[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618701":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":34,"responsibleParty":112,"collaborators":10,"id":115,"slug":116,"hasResults":117,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":10,"eligibilityCriteria":121,"healthyVolunteers":117,"sex":122,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":10,"studyType":128,"phases":10,"briefSummary":129,"conditions":130,"keywords":135,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":151},{"fullName":5,"class":6},"Beijing Tsinghua Chang Gung Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Training set",null,"Cases in this subset are used for model training, testing and internal validation",[13],"Procedure: Major Hepatobiliary Surgery",{"label":15,"type":10,"description":16,"interventionNames":17},"External validation set","This part is for external validation of predictive models.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"PROCEDURE","Major Hepatobiliary Surgery","Patients undergo standard major hepatobiliary surgery (e.g., hepatectomy). The specific surgical strategy, including the method of hepatic inflow occlusion (e.g., Pringle maneuver or SPVO), is determined by the attending surgeon based on routine clinical practice and patient condition, not by the study protocol.",[15,9],[25],{"name":26,"affiliation":27,"role":28},"Zhifeng Gao, MD","Beijing Tsinghua Changgeng Hospital","PRINCIPAL_INVESTIGATOR",[30],{"name":26,"role":31,"phone":32,"phoneExt":10,"email":33},"CONTACT","+86-15801249466","gzfa02461@btch.edu.cn",[35,49,59,73,86,99],{"facility":36,"status":37,"city":38,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine，Tsinghua University","RECRUITING","Beijing","China","CN",{"type":42,"coordinates":43},"Point",[44,45],116.39723,39.9075,{"lat":45,"lon":44},[48],{"name":26,"role":31,"phone":32,"phoneExt":10,"email":33},{"facility":50,"status":37,"city":38,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":51,"geoPoint":53,"contacts":54},"Peking University International Hospital",{"type":42,"coordinates":52},[44,45],{"lat":45,"lon":44},[55],{"name":56,"role":31,"phone":57,"phoneExt":10,"email":58},"Lin Ding, MD","+86-13269092835","13269092835@163.com",{"facility":60,"status":37,"city":61,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"The First Affiliated Hospital of Army Medical University","Chongqing",{"type":42,"coordinates":63},[64,65],106.55771,29.56026,{"lat":65,"lon":64},[68,72],{"name":69,"role":31,"phone":70,"phoneExt":10,"email":71},"Zhiyu Chen, MD","+86-13983881219","chenzhiyu_umn@163.com",{"name":26,"role":31,"phone":10,"phoneExt":10,"email":33},{"facility":74,"status":37,"city":75,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Qingdao West Coast New Area People's Hospital","Qingdao",{"type":42,"coordinates":77},[78,79],120.38042,36.06488,{"lat":79,"lon":78},[82],{"name":83,"role":31,"phone":84,"phoneExt":10,"email":85},"peng Zhang, MD","+86-16678658917","zhangpeng27309@126.com",{"facility":87,"status":37,"city":88,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"The First Affiliated Hospital of Shandong First Medical University","Shandong",{"type":42,"coordinates":90},[91,92],120.48412,40.28464,{"lat":92,"lon":91},[95],{"name":96,"role":31,"phone":97,"phoneExt":10,"email":98},"Ming Hou, MD","+86-13869183831","13869183831@126.com",{"facility":100,"status":37,"city":101,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Zhuhai People's Hospital","Zhuhai",{"type":42,"coordinates":103},[104,105],113.56778,22.27694,{"lat":105,"lon":104},[108],{"name":109,"role":31,"phone":110,"phoneExt":10,"email":111},"Wenpeng Li, MD","+86-13431577611","liwenpeng324324@163.com",{"type":28,"investigatorFullName":113,"investigatorTitle":114,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Zhifeng Gao","Associate Professor","100618701","prediction-model-for-mins-after-major-hepatobiliary-surgery-100618701",false,"NCT07335042","Prediction Model for MINS After Major Hepatobiliary Surgery","Development of an Interpretable Prediction Model for Myocardial Injury After Noncardiac Surgery in Patients Undergoing Major Hepatobiliary Surgery","Inclusion Criteria:\n\nAdults (18-85 yr, ASA physical status II-III) undergoing major hepatobiliary surgery were enrolled. Major surgery was defined as duration ≥ 3 h involving hepatectomy (≥ 3 segments) or biliary reconstruction necessitating ICU admission. Eligibility required paired perioperative high-sensitivity cardiac troponin T (hs-cTnT) data and comprehensive documentation of surgical covariates, including surgical approach (laparoscopic vs. open), resection nature (anatomic vs. non-anatomic), number of resected segments, tumor characteristics (size and location), and presence of cirrhosis.\n\nExclusion Criteria:\n\n(1) preoperative acute myocardial infarction, unstable angina, heart failure, or chronic kidney disease (estimated glomerular filtration rate \\\u003C 60 ml\u002F (min · 1.73 m2); (2) undocumented inflow occlusion strategy; or (3) non-imputable missing covariates.","ALL","18 Years","85 Years",{"count":126,"type":127},1800,"ESTIMATED","OBSERVATIONAL","This multi-center, prospective observational study aims to develop and validate an interpretable prediction model for Myocardial Injury After Noncardiac Surgery (MINS) in patients undergoing major hepatobiliary surgery. The study adopts a nested modeling strategy, starting with baseline risk factors (e.g., RCRI) and stepwise incorporating hepatic inflow occlusion strategies (specifically comparing SPVO vs. Pringle maneuver) and routine intraoperative biomarkers. The model's performance will be evaluated using AUC, Net Reclassification Improvement (NRI), and Decision Curve Analysis (DCA), followed by interpretability analysis using SHAP values and external validation in an independent cohort.",[131,132,133,134],"Myocardial Injury After Noncardiac Surgery (MINS)","Postoperative Complications","Liver Neoplasm","Hepatobiliary Diseases",[136,21,137,138,139,140,141],"MINS","Hepatectomy","Hepatic Inflow Occlusion","Pringle Maneuver","Prediction Model","High-sensitivity Cardiac Troponin","2026-06-12",{"date":144,"type":145},"2026-06-15","ACTUAL",{"date":147,"type":145},"2026-01-14",{"date":149,"type":127},"2027-06-30",{"name":5,"class":6},6]