[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100542691":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":24,"centralContacts":29,"locations":37,"responsibleParty":58,"collaborators":60,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":7,"enrollmentInfo":73,"targetDuration":7,"studyType":76,"phases":7,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":40,"whyStopped":7,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Ciusss de L'Est de l'Île de Montréal","OTHER",null,[9,13,17,20],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Cognitive testing","Preoperative cognitive battery test",{"type":14,"name":15,"description":16,"armGroupLabels":7,"otherNames":7},"DEVICE","electroencephalogram","Preoperative 24 channel EEG",{"type":14,"name":18,"description":19,"armGroupLabels":7,"otherNames":7},"High density electroencephalogram","preoperative 128-channel electroencephalogram",{"type":21,"name":22,"description":23,"armGroupLabels":7,"otherNames":7},"PROCEDURE","General anesthesia","induction of general anesthesia using propofol 1%",[25],{"name":26,"affiliation":27,"role":28},"Louis Morisson, MD, MSc","CIUSSS de l'Est de l'Ile de Montréal","PRINCIPAL_INVESTIGATOR",[30,34],{"name":26,"role":31,"phone":32,"phoneExt":7,"email":33},"CONTACT","514-252-3400","louis.morisson@umontreal.ca",{"name":35,"role":31,"phone":32,"phoneExt":7,"email":36},"Nadia Godin, RN","nadia.godin.hmr@ssss.gouv.qc.ca",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Hopital Maisonneuve-Rosemont","RECRUITING","Montreal","Quebec","H1T 2M4","Canada","CA",{"type":47,"coordinates":48},"Point",[49,50],-73.58781,45.50884,{"lat":50,"lon":49},[53,56],{"name":35,"role":31,"phone":32,"phoneExt":54,"email":55},"3426","ngodin.hmr@ssss.gouv.qc.ca",{"name":57,"role":28,"phone":7,"phoneExt":7,"email":7},"Louis Morisson, M.D., M.Sc.",{"type":59,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[61],{"name":62,"class":6},"Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal","100542691","prediction-of-propofol-effect-site-concentration-associated-with-deep-anesthesia-100542691",false,"NCT06346158","Prediction of Propofol Effect-Site Concentration Associated With Deep Anesthesia","Prediction of Propofol Effect-Site Concentration Associated With Deep Anesthesia During Induction of General Anesthesia Based on Electroencephalographic Features: a Prospective Observational Study","PRESCOD-AI","Inclusion Criteria:\n\n* Scheduled for any kind of surgery under general anesthesia.\n* Adults\n\nExclusion Criteria:\n\n* Inability to communicate in French or English,\n* Known allergy or intolerance or other medical condition that precludes the use of prescribed general anesthesia protocol for this study,\n* Patients requiring rapid sequence induction,\n* Anticipated or known difficult intubation patient,\n* Anticipated or known difficult ventilation patient,\n* Body mass index ≥ 35 kg.m-2.","ALL","18 Years",{"count":74,"type":75},110,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to explore the variability of the concentration at the effect site (Ce) of propofol to reach deep anesthesia (DA) during induction of general anesthesia in adults.\n\nThe investigators hypothesized that there is a great variability in this Ce that could be precisely explained by\n\n* Electroencephalographic (EEG) features available prior to induction of anesthesia\n* Cognitive performance\n* Patients characteristics Participants will undergo preoperative cognitive testing and awake EEG. Then, induction of general anesthesia will be performed using continuous infusion of propofol. The Ce at which Deep anesthesia is observed will be recorded.",[79],"Anesthesia",[81,82,83,84,85,15],"general anesthesia","propofol","interindividual variability","prediction","cognitive performance","2026-01-15",{"date":88,"type":89},"2026-01-16","ACTUAL",{"date":91,"type":89},"2025-04-07",{"date":93,"type":75},"2027-01",{"name":5,"class":6},1]