[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624345":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":18,"locations":24,"responsibleParty":35,"collaborators":10,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":39,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":10,"studyType":50,"phases":10,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":57,"whyStopped":10,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},{"fullName":5,"class":6},"University of Manchester","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Observational Cohort of oHCM Patients on Mavacamten",null,"This is a single, prospective, observational cohort of adult patients with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). Participants are either currently receiving or newly initiating mavacamten as part of their standard clinical care. All treatment decisions, including drug initiation, dosing, and titration, are made by the participant's treating physician and are not influenced by the study protocol. This cohort serves as the population from which clinical, pharmacological, and genomic data will be collected for analysis.",[13],"Other: Observational study, no new intervention offered",[15],{"type":6,"name":16,"description":16,"armGroupLabels":17,"otherNames":10},"Observational study, no new intervention offered",[9],[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Wei Jun How","CONTACT","+441619987070","weijun.how@manchester.ac.uk",[25],{"facility":26,"status":10,"city":27,"state":10,"zip":10,"country":28,"countryCode":29,"cosmosGeoPoint":10,"geoPoint":10,"contacts":30},"Manchester Centre for Genomic Medicine (MCGM)","Multiple Locations","United Kingdom","UK",[31,32],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},{"name":33,"role":34,"phone":10,"phoneExt":10,"email":10},"William Newman","PRINCIPAL_INVESTIGATOR",{"type":34,"investigatorFullName":20,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Cardiologist","100624345","precision-pharmacogenetics-and-genotype-class-based-prediction-of-mavacamten-response-in-obstructive-hypertrophic-cardiomyopathy-100624345",false,"NCT07408427","Precision Pharmacogenetics and Genotype Class Based Prediction of Mavacamten Response in Obstructive Hypertrophic Cardiomyopathy","PRO-Gene Mava","Inclusion Criteria:\n\n* Participants above the age of 18 years, with a confirmed diagnosis of oHCM, not solely explained by abnormal loading conditions (e.g. significant hypertension, valvular disease).\n\nExclusion Criteria:\n\n* HCM phenocopies (e.g., amyloid, Fabry's disease)\n* Prior septal reduction therapy (within 6 months)\n* Contraindications to mavacamten (e.g., baseline LVEF \\\u003C 55%, pregnancy, uncontrolled heart failure)","ALL","18 Years","99 Years",{"count":48,"type":49},140,"ESTIMATED","OBSERVATIONAL","This research study, aims to understand why a specific heart medication called mavacamten works better for some people with hypertrophic cardiomyopathy (HCM) than for others. We believe the answer might be in our genes.\n\nThe study focuses on two key areas:\n\n1. The specific gene causing HCM:The study will investigate whether the type of gene causing the condition in a person influences how well mavacamten works for them.\n2. Each individual carry a certain gene that helps metabolise and process medication (otherwise known as pharmacogenetics). Our research will closely examine a gene called CYP2C19 to see if a person's natural processing speed (slow, normal, or fast) affects the medicine's performance. The study will also look for rare genetic variations that standard tests might miss.",[53],"Hypertrophic Cardiomyopathy (HCM)",[55,56],"hypertrophic cardiomyopathy","pharmacogenetics","NOT_YET_RECRUITING","2026-02-06",{"date":60,"type":61},"2026-02-13","ACTUAL",{"date":63,"type":49},"2026-06",{"date":65,"type":49},"2029-12",{"name":5,"class":6},1]