[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559656":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":35,"centralContacts":36,"locations":47,"responsibleParty":74,"collaborators":77,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":82,"sex":88,"minAge":89,"maxAge":35,"enrollmentInfo":90,"targetDuration":35,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":35,"overallStatus":50,"whyStopped":35,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Palo Alto Veterans Institute for Research","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Prehabilitation","EXPERIMENTAL","Subjects randomized to the prehabilitation group will undergo 6 weeks of individualized exercise therapy, including a 1-week ramp-up period (3 sessions) conducted at the VAPAHCS rehabilitation facility. Subjects will then exercise primarily at home, with an in-clinic exercise session repeated weekly for the duration of their participation. These sessions will be individualized based on tolerance and in accordance with standardized guidelines, but will generally consist of 45-60 min of supervised exercise that combines aerobic and resistance training, including warm-up and cool-down. Throughout the study, subjects will be asked to perform 30 minutes of daily unsupervised aerobic exercise of their choice, with an emphasis on improving walking performance at home. Guidelines for patient monitoring, safety, and prescription outlined by the American Heart Association, American College Sports Medicine, and American Association of Cardiovascular and Pulmonary Rehabilitation will be followed.",[13,14],"Other: Exercise Intervention","Other: VAPAHCS Rehabilitation Core Components",{"label":16,"type":17,"description":18,"interventionNames":19},"Rehabilitation","ACTIVE_COMPARATOR","Subjects randomized to the rehabilitation group will initiate exercise sessions approximately 2-weeks following endovascular intervention as outlined in guidelines for PAD. Patient stability and wound patency will be paramount considerations prior to a patient beginning the rehabilitation program. Similar to prehabilitation, subjects will undergo a 1-week, 3 session familiarization period conducted at the VAPAHCS rehabilitation facility, then return once weekly for in-clinic supervised sessions. The weekly in-person visits will be conducted at the rehabilitation center to monitor and encourage compliance, review activity questionnaires, download accelerometry data, and address any clinical concerns. Similar to participants in the prehabilitation group, the 6-week rehabilitation period will be individualized and follow standardized guidelines designed for rehabilitation in patients with PAD.",[13,14],{"label":21,"type":10,"description":22,"interventionNames":23},"Prehabiliation and Rehabilitation","Subjects randomized to the prehabilitation and rehabilitation group will undergo both the 6 weeks of prehabilitation pre-operative and 6 weeks of rehabilitation post-operative as described in their respective arm descriptions.",[13,14],[25,31],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"Exercise Intervention","Aerobic and resistance exercise will be components of the prehabiliation and rehabilitation programs. Given the presence of PAD, a particular emphasis will be placed on volume of walking and improving walking performance.",[21,9,16],[30],"Exercise Therapy",{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"VAPAHCS Rehabilitation Core Components","The prehabilitation and rehabilitation programs include all Core Components of rehabilitation as outlined in guidelines. The current clinical VAPAHCS program includes smoking cessation, nutrition, risk factor management and psychosocial counseling referrals as appropriate, and these services will be available for the current proposal.",[21,9,16],null,[37,43],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},"Jonathan N Myers, PhD","CONTACT","650-493-5000","64661","drj993@aol.com",{"name":44,"role":39,"phone":45,"phoneExt":35,"email":46},"Charles G Gronau, DCEP","618-746-69565","gronauc92@gmail.com",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"VA Palo Alto Health Care System","RECRUITING","Palo Alto","California","94304","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-122.14302,37.44188,{"lat":60,"lon":59},[63,64,66,68,70,72],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},{"name":44,"role":39,"phone":65,"phoneExt":35,"email":46},"618-746-6956",{"name":38,"role":67,"phone":35,"phoneExt":35,"email":35},"PRINCIPAL_INVESTIGATOR",{"name":44,"role":69,"phone":35,"phoneExt":35,"email":35},"SUB_INVESTIGATOR",{"name":71,"role":69,"phone":35,"phoneExt":35,"email":35},"Khin N Chan, MD",{"name":73,"role":69,"phone":35,"phoneExt":35,"email":35},"Pallavi Gautam, MPT",{"type":67,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"Jonathan Myers","Principal Investigator",[78],{"name":79,"class":6},"Patient-Centered Outcomes Research Institute","100559656","prehabilitation-and-rehabilitation-in-pad-100559656",false,"NCT06566976","Prehabilitation and Rehabilitation in PAD","Prehabilitation and Rehabilitation in PAD: A Randomized Exercise Intervention Trial (PREPARE-IT)","PREPARE-IT","Inclusion Criteria:\n\n* Male or Female adult diagnosed with peripheral artery disease (PAD)\n* Experiencing leg pain while walking\n* Scheduled to have a stent for PAD\n* Able to perform exercise safely\n* Postmenopausal and not of child bearing capacity\n\nExclusion Criteria:\n\n* Medically unstable patients\n* Recent MI within 3 months\n* Malignancy\n* Uncontrolled diabetes mellitus (HBA1C ≥8 mmol\u002Fl)\n* Alcoholism or other recreational drug use","ALL","18 Years",{"count":91,"type":92},300,"ESTIMATED","INTERVENTIONAL",[95],"NA","To determine the effectiveness of pre and post-operative exercise therapy in patients undergoing peripheral artery stenting for peripheral arterial disease.",[98],"Peripheral Arterial Disease","2024-08-19",{"date":101,"type":102},"2024-08-22","ACTUAL",{"date":104,"type":102},"2024-03-07",{"date":106,"type":92},"2027-07-25",{"name":5,"class":6},1]