[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100482842":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":16,"centralContacts":21,"locations":30,"responsibleParty":73,"collaborators":75,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":7,"maxAge":7,"enrollmentInfo":85,"targetDuration":7,"studyType":88,"phases":7,"briefSummary":89,"conditions":90,"keywords":7,"overallStatus":33,"whyStopped":7,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University of Manchester","OTHER",null,[9,13],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"PROCEDURE","Blood sample collection","Enrolled patients will undergo sequential blood collection beginning prior to conditioning, then on the day of transplant (day 0), followed by days 7, 14, 21, 28, 56 (2 months) and 90 (3 months) post-transplant.\n\nBone marrow aspirates taken within this period as part of routine care will also be collected, these are typically performed around day 100 and whenever there is suspicion of disease recurrence.\n\nThe study will also collect an additional blood sample at the onset of treatment for aGvHD for those who receive systemic corticosteroids (PO or IV steroid equivalent to ≥0.5mg\u002Fkg prednisolone).",{"type":10,"name":14,"description":15,"armGroupLabels":7,"otherNames":7},"Bone marrow aspirate","Bone marrow aspirates taken within this period as part of routine care will also be collected, these are typically performed around day 100 and whenever there is suspicion of disease recurrence.",[17],{"name":18,"affiliation":19,"role":20},"Mark Williams","CRUK Manchester Institute","PRINCIPAL_INVESTIGATOR",[22,26],{"name":18,"role":23,"phone":24,"phoneExt":7,"email":25},"CONTACT","+441613063240","mark.williams-4@cruk.manchester.ac.uk",{"name":27,"role":23,"phone":28,"phoneExt":7,"email":29},"Abbey Walker","0161 446 8201","abbey.walker@manchester.ac.uk",[31,50,61],{"facility":32,"status":33,"city":34,"state":7,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Manchester Royal Infirmary","RECRUITING","Manchester","m13 9wl","United Kingdom","UK",{"type":39,"coordinates":40},"Point",[41,42],-2.23743,53.48095,{"lat":42,"lon":41},[45,48],{"name":46,"role":23,"phone":7,"phoneExt":7,"email":47},"James Yates","james.yates@mft.nhs.uk",{"name":49,"role":20,"phone":7,"phoneExt":7,"email":7},"Fiona Dignan",{"facility":51,"status":33,"city":34,"state":7,"zip":52,"country":36,"countryCode":37,"cosmosGeoPoint":53,"geoPoint":55,"contacts":56},"Royal Manchester Children's Hospital","m139wl",{"type":39,"coordinates":54},[41,42],{"lat":42,"lon":41},[57,59],{"name":58,"role":23,"phone":7,"phoneExt":7,"email":47},"james Yates",{"name":60,"role":20,"phone":7,"phoneExt":7,"email":7},"Robert Wynn",{"facility":62,"status":33,"city":34,"state":7,"zip":63,"country":36,"countryCode":37,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"The Christie NHS Foundation Trust","M20 4BX",{"type":39,"coordinates":65},[41,42],{"lat":42,"lon":41},[68,71],{"name":69,"role":23,"phone":7,"phoneExt":7,"email":70},"Ellen Clarke","ellen.clarke4@nhs.net",{"name":72,"role":20,"phone":7,"phoneExt":7,"email":7},"Adrian Blloor",{"type":20,"investigatorFullName":18,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Principal Investigator",[76],{"name":62,"class":6},"100482842","precision-medicine-for-stem-cell-transplantation-100482842",false,"NCT05567289","Precision Medicine for Stem Cell Transplantation","PM-SCT","Inclusion Criteria:\n\n* Any recipient of allogeneic haematopoietic stem cell transplantation (HSCT)\n* Children\u002Finfants may participate, there is no age restriction\n* Patients participating in other clinical trials remain eligible\n\nExclusion Criteria:\n\n* Weight \\\u003C5kg\n* Recipients of autologous stem cell transplants","ALL",{"count":86,"type":87},300,"ESTIMATED","OBSERVATIONAL","A study of patients undergoing haematopoietic stem cell transplantation, a procedure in which patients are infused with stem cells from a donor, resulting in a new immune system that eliminates cancer or replaces diseased bone marrow. This study aims to develop new blood tests that predict the onset of acute graft-versus-host disease (aGvHD) and leukaemia relapse, two life-threatening complications that frequently limit the success of treatment. Predictive tests would allow doctors to individualise prophylaxis and intervene early to abort complications before they develop. The study will also create a large collection of clinically annotated blood samples from 300 transplant recipients to support future research and provide a resource to the transplant research community.",[91],"Haematopoietic Stem Cell Transplantation","2025-03-31",{"date":94,"type":95},"2025-04-03","ACTUAL",{"date":97,"type":95},"2023-06-06",{"date":99,"type":87},"2028-08",{"name":5,"class":6},3]