[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573294":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":91,"collaborators":94,"id":102,"slug":103,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":104,"sex":110,"minAge":111,"maxAge":18,"enrollmentInfo":112,"targetDuration":18,"studyType":115,"phases":116,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":52,"whyStopped":18,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":141},{"fullName":5,"class":6},"Università Vita-Salute San Raffaele","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Prehabilitation","EXPERIMENTAL","Prehabilitation arm groups will receive preoperative intervention which includes exercise training, nutritional therapy and anxiety reducing techniques, aimed at preventing or attenuating surgery-driven functional decline.",[13],"Behavioral: Multimodal prehabilitation program",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Standard care treatment: application of ERAS pathways (Enhanced Recovery After Surgery)",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Multimodal prehabilitation program","A tailored intervention will be prescribed if specific physical, nutritional or psychological impairments will be identified during the assessment phase. Based on the data obtained during the multimodal assessment, different domains and levels of care will be prescribed, focusing on exercise training, and\u002For nutrition optimization, and\u002For distress-coping techniques. Different combinations of these three domains will be utilized to maximize their synergistic anabolic effect.\n\nThe duration of the program will be set at 4 weeks.",[9],[26],{"name":27,"affiliation":28,"role":29},"Fabio Guarracino, Doctor","Azienda Ospedaliero, Universitaria Pisana","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":18,"email":35},"Fabio Guarracino, Dr","CONTACT","+393281652528","f.guarracino@ao-pisa.toscana.it",[37,50,65,79],{"facility":38,"status":39,"city":40,"state":18,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":18},"Azienda Ospedaliero Universitaria Policlinico San Marco di Catania","ACTIVE_NOT_RECRUITING","Catania","95100","Italy","IT",{"type":45,"coordinates":46},"Point",[47,48],15.07041,37.49223,{"lat":48,"lon":47},{"facility":51,"status":52,"city":53,"state":18,"zip":54,"country":42,"countryCode":43,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Università di Foggia","RECRUITING","Foggia","71100",{"type":45,"coordinates":56},[57,58],15.55188,41.45845,{"lat":58,"lon":57},[61],{"name":62,"role":33,"phone":63,"phoneExt":18,"email":64},"Gilda Cinnella, Medical Doctor","+393204394598","gilda.cinnella@unifg.it",{"facility":66,"status":52,"city":67,"state":18,"zip":68,"country":42,"countryCode":43,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"IRCCS Ospedale San Raffaele","Milan","20132",{"type":45,"coordinates":70},[71,72],12.59836,42.78235,{"lat":72,"lon":71},[75],{"name":76,"role":33,"phone":77,"phoneExt":18,"email":78},"Giovanni G Landoni, Full Professor","+393472520801","landoni.giovanni@hsr.it",{"facility":80,"status":52,"city":81,"state":18,"zip":82,"country":42,"countryCode":43,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Azienda Ospedaliero Universitaria Pisana","Pisa","56126",{"type":45,"coordinates":84},[85,86],10.4036,43.70853,{"lat":86,"lon":85},[89],{"name":90,"role":33,"phone":34,"phoneExt":18,"email":35},"Fabio Guarracino, Medical Doctor",{"type":29,"investigatorFullName":92,"investigatorTitle":93,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Giovanni Landoni","Full professor",[95,98,100],{"name":96,"class":97},"Dott. Fabio Guarracino","UNKNOWN",{"name":99,"class":97},"Prof. Gilda Cinnella",{"name":101,"class":97},"Dott. Filippo Sanfilippo","100573294","prehabilitation-to-improve-heart-rate-variability-prime-100573294",false,"NCT06744413","Prehabilitation to Improve Heart Rate Variability (PRIME)","Prehabilitation to Improve Heart Rate Variability In Surgical Cancer Patients: a randoMized controllEd Trial","PRIME","Inclusion Criteria:\n\n1. Scheduled to undergo elective major abdominal or thoracic cancer surgery;\n2. Scheduled to undergo surgery at least three weeks after enrollment;\n3. Age ≥ 18 years;\n4. Provide written informed consent;\n5. Willing and able to use smartphone application.\n\nExclusion Criteria:\n\n1. Presenting with very poor functional capacity;\n2. American Society of Anesthesiologists (ASA) physical status classes 5-6;\n3. Disabling orthopedic, neuromuscular, and psychiatric diseases or other conditions that preclude participation in a prehabilitation program.","ALL","18 Years",{"count":113,"type":114},600,"ESTIMATED","INTERVENTIONAL",[117],"NA","Cancer patients require chronic management and care. For those individuals living with cancer, a comprehensive approach that acknowledges the interdisciplinary nature of their condition can help guide appropriate care strategies and support their overall well-being. Approximately 45% of patients diagnosed with cancer undergo surgery to remove their tumor. Despite the advancements in surgical techniques, anesthesia, and perioperative care, major cancer surgeries still pose a significant challenge leading to a considerable decline in physiological and functional capacity. Traditionally, efforts focused on postoperative rehabilitation to enhance recovery. Recently, prehabilitation, a form of rehabilitation which aims to improve functional capacity before surgery, has gained attention for its potential benefits in improving surgical outcomes. However, prehabilitation lacks objective assessment measures to evaluate its effectiveness. Developing validated outcome measures is essential to enhance the impact of prehabilitation on surgical outcomes and long-term care for cancer patients. Heart rate variability (HRV) is a physiological parameter that measures the variation in time intervals between consecutive heartbeats, reflecting the autonomic nervous system activity which might serve as a valuable solution for objective outcome measures in evaluating the effectiveness of prehabilitation for cancer patients, providing an objective tool to assess and monitor physiological response to stress, recovery capacity, and autonomic nervous system activity. A multicenter randomized controlled trial will be conducted to assess the impact of a multimodal prehabilitation program on HRV. Patients aged 18 or older, scheduled for elective major cancer surgery will be randomized to receive either prehabilitation or standard care. The prehabilitation arm will receive a program involving home-based physical, nutritional, and psychological interventions for at least four weeks. Participants allocated to the control group will receive usual care. Patients will be followed throughout the study using an innovative mobile application, allowing for real-time monitoring and data collection during the prehabilitation program. The study has two primary outcomes: A) to assess the impact of prehabilitation on increasing preoperative HRV in chronic cancer patients undergoing surgery; B) to assess the effect of prehabilitation on length of hospital stay.",[120],"Cancer Surgery",[122,9,22,123,124,125,126,127,128,129,130,131],"Cancer surgery","Standard care treatment","Hospital stay","Functional walking","Nutrition","Diet","Exercise","Relaxation","Functional recovery","Anesthesiology","2025-08-05",{"date":134,"type":135},"2025-08-06","ACTUAL",{"date":137,"type":135},"2024-12-20",{"date":139,"type":114},"2026-11",{"name":5,"class":6},4]