[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100551072":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":43,"collaborators":45,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":19,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":29,"whyStopped":19,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University Hospital, Lille","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"All patients will part of the same follow-up study.","EXPERIMENTAL","All patients will part of the same follow-up study. No treatment will be compared. Patients will be treated as recommended.",[13],"Other: Optic nerve MRI sequence",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Optic nerve MRI sequence","Systematic optic nerve MRI sequence during the CIS diagnosis work-up. This sequence is not done systematically and not recommended for now (except in case of acute ON). The interventional nature of the study remains minimal",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Juliette Bochu","CONTACT","0320444145","juliette.bochu@chu-lille.fr",[27],{"facility":28,"status":29,"city":30,"state":19,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Hôpital Roger Salengro","RECRUITING","Lille","59037","France","FR",{"type":35,"coordinates":36},"Point",[37,38],3.05512,50.63391,{"lat":38,"lon":37},[41],{"name":42,"role":23,"phone":19,"phoneExt":19,"email":19},"Olivier Outteryck",{"type":44,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR",[46,48,50,52,54,56],{"name":47,"class":6},"Région Nord-Pas de Calais, France",{"name":49,"class":6},"Amiens University Hospital",{"name":51,"class":6},"Boulogne sur Mer Hospital Center",{"name":53,"class":6},"Centre Hospitalier VALENCIENNES",{"name":55,"class":6},"Centre Hospitalier de Roubaix",{"name":57,"class":6},"Centre Hospitalier de Lens","100551072","predictive-value-of-the-optic-nerve-involvement-in-clinically-isolated-syndrome-100551072",false,"NCT06455332","Predictive Value of the Optic Nerve Involvement in Clinically Isolated Syndrome","Evaluation of the Predictive Value of the Optic Nerve Involvement at the Stage of Clinically Isolated Syndrome, for the Diagnosis of Clinically Definite Multiple Sclerosis and the Delay of Second Relapses' Occurrence","HdeFIMS","Inclusion Criteria:\n\n* Patients between 18 and 55 years old\n* Occurrence of CIS ≤ 6 months\n* With two T2 hypersignals on brain\u002Fspinal cord MRI suggestive of MS or with oligoclonal bands\n* Giving their written informed consent\n\nExclusion Criteria:\n\n* Pathological conditions that may skew the optic nerve MRI and\u002For retinal OCT (diabetes mellitus, glaucoma, retinopathy, ametropia \\>6 dioptria)\n* Past history of MS relapses\n* Extensive myelitis (\\>3 vertebral bodies)\n* Bilateral optic neuritis without T2 lesions suggestive of MS\n* Contra-indication to MRI, gadolinium injection\n* Pregnancy, breast-feeding\n* Patients unable to consent","ALL","18 Years","55 Years",{"count":70,"type":71},200,"ESTIMATED","INTERVENTIONAL",[74],"NA","Optic neuritis (ON) represents around 30% of clinical presentation of clinically isolated syndrome (CIS). Asymptomatic optic nerve involvement is very frequent in all stage of multiple sclerosis (MS) disease including the CIS. However, optic nerve is still not part of MS diagnosis criteria. The main objective of our regional and multicenter study is to evaluate the prognostic value of optic nerve involvement at the earliest clinical stage of MS (=CIS) for the diagnosis of clinically definite MS (2nd clinical relapse) and the delay until the 2nd relapse.",[77,78],"Clinically Isolated Syndrome","Multiple Sclerosis",[80,81,82,83,84,85],"Clinically isolated syndrome","Multiple sclerosis","MRI","Optical coherence tomography","Optic nerve","Diagnostic criteria","2025-08-19",{"date":88,"type":89},"2025-08-24","ACTUAL",{"date":91,"type":89},"2025-07-17",{"date":93,"type":71},"2028-07-01",{"name":5,"class":6},1]