[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626230":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":27,"locations":35,"responsibleParty":52,"collaborators":54,"id":88,"slug":89,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":90,"sex":95,"minAge":96,"maxAge":10,"enrollmentInfo":97,"targetDuration":10,"studyType":100,"phases":10,"briefSummary":101,"conditions":102,"keywords":115,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"Royal Marsden NHS Foundation Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Prospective",null,"Prospective observational cohort study: a cohort of patients advancing directly to surgery (\"Control group\") and Prospective cohort receiving neo-adjuvant chemotherapy. Prospectively enrolled patients with STS, tissue samples pre-chemotherapy and from surgical resection will undergo epigenetic, proteomic and genomic profiling to define the biology at two distinct time points.",[13],"Other: Observational Translational Study",{"label":15,"type":10,"description":16,"interventionNames":17},"Retrospective","Retrospective cohort study: a cohort of patients who advanced directly to surgery (\"Control group\") and a cohort treated with NCT.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Observational Translational Study","Cohort study aimed at developing a stratified medicine approach for personalised neoadjuvant chemotherapy (NCT)",[9,15],[24],{"name":25,"affiliation":5,"role":26},"Robin Jones, MD","STUDY_DIRECTOR",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Stephanie Elston, MSc","CONTACT","02073528171","PANTHRS.Trial@rmh.nhs.uk",{"name":34,"role":30,"phone":31,"phoneExt":10,"email":32},"Thuy-Giang Nguyen, BSc",[36],{"facility":37,"status":38,"city":39,"state":10,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"The Royal Marsden Hospital","RECRUITING","London","SW3 6JJ","United Kingdom","UK",{"type":44,"coordinates":45},"Point",[46,47],-0.12574,51.50853,{"lat":47,"lon":46},[50],{"name":51,"role":30,"phone":31,"phoneExt":10,"email":32},"Stephanie Elston",{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[55,57,59,61,63,65,67,69,71,73,75,78,80,82,84,86],{"name":56,"class":6},"Institute of Cancer Research, United Kingdom",{"name":58,"class":6},"University of Edinburgh",{"name":60,"class":6},"NHS Greater Glasgow and Clyde",{"name":62,"class":6},"University of Birmingham",{"name":64,"class":6},"University Hospital Birmingham",{"name":66,"class":6},"Cancer Research UK",{"name":68,"class":6},"Fondazione IRCCS Istituto Nazionale dei Tumori, Milano",{"name":70,"class":6},"Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz",{"name":72,"class":6},"Hospitales Universitarios Virgen del Rocío",{"name":74,"class":6},"Andalusian Network for Design and Translation of Advanced Therapies",{"name":76,"class":77},"Instituto de Biomedicina de Sevilla","UNKNOWN",{"name":79,"class":77},"the Fundación Científica de la Asociación Española Contra el Cáncer",{"name":81,"class":6},"Associazione Italiana per la Ricerca sul Cancro",{"name":83,"class":77},"Freeman Hospital, UK",{"name":85,"class":77},"Liverpool Hospital",{"name":87,"class":6},"The Clatterbridge Cancer Centre NHS Foundation Trust","100626230","precision-medicine-approaches-for-neoadjuvant-therapy-in-high-risk-sarcoma-patients-100626230",false,"NCT07432932","Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients","PANTHR-S","Inclusion Criteria:\n\n* Written informed consent for the prospective cohort\n\n  * Histopathological diagnosis of high-risk soft tissue sarcoma and one of the following subtypes: DDLPS, LMS, SS, vascular sarcomas or MPNST. Other subtypes may be included with PI approval.\n  * High-risk sarcoma definition:\n\n    * Greater than 5cm or Grade 3\n    * Deep anatomic location\n  * Have disease amenable to biopsy\n\n    o Patients who are not amenable to repeat biopsy at baseline can be reviewed with the local site PI for consideration of inclusion to the study\n  * Resectable tumour\n  * Measurable disease by RECIST 1.1\n  * Aged ≥ 18 years\n  * WHO performance status 0-2\n  * For patients receiving NCT, medically fit enough, with adequate organ function, to undergo neoadjuvant chemotherapy\n  * Patients medically fit enough to undergo surgical resection\n  * Capable of giving written informed consent (for prospective cohort) and comply with the study schedule\n  * Patients may also participate in the STRASS 2 trial\n\nExclusion Criteria:\n\n-Prior invasive malignancy in last 5 years, low risk malignancies in the last 5 years may be reviewed by the PI.\n\n* Known additional malignancy that is progressing or requires active treatment\n* Metastatic disease not amenable to curative intent local therapy\n* Any active uncontrolled medical conditions","ALL","18 Years",{"count":98,"type":99},800,"ESTIMATED","OBSERVATIONAL","This is a cohort study aimed at developing a stratified medicine approach for personalised neoadjuvant chemotherapy (NCT) in high-risk soft tissue sarcoma (STS) patients with dedifferentiated liposarcoma (DDLPS), leiomyosarcoma (LMS), synovial sarcoma (SS), vascular sarcomas, malignant peripheral nerve sheath tumour (MPNST) or other subtypes. It comprises of both retrospective and prospective tissue collection from patients advancing directly to surgery (control group) and patients receiving NCT and surgery.",[103,104,105,106,107,108,109,110,111,112,113,114],"Sarcoma","Sarcoma, Leiomyo-, Adult","Sarcoma, Synovial, Adult","Soft Tissue Sarcoma (STS)","Soft Tissue Sarcoma Adult","Soft Tissue Sarcoma of the Trunk and Extremities","Soft Tissue Sarcoma of the Limb","Retroperitoneal Sarcoma","Liposarcoma, Dedifferentiated","Liposarcoma","Leiomyosarcoma (LMS)","Angiosarcoma",[116,117,118],"PANTHRS","PANTHRS-S","Sarcoma Accelerator","2026-02-18",{"date":121,"type":122},"2026-02-25","ACTUAL",{"date":124,"type":122},"2021-11-19",{"date":126,"type":99},"2028-06-30",{"name":5,"class":6},1]