controlled-ventilation-in-cpr-100599717",false,"NCT07088120","PRECISION-CPR: PRecision-Controlled Ventilation in CPR","PRecision-Controlled Ventilation to Enhance Cardiac Arrest Intervention and Survival IN CPR: A Multi-Center Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients (18 years or older) with in-hospital cardiac arrest receiving manual ventilation via bag-mask or artificial airway\n\nExclusion Criteria:\n\n* Inability to estimate predicted body weight (e.g., extreme body habitus or lack of height data).\n* Patients receiving Extracorporeal Membrane Oxygenation (ECMO).\n* Known pregnancy.","ALL","18 Years",{"count":85,"type":86},852,"ESTIMATED","INTERVENTIONAL",[89],"NA","Cardiac arrest is a life-threatening emergency that requires immediate treatment with cardiopulmonary resuscitation (CPR). While chest compressions circulate blood, manual ventilation provides oxygen to the patient. Current CPR guidelines recommend specific ventilation rates and tidal volumes, but studies show that clinicians often deliver too much or too little ventilation due to a lack of monitoring tools, potentially reducing the effectiveness of CPR and impacting survival.\n\nThe PRECISION-CPR study is a multi-center, randomized controlled trial designed to evaluate whether using real-time feedback devices to precisely control ventilation during CPR can improve patient outcomes. Adult patients experiencing in-hospital cardiac arrest will be randomized to receive either standard manual ventilation guided by clinician experience or precision-controlled ventilation tailored to the patient's predicted body weight using real-time monitoring devices.\n\nThe primary outcome of the study will be return of spontaneous circulation (ROSC). Secondary outcomes will include survival to hospital discharge, neurological recovery, and other clinical measures. By addressing the limitations of current ventilation practices, this study aims to generate evidence to guide future resuscitation guidelines and improve survival rates after cardiac arrest.",[92],"Cardiac Arrest (CA)",[94,95,96,97,98],"ventilation","tidal volume","cardiac pulmonary resuscitation","real-time feedback","Return of spontaneous circulation","NOT_YET_RECRUITING","2026-03-10",{"date":102,"type":103},"2026-03-11","ACTUAL",{"date":105,"type":86},"2026-09-01",{"date":107,"type":86},"2030-12-31",{"name":5,"class":6},2]