[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558436":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":27,"locations":36,"responsibleParty":54,"collaborators":57,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":9,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":18,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":18,"overallStatus":39,"whyStopped":18,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Columbia University","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"CAMERA","Adult subjects with epilepsy will undergo noninvasive video Electroencephalography (EEG) and intracranial electrodes sampling the amygdala and hippocampus (unilateral or bilateral). A subset of subjects (n=10) will use the Context-Aware Multimodal Ecological Research and Assessment (CAMERA) platform for 2 weeks after discharge with a subset of modalities: physiologic wristband, smartphone phenotyping, ecological momentary assessment (EMA) surveys, and memory task. At unpredictable intervals, CAMERA will interrupt subjects with: (a) an audible alarm to elicit an acoustic startle response; (b) a self-reported anxiety state scale; and (c) a visuospatial memory task with threat interference. For example, participants will fill out a brief survey and play a video game several times each day and wear a wristband with sensors.",[12],"Other: CAMERA (Context-Aware Multimodal Ecological Research and Assessment)",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":18},"CAMERA (Context-Aware Multimodal Ecological Research and Assessment)","The CAMERA platform is a multimodal, hardware-software framework for measuring brain-behavior interactions in an unstructured environment and predict ecological states. CAMERA will use multimodal, passive sensor data to predict anxiety-memory state in patients undergoing inpatient monitoring with intracranial electrodes for clinical epilepsy. CAMERA consists of: Wristband sensors of autonomic physiologic signals, emphasizing heart rate metrics and electrodermal activity; Smartphone usage, emphasizing natural language processing of text input for linguistic features; Subject-tracking audiovisual array, emphasizing subject vocal activity; Intracranial neural recordings, emphasizing hippocampal theta power and high-frequency activity (\\~70-200 Hz).",[9],null,[20,24],{"name":21,"affiliation":22,"role":23},"Joshua Jacobs, PhD","University of Chicago","STUDY_DIRECTOR",{"name":25,"affiliation":5,"role":26},"Brett E Youngerman, MD","PRINCIPAL_INVESTIGATOR",[28,32],{"name":25,"role":29,"phone":30,"phoneExt":18,"email":31},"CONTACT","516-946-2145","bey2103@cumc.columbia.edu",{"name":33,"role":29,"phone":34,"phoneExt":18,"email":35},"Angela Velazquez","646-515-1909","agv2113@cumc.columbia.edu",[37],{"facility":38,"status":39,"city":40,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Columbia University Irving Medical Center","RECRUITING","New York","10032","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-74.00597,40.71427,{"lat":48,"lon":47},[51,53],{"name":25,"role":29,"phone":52,"phoneExt":18,"email":31},"646-317-2887",{"name":25,"role":26,"phone":18,"phoneExt":18,"email":18},{"type":26,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Brett Youngerman","Assistant Professor of Neurological Surgery",[58,61,63],{"name":59,"class":60},"National Institute of Mental Health (NIMH)","NIH",{"name":62,"class":6},"Rutgers University",{"name":64,"class":6},"University of Minnesota","100558436","prediction-of-anxiety-and-memory-state-100558436",false,"NCT06551090","Prediction of Anxiety and Memory State","Developing the Context-Aware Multimodal Ecological Research and Assessment (CAMERA) Platform for Continuous Measurement and Prediction of Anxiety and Memory State","Inclusion Criteria:\n\n* Patients must have known or suspected Temporal Lobe Epilepsy.\n* Native or proficient in speaking English or Spanish.\n* Stereoelectroencephalography (sEEG) cases: The implant plan must include hippocampal head, body, and tail electrodes either unilaterally or bilaterally.\n* 7th grade reading level (minimum level considered literate for adults)\n\nExclusion Criteria:\n\n* Hearing impaired (i.e., not corrected with a hearing aid)\n* Unable to read the newspaper at arm's length with corrective lenses.\n* Objective intellectual impairment (estimated IQ \\\u003C 70)\n* Any history of Electroconvulsive Therapy or psychosis (except postictal psychosis for patients)\n* Psychotic disorder (lifetime)\n* Current Anxiety disorder, Major Depressive Disorder, or Bipolar Disorder\n* Neurodegenerative diseases, presence of widespread brain lesions, language problems (other than naming difficulty)\n* Medical conditions that could potentially affect cognitive performance (e.g., human immunodeficiency virus (HIV) infection, cancer with metastatic potential).\n* Acute renal failure or end-stage renal disease","ALL","18 Years","55 Years",{"count":76,"type":77},40,"ESTIMATED","INTERVENTIONAL",[80],"NA","The purpose of this study is to look at how signals in the brain, body, and behavior relate to anxiety and memory function. This project seeks to develop the CAMERA (Context-Aware Multimodal Ecological Research and Assessment) platform, a state-of-the-art open multimodal hardware\u002Fsoftware system for measuring human brain-behavior relationships.\n\nThe R61 portion of the project is designed to develop the CAMERA platform, which will use multimodal, passive sensor data to predict anxiety-memory state in patients undergoing inpatient monitoring with intracranial electrodes for clinical epilepsy, as well as to build CAMERA's passive data framework and active data framework.",[83,84,85],"Anxiety","Memory","Epilepsy","2026-01-26",{"date":88,"type":89},"2026-01-28","ACTUAL",{"date":91,"type":89},"2024-07-23",{"date":93,"type":77},"2026-12-01",{"name":5,"class":6},1]