[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627744":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":29,"locations":35,"responsibleParty":51,"collaborators":20,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":20,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":20,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":78,"overallStatus":37,"whyStopped":20,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University of Baghdad","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Vital Pulp Treatment (VPT)","EXPERIMENTAL","Participants with symptomatic teeth and carious pulp exposure will receive vital pulp treatment after caries removal. The specific procedure will be determined intraoperatively based on clinical criteria. Pulpal blood samples will be collected for metabolic biomarker analysis, followed by placement of a calcium silicate- based material and definitive restoration. Clinical and radiographic outcomes will be assessed over 12 months.",[13],"Procedure: vital pulp treatment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","vital pulp treatment","Vital pulp treatment (VPT) is defined by the European Society of Endodontology as a group of biologically based procedures aimed at preserving the health and function of the dental pulp that has been exposed or is at risk of exposure. These procedures involve removal of infected or inflamed tissue where necessary, protection of the remaining vital pulp with a biocompatible material, and placement of a definitive restoration to achieve a hermetic seal and support healing.",[9],null,[22,26],{"name":23,"affiliation":24,"role":25},"Anas F Mahdee, professor","College of dentistry\\ University of Baghdad","STUDY_CHAIR",{"name":27,"affiliation":24,"role":28},"Abeer G Abdulkhaliq","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":20,"email":34},"Abeer G Abdulkhaliq, master degree","CONTACT","964+7755564526","abeer.ghalib@codental.uobaghdad.edu.iq",[36],{"facility":24,"status":37,"city":38,"state":20,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Baghdad","964","Iraq","IQ",{"type":43,"coordinates":44},"Point",[45,46],44.40088,33.34058,{"lat":46,"lon":45},[49],{"name":50,"role":32,"phone":33,"phoneExt":20,"email":34},"Abeer G Abdulkhaliq, master",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"SPONSOR_INVESTIGATOR","Abeer Ghalib Abdul-khaliq","Dr.","100627744","predicting-vital-pulp-treatment-outcomes-in-symptomatic-pulpits-using-metabolic-biomarker-100627744",false,"NCT07452614","Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker","Efficacy of Metabolic Biomarkers in Predicting Twelve-Month Outcomes of Vital Pulp Treatment in Symptomatic Teeth With Carious Pulp Exposure: A Controlled Clinical Trial","Inclusion Criteria:\n\n1. Age range of 16-50 years.\n2. Pulp exposure during treatment of deep caries.\n3. Absence of periodontitis or systemic disease.\n4. Only one or two proximal surfaces lost with remaining walls \\> 2 mm; and\n5. Good compliance and signed informed consent forms.\n\nExclusion Criteria:\n\n1. Patients who meet any of the following criteria will be excluded:\n2. Teeth with unrestorable large defects or the need for RCT for aesthetic reasons;\n3. Teeth with a negative response to cold testing\n4. Current pregnancy or breastfeeding;\n5. Poor compliance or inability to complete the trial.\n6. The use of medications, including antibiotics, bisphosphonates, or statins, within 3 weeks before the study.\n7. Inadequate blood sample collection after pulpal exposure.",true,"ALL","16 Years","50 Years",{"count":67,"type":68},60,"ESTIMATED","INTERVENTIONAL",[71],"NA","This prospective controlled clinical trial investigates whether metabolic biomarkers measured in pulpal blood at the time of carious pulp exposure can predict the 12-month outcomes of vital pulp treatment in symptomatic permanent teeth. Eligible patients aged 16-50 years presenting with deep carious pulp exposure will undergo vital pulp therapy (partial pulpotomy or full pulpotomy). Pulpal blood samples will be collected at the time of exposure and analyzed using High-Performance Liquid Chromatography (HPLC). Treatment outcomes will be assessed clinically and radiographically at 12 months. The study aims to identify objective, measurable biomarkers that can improve pulpal diagnosis and guide clinical decision-making in vital pulp therapy.",[74,75,76,77],"Pulp Disease, Dental","Pulpitis","Reversible Pulpitis","Irreversible Pulpitis (Toothache)",[79,80,75,81],"Vital pulp treatment","Metabolic biomarker","Carious pulp exposure","2026-03-26",{"date":84,"type":85},"2026-04-01","ACTUAL",{"date":87,"type":85},"2026-02-20",{"date":89,"type":68},"2028-10",{"name":53,"class":6},1]