[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100479523":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":32,"responsibleParty":52,"collaborators":55,"id":97,"slug":98,"hasResults":99,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":99,"sex":105,"minAge":106,"maxAge":10,"enrollmentInfo":107,"targetDuration":110,"studyType":111,"phases":10,"briefSummary":112,"conditions":113,"keywords":118,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Implementation cohort",null,"Inclusion criteria:\n\n1. Age ≥18 years;\n2. Pathology confirmed LAPC\\*;\n3. CT-based non-progressive disease in accordance with the RECIST criteria after at least 4 months of systemic chemotherapy (\\[m\\]FOLFIRINOX or gemcitabine-nab-paclitaxel).\n\nExclusion criteria:\n\n(1) Metastatic pancreatic cancer prior to induction chemotherapy.\n\n\\*According to the Dutch Pancreatic Cancer Group (DPCG) definition: \\>90 degrees arterial tumor involvement (i.e. superior mesenteric artery, celiac axis, and\u002For hepatic artery) and\u002For portovenous involvement of either \\>270 degrees or occlusion.",[13],"Other: Implementation - International best-practice care",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Implementation - International best-practice care","The PREOPANC-4 project aims to safely implement the international standard of excellence for LAPC management and surgery using a multidisciplinary best-practice training program, based on the experiences of four leading international expert centers (i.e. NYU Langone Health, University of Colorado, Heidelberg University, and MD Anderson Cancer Center). We hypothesize that the PREOPANC-4 implementation project will result in the improvement in multidisciplinary patient management and selection in line with current international best-practice.",[9],[20],{"name":21,"affiliation":5,"role":22},"Marc G Besselink, MD, MSc, PhD","PRINCIPAL_INVESTIGATOR",[24,29],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Thomas F Stoop, MD","CONTACT","+316 547 555 11","t.f.stoop@amsterdamUMC.nl",{"name":21,"role":26,"phone":30,"phoneExt":10,"email":31},"+316 16 15 83 45","m.g.besselink@amsterdamUMC.nl",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Amsterdam UMC, locatie AMC","RECRUITING","Amsterdam","North Holland","1105 AZ","Netherlands","NL",{"type":42,"coordinates":43},"Point",[44,45],4.88969,52.37403,{"lat":45,"lon":44},[48,49,50],{"name":21,"role":26,"phone":10,"phoneExt":10,"email":31},{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},{"name":51,"role":22,"phone":10,"phoneExt":10,"email":10},"Marc G Besselink, MD, PhD, MSc",{"type":22,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"M.G. Besselink","prof. dr. M.G. Besselink",[56,58,60,62,64,66,68,70,72,74,76,79,81,83,85,87,89,91,93,95],{"name":57,"class":6},"UMC Utrecht",{"name":59,"class":6},"Erasmus Medical Center",{"name":61,"class":6},"Leiden University Medical Center",{"name":63,"class":6},"University Medical Center Groningen",{"name":65,"class":6},"Radboud University Medical Center",{"name":67,"class":6},"Maastricht University Medical Center",{"name":69,"class":6},"Medisch Spectrum Twente",{"name":71,"class":6},"Isala",{"name":73,"class":6},"Frisius Medisch Centrum",{"name":75,"class":6},"Onze Lieve Vrouwe Gasthuis",{"name":77,"class":78},"Amphia ziekenhuis","UNKNOWN",{"name":80,"class":6},"Jeroen Bosch Ziekenhuis",{"name":82,"class":6},"Catharina Ziekenhuis Eindhoven",{"name":84,"class":6},"University of Colorado, Denver",{"name":86,"class":6},"Heidelberg University",{"name":88,"class":6},"M.D. Anderson Cancer Center",{"name":90,"class":6},"NYU Langone Health",{"name":92,"class":6},"Dutch Cancer Society",{"name":94,"class":6},"Maag Lever Darm Stichting",{"name":96,"class":78},"Deltaplan Alvleesklierkanker","100479523","preopanc-4-implementation-program-for-locally-advanced-pancreatic-cancer-100479523",false,"NCT05524090","PREOPANC-4 Implementation Program for Locally Advanced Pancreatic Cancer","Nationwide Implementation Program for Optimal Multidisciplinary Management and Resection of Locally Advanced Pancreatic Cancer (PREOPANC-4)","PREOPANC-4","Inclusion Criteria:\n\n* Age 18 years or older\n* Pathology-confirmed (LAPC)\\*\n* CT-based non-progressive disease (RECIST criteria) after at least 4 months of systemic chemotherapy (\\[m\\]FOLFIRINOX \u002F gemcitabine-nab-paclitaxel).\n\nExclusion Criteria:\n\n* Metastatic pancreatic cancer prior to induction chemotherapy.\n\n  * According to the Dutch Pancreatic Cancer Group (DPCG) definition: \\>90 degrees arterial tumor involvement (i.e. superior mesenteric artery, celiac axis, and\u002For hepatic artery) and\u002For portovenous involvement of either \\>270 degrees or occlusion.","ALL","18 Years",{"count":108,"type":109},223,"ESTIMATED","60 Months","OBSERVATIONAL","A prospective, nationwide, implementation program of the international standard of excellence for locally advanced pancreatic cancer (LAPC) care in the Netherlands (2021\\[7\\]-2030\\[6\\]), including a multidisciplinary training program by the four leading international expert centers.\n\nThe PREOPANC-4 project aims a safe and patient-centered implementation of the international standards of excellence for LAPC (surgery) in the Netherlands.",[114,115,116,117],"Pancreatic Cancer","Locally Advanced Pancreatic Adenocarcinoma","Pancreatic Adenocarcinoma Non-resectable","Chemotherapy Effect",[119,120,121,122,123],"Nationwide implementation International Best-Practice","The Netherlands","International Best-Practice","Patient Selection","Patient-centered","2022-08-29",{"date":126,"type":127},"2022-09-01","ACTUAL",{"date":129,"type":127},"2021-07-01",{"date":131,"type":109},"2030-12-31",{"name":5,"class":6},1]