[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633323":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":31,"responsibleParty":51,"collaborators":18,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":18,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":18,"overallStatus":33,"whyStopped":18,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"East Carolina University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Choline Nutrition Education","EXPERIMENTAL","Participants will receive choline nutrition education (CNE) between gestational weeks 16 through 36.",[13],"Behavioral: Choline nutrition education (CNE)",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual Care","NO_INTERVENTION","Usual care, control group. Participants will receive the intervention materials at 36 weeks of gestation after completion of all 36-wk measures.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Choline nutrition education (CNE)","All choline nutrition education (CNE) will be delivered virtually once every 4 weeks at Gestational Week 18, 22, 26, 30, and 34. Participants will also receive a check-in message at Gestational Week 20, 24, 28, and 32, asking them to confirm that they have read through the CNE materials and if they have any questions.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Ericka M Biagioni, PhD, RDN","CONTACT","252-737-5043","biagionie24@ecu.edu",[32],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Greenville","North Carolina","27858","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-77.36635,35.61266,{"lat":43,"lon":42},[46,47],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},{"name":48,"role":28,"phone":49,"phoneExt":18,"email":50},"Linda May, MS, PhD","252-737-7072","mayl@ecu.edu",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Ericka Biagioni","Principal Investigator","100633323","prenatal-choline-and-infant-outcomes-study-100633323",false,"NCT07525193","PREnatal Choline and Infant Outcomes Study","PRECIOUS","Inclusion Criteria:\n\n* Healthy pregnant individual\n* Singleton pregnancy\n* 18-40 years of age\n* Pre-pregnancy BMI ≥ 18.5\n\nExclusion Criteria:\n\n* Any non-pregnancy-related illness or chronic condition that may impact fetal development (i.e., HIV, cancer, heart disease, pre-existing diabetes) or known fetal anomaly\n* Food allergy to choline-rich foods (i.e., eggs)\n* Multi fetal pregnancy\n* \\>40 years of age",true,"FEMALE","18 Years","40 Years",{"count":67,"type":68},102,"ESTIMATED","INTERVENTIONAL",[71],"NA","Less than 10% of pregnant women consume adequate levels of choline, an essential nutrient for maternal lipid metabolism, placental efficiency, and fetal development. Most prenatal vitamins do not contain choline; a research survey shows that only 6% of OB\u002FGYNs were likely to recommend choline-rich foods to pregnant women. Nutrition education grounded in the Health Belief Model (HBM) has high efficacy among pregnant women; therefore, it is likely that HBM-driven choline education intervention will increase maternal choline levels. No studies have evaluated the influence of prenatal choline education intervention on maternal, placental, and neonatal outcomes. Our preliminary data suggest that increased choline intake corresponds with lower maternal body fat percentage (BF%), infant 1-month BF%, and MSC lipid accumulation, as well as increased placental efficiency. The central hypothesis is that choline education will increase maternal choline levels and improve placental function and infant health. We will test this hypothesis with three aims: to determine the influence of choline education intervention on maternal choline intake, placental efficiency, and infant health at the whole-body and cellular levels. The proposed study will be the first to provide a critical translational understanding of the influence of prenatal choline education intervention on maternal, placental, and child health.",[74],"Nutrition During Pregnancy","2026-04-06",{"date":77,"type":78},"2026-04-13","ACTUAL",{"date":80,"type":78},"2025-05-15",{"date":82,"type":68},"2027-05-14",{"name":5,"class":6},1]