[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100421095":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":10,"locations":24,"responsibleParty":45,"collaborators":47,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":10,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Institute of Cancer Research, United Kingdom","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"AFFECTED",null,"1. Affected with PrCa \\\u003C60 years\n2. Affected with metastatic castration resistant PrCa (mCRPC) or aggressive PrCa (Gleason 4+4 or higher \\\u003C70 years\n3. Affected with PrCa and a family history defined as three or more cases any age (FDR or SDR)",[13],"Genetic: Prostate cancer risk gene panel",{"label":15,"type":10,"description":16,"interventionNames":17},"UNAFFECTED (Cohort now closed, recruitment complete)","\\- Aged \\>30 and with a family history defined as::\n\n1. FDR diagnosed \\\u003C 70\n2. 2 or more cases in First or Second Degree Relatives (FDR\u002FSDR) with one case diagnosed \\\u003C 70 years\n3. 3 or more cases at any age (on same side of family)",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"GENETIC","Prostate cancer risk gene panel","A list of genes created by study experts, thought to increase the risk of prostate cancer from from review previous research, this list is regularly reviewed for accuracy",[9,15],[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Royal Marsden Hosital,","RECRUITING","Sutton","England","SM2 5PT","United Kingdom","UK",{"type":34,"coordinates":35},"Point",[36,37],-0.2,51.35,{"lat":37,"lon":36},[40],{"name":41,"role":42,"phone":43,"phoneExt":10,"email":44},"Ros Eeles","CONTACT","0208 7224483","prostate.research@rmh.nhs.uk",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[48],{"name":49,"class":6},"Royal Marsden NHS Foundation Trust","100421095","precision-medicine-in-the-prostate-cancer-care-pathway-100421095",false,"NCT04763317","Precision Medicine in the Prostate Cancer Care Pathway","Precision Medicine in the Prostate Cancer Care Pathway: an Evaluation of Integrating Germline Genetic Testing Into the Management of Men at Risk of \u002F Living With Prostate Cancer","PMPRC","Inclusion Criteria:\n\nAffected cohort:\n\n1. Affected with PrCa \\\u003C 60 years or\n2. Affected with metastatic castration resistant PrCa (mCRPC) at any age or Aggressive PrCa Gleason 4+4 or higher \\\u003C70 years\n3. Affected with family history defined as three or more cases any age (FDR or SDR)\n\nUnaffected cohort: (This cohort is no longer recruiting, it has completed recruitment)\n\nAged \\>30 and with a family history defined as:\n\n1. FDR diagnosed \\\u003C 70\n2. 2 or more cases in First or Second Degree Relatives (FDR\u002FSDR) with one case diagnosed \\\u003C 70 years\n3. 3 or more cases at any age (on same side of family)\n\nExclusion Criteria:\n\n* • WHO performance status 4","MALE","30 Years","70 Years",{"count":62,"type":63},3000,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the use of a prostate cancer specific predisposition genetic panel test in men with \u002F at high risk of prostate cancer. The genetic test will analyse men's DNA samples for the presence of mutations in rare genes as well as common genetic variation to provide men with information about their risk of prostate cancer. This study will evaluate the clinical impact of the test on risk assessment and clinical management in terms of screening and treatment.",[67,68],"Prostate Cancer","Genetic Predisposition","2025-12-08",{"date":71,"type":72},"2025-12-16","ACTUAL",{"date":74,"type":72},"2019-02-14",{"date":76,"type":63},"2034-12",{"name":5,"class":6},1]