[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100406890":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":22,"locations":30,"responsibleParty":50,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":72,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"University Hospital, Bonn","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Surgery",null,"Patients with and without liver cirrhosis undergoing surgery.",[13],"Other: No Intervention",[15],{"type":6,"name":16,"description":16,"armGroupLabels":17,"otherNames":10},"No Intervention",[9],[19],{"name":20,"affiliation":5,"role":21},"Michael Praktiknjo, MD","PRINCIPAL_INVESTIGATOR",[23,27],{"name":20,"role":24,"phone":25,"phoneExt":10,"email":26},"CONTACT","+4922828716375","michael.praktiknjo@ukbonn.de",{"name":28,"role":24,"phone":10,"phoneExt":10,"email":29},"Johannes Chang, MD","johannes.chang@ukbonn.de",[31],{"facility":32,"status":33,"city":34,"state":10,"zip":10,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"University Hospital Bonn","RECRUITING","Bonn","Germany","DE",{"type":38,"coordinates":39},"Point",[40,41],7.09549,50.73438,{"lat":41,"lon":40},[44,46,47],{"name":20,"role":24,"phone":45,"phoneExt":10,"email":26},"+49228 28715770",{"name":28,"role":24,"phone":45,"phoneExt":10,"email":29},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},"Nina Böhling, MD","SUB_INVESTIGATOR",{"type":21,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Michael Praktiknjo","PI","100406890","predicting-acute-on-chronic-liver-failure-after-surgical-intervention-in-chronic-liver-disease-100406890",false,"NCT04578301","Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease","PERSEVERE","Inclusion Criteria:\n\n* Male or female adult (≥18 years) patient\n* With or without liver cirrhosis (diagnosed either histologically or by a combination of clinical, laboratory and radiological signs)\n* Or Non-cirrhotic portal hypertension\n* Non-pregnant, non-lactating females\n* Ability to understand the patient information and to personally sign and date the informed consent to participate in the study\n* The patient is co-operative and available for the entire study\n* Provided written informed consent\n* Indication for surgical intervention\n\nExclusion Criteria:\n\n* Pregnant or lactating females\n* Patients undergoing surgery as form of palliative cancer therapy\n* Presence or history of severe extra-hepatic diseases\n* HIV-positive patients\n* Previous liver or other transplantation\n* Patients with acute or subacute liver failure without underlying cirrhosis\n* Patients who decline to participate\n* Physician´s denial (e.g. the investigator considers that the patient will not follow the protocol scheduled)","ALL","18 Years",{"count":63,"type":64},200,"ESTIMATED","OBSERVATIONAL","Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in cirrhotic patients. As well as identifying molecular mechanisms of post-interventional ACLF and thus preparing the ground for development of new therapeutic approaches.",[68,69,9,70,71],"Liver Cirrhosis","Portal Hypertension","Acute-On-Chronic Liver Failure","Non-Cirrhotic Portal Hypertension",[73,70,68,69,9,71],"ACLF","2022-05-17",{"date":76,"type":77},"2022-05-18","ACTUAL",{"date":79,"type":77},"2020-09-22",{"date":81,"type":64},"2026-12-31",{"name":5,"class":6},1]