[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581622":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":10,"centralContacts":22,"locations":28,"responsibleParty":47,"collaborators":49,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":69,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":10,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Istituto Clinico Humanitas","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Control",null,"healthy mothers",{"label":13,"type":10,"description":14,"interventionNames":15},"diseased","Infected mothers",[16],"Other: Infection during pregnancy",[18],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"Infection during pregnancy","any bacterial or viral infection acquired during pregnancy",[13],[23],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Antonella Pisano, Dr.","CONTACT","+39 02 82244501","contratti.ricerca@humanitas.it",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"AOUP","RECRUITING","Pisa","PI","56126","Italy","IT",{"type":38,"coordinates":39},"Point",[40,41],10.4036,43.70853,{"lat":41,"lon":40},[44],{"name":45,"role":25,"phone":46,"phoneExt":10,"email":10},"Tommaso Simoncini, MD","+39 050993523",{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[50,52],{"name":51,"class":6},"IRCCS Fondazione Stella Maris",{"name":53,"class":6},"Azienda Ospedaliero, Universitaria Pisana","100581622","predictive-biomarkers-of-altered-neurological-trajectories-consequent-to-prenatal-inflammatory-insults-100581622",false,"NCT06852703","Predictive BioMArkers of AlTERed NeurologicAL Trajectories Consequent to PrenataL InflammatorY Insults","Predictive BioMArkers of AlTERed NeurologicAL Trajectories Consequent to PrenataL","MATERNALLY","Inclusion Criteria:\n\nAge between 18 and 40 years. BMI between 18 kg\u002Fm2 and 25 kg\u002Fm2. Negative remote medical history for chronic conditions (rheumatological, immunological, endocrinological).\n\nNegative obstetric history for significant pathologies (pre-eclampsia, gestational diabetes, preterm birth).\n\nReassuring combined test\n\nExclusion Criteria:\n\n* Pre-gestational diabetes\n* Multiple pregnancy\n* Threatened preterm labor and\u002For premature rupture of membranes\n* Pre-eclampsia\n* Intrauterine growth restriction (IUGR)\n* Fetal macrosomia (biometrics \\>90th percentile)\n* Chromosomal syndromes, genetic conditions, or multiple fetal malformations or major fetal malformations\n* Withdrawal of informed consent\n* Smoking patients are not excluded from the study, nor are patients who develop gestational diabetes during pregnancy.",true,"FEMALE","18 Years","40 Years",{"count":67,"type":68},300,"ESTIMATED","3 Years","OBSERVATIONAL","Inflammation during pregnancy represents an important risk factor for the development of neuropsychiatric disorders in the offspring. Despite clear epidemiological data supporting this association, translational studies aimed at identifying early predictive biomarkers and possible interventional strategies for this pathological condition are still missing. The MATERNALLY proposal aims to assess in a large patient cohort a novel multiparametric approach for the identification of predictive postnatal behavioral and circulating biomarkers. In parallel, a controlled mouse model for maternal immune activation will be exploited to understand the basic molecular mechanism that links inflammation with aberrant neural circuit formation and to unveil possible therapeutic targets. The integration of the two approaches will allow identifying early predictive biomarkers and proof of principle interventional strategies for this condition of high practical relevance to the neonatologist community",[73,74,75],"Biomarkers","Neurodevelopmental Disorders","Inflammation, Brain","2025-02-24",{"date":78,"type":79},"2025-02-28","ACTUAL",{"date":81,"type":79},"2021-09-01",{"date":83,"type":68},"2025-08-31",{"name":5,"class":6},1]