[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612587":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":41,"responsibleParty":66,"collaborators":68,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":75,"sex":81,"minAge":82,"maxAge":18,"enrollmentInfo":83,"targetDuration":18,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":101,"whyStopped":18,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Hospital del Salvador","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Prehabilitation Program","EXPERIMENTAL","Participants in this arm will receive a multimodal prehabilitation program that includes supervised aerobic and resistance exercise, balance and flexibility training, respiratory exercises, education on healthy lifestyle behaviors, and occupational therapy. The intervention is delivered in a hybrid format (in-person and remote), 2-3 sessions per week for 15-18 sessions in total.",[13],"Other: Multimodal Prehabilitation",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual Care","NO_INTERVENTION","Participants in this arm will receive standard medical care as determined by their clinical team. No structured prehabilitation or additional exercise-based intervention will be provided.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Multimodal Prehabilitation","In-Person Sessions:\n\nSupervised by a cancer-specialized physiotherapist. Includes:\n\n* Aerobic exercise: 20-25 min. at moderate intensity (BORG 4-6 or 60-80% HRmax).\n* Resistance training: 20-25 min. at 10-12 RM, using dumbbells or resistance bands.\n* Flexibility or balance training: 5 minutes.\n* Warm-up and cool-down: 5 minutes each.\n\nSessions last 1-1.5 hours, 2-3 times\u002Fweek, 15-18 sessions Education on healthy habits, smoking and alcohol cessation, sleep hygiene, and physical activity.\n\nDaily home-exercise logs and telephone supervision will support adherence.\n\nRemote Sessions:\n\n(Video call\u002FZoom, 45-60 min): Mixed exercises, breathing techniques, and incentive spirometry.\n\nOccupational Therapy Intervention\n\n* cognitive training (memory, attention, executive function),\n* upper limb functional training (fine\u002Fgross motor skills, bilateral coordination, prehension)\n* ADL\u002FIADL training\n* energy-conservation techniques and joint-protection strategies. 6-8 sessions, 30-45 min.",[9],[25,26],"Exercise Intervention","Occupational Therapy Intervention",[28],{"name":29,"affiliation":5,"role":30},"Luz Alejandra Lorca, Master","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},"Ivana Gonzales Valdivia, PT","CONTACT","+56942732848","igonzalezv@hsalvador.cl",{"name":38,"role":34,"phone":39,"phoneExt":18,"email":40},"Ivana Leao Ribeiro, PhD","+569 65990637","ivanaleao@gmail.com",[42,54],{"facility":5,"status":18,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":18},"Santiago","Providencia","8320000","Chile","CL",{"type":49,"coordinates":50},"Point",[51,52],-70.64827,-33.45694,{"lat":52,"lon":51},{"facility":5,"status":18,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":55,"geoPoint":57,"contacts":58},{"type":49,"coordinates":56},[51,52],{"lat":52,"lon":51},[59,63,65],{"name":60,"role":34,"phone":61,"phoneExt":18,"email":62},"Luz Alejandra Lorca, MSc","+569 82092139","llorca@hsalvador.cl",{"name":60,"role":34,"phone":61,"phoneExt":18,"email":64},"alejandralorcap@gmail.com",{"name":60,"role":30,"phone":18,"phoneExt":18,"email":18},{"type":67,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[69,71],{"name":70,"class":6},"Universidad Católica del Maule",{"name":72,"class":6},"University of Chile","100612587","prehabilitation-to-improve-frailty-function-and-quality-of-life-in-candidates-for-hematopoietic-stem-cell-transplantation-100612587",false,"NCT07255521","Prehabilitation to Improve Frailty, Function, and Quality of Life in Candidates for Hematopoietic Stem Cell Transplantation","Effects of a Prehabilitation Program on Frailty, Function, Quality of Life, and Post-Transplant Outcomes in Candidates for Hematopoietic Stem Cell Transplantation: A Randomized Clinical Trial","PREHAB-HSCT","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Diagnosis of hematologic malignancy requiring HSCT (autologous or allogeneic).\n* Minimum of ≥4 weeks available before the scheduled transplant.\n* \"Pre-frail\" or \"frail\" according to the HCT Frailty Scale.\n* ECOG ≤2 or Karnofsky ≥60.\n* Internet access (videocalls, Zoom platform, or a facilitator) for remote sessions.\n\nExclusion Criteria:\n\n* Cognitive impairment preventing questionnaire completion.\n* Musculoskeletal comorbidities preventing participation in supervised exercise-based prehabilitation.\n* Prior chemotherapy or radiotherapy not related to the hematologic malignancy.\n* Medical conditions limiting participation (e.g., unstable angina, arrhythmia, hypertension or heart failure, acute systemic infection with fever, acute myocarditis, or pericarditis).","ALL","18 Years",{"count":84,"type":85},68,"ESTIMATED","INTERVENTIONAL",[88],"NA","Candidates for hematopoietic stem cell transplantation (HSCT) frequently experience declines in strength, physical function, and quality of life before the procedure. Many also present fatigue, limitations in daily activities, and an increased risk of complications during and after hospitalization. Optimizing physical condition before transplantation may improve post-procedure recovery.\n\nThis study will evaluate whether a prehabilitation program improves physical function, frailty, and quality of life in adults preparing for HSCT. The intervention consists of supervised exercise, education, and activities designed to enhance endurance and functional capacity. Although prehabilitation has shown benefits in other oncologic populations, it has been minimally studied in HSCT candidates, and no structured programs have been evaluated in Chile.\n\nA total of 68 adults will be randomly assigned to a prehabilitation group or a usual-care control group. The prehabilitation group will receive a personalized program including aerobic and resistance exercise, stretching, balance training, respiratory exercises, and education on healthy behaviors, delivered through a hybrid model of in-person and remote sessions. Occupational therapy will also be provided to support functional and cognitive abilities. The control group will continue with standard medical care.\n\nBaseline and post-intervention assessments will include measures of strength, frailty, fatigue, balance, cognitive function, daily activities, and quality of life. Post-transplant outcomes such as hospital length of stay, complications, and readmissions within three months will also be recorded. Feasibility, adherence, satisfaction, and adverse events will be evaluated.\n\nFindings from this trial may inform the development of structured prehabilitation programs for HSCT candidates and support the implementation of evidence-based supportive care strategies in hematologic oncology.",[91],"Hematopoietic Stem Cell Transplantation (HSCT)",[93,94,95,96,97,98,99,100],"Prehabilitation","Hematologic Malignancies","Frailty","Cancer-Related Frailty","Functional capacity","Physical Function","Quality of life","Post-Transplant Outcomes","NOT_YET_RECRUITING","2025-12-07",{"date":104,"type":105},"2025-12-15","ACTUAL",{"date":107,"type":85},"2025-12-26",{"date":109,"type":85},"2026-06-30",{"name":5,"class":6},2]