[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100507233":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":59,"collaborators":18,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":18,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":18,"enrollmentInfo":72,"targetDuration":18,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":43,"whyStopped":18,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Western University, Canada","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ketogenic Diet Arm","EXPERIMENTAL","Participants in this group will be counselled by a registered dietician and then undergo a 4-week preoperative well formulated ketogenic diet. They will record all nutritional uptake during the diet using an app called Cronometer and provide weekly summary reports to the study team.",[13],"Dietary Supplement: Ketogenic Diet",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Arm","NO_INTERVENTION","Participants in this group will be counselled by a registered dietician and then undergo a 4-week standard of care diet, as recommended by Canada's Food Guide. They will record all nutritional uptake during the diet using an app called Cronometer and provide weekly summary reports to the study team.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DIETARY_SUPPLEMENT","Ketogenic Diet","4-week preoperative well-formulated very low carbohydrate isocaloric diet consisting of 50g net daily carbohydrates and 1.5g\u002Fkg protein with the remaining energy needs consisting of primarily mono- and polyunsaturated fats",[9],[26],{"name":27,"affiliation":28,"role":29},"Anton Skaro, MD PhD","London Health Sciences Centre\u002FLawson Health Research Institute","PRINCIPAL_INVESTIGATOR",[31,36],{"name":27,"role":32,"phone":33,"phoneExt":34,"email":35},"CONTACT","519-685-8500","32904","Anton.Skaro@lhsc.on.ca",{"name":37,"role":32,"phone":33,"phoneExt":38,"email":39},"Crystal Engelage, PhD","37517","Crystal.Engelage@lhsc.on.ca",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"London Health Sciences Centre\u002FWestern University","RECRUITING","London","Ontario","N6A 5A5","Canada","CA",{"type":50,"coordinates":51},"Point",[52,53],-81.23304,42.98339,{"lat":53,"lon":52},[56,57],{"name":37,"role":32,"phone":33,"phoneExt":38,"email":39},{"name":58,"role":29,"phone":18,"phoneExt":18,"email":18},"Anton Skaro, MD\u002FPhD",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Anton Skaro","Associate Professor Dept of Surgery","100507233","preoperative-ketogenic-diet-for-reduction-of-hepatic-steatosis-100507233",false,"NCT05884723","Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis","Implementation of a Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis Prior to Hepatectomy: a Randomized Control Trial","Inclusion Criteria:\n\n* Patients 18 years of age or older undergoing any type of liver resection (e.g. wedge, formal hepatectomy), either open or laparoscopic, for colorectal liver metastases (CRLM)\n* Patients with evidence of hepatic steatosis on pre-operative imaging (CT or MR) or biopsy.\n* Ability to use an app based nutritional program to track macronutrient uptake throughout the dietary intervention.\n\nExclusion Criteria:\n\n* Patients undergoing liver resection for any other indication\n* Patients on sodium glucose co-transporter 2 (SGLT-2) inhibitors (these are contraindicated with a ketogenic diet).\n* Patients without evidence of hepatic steatosis.\n* Patients with evidence of liver fibrosis or cirrhosis on preoperative bloodwork or imaging.\n* Patients with alcohol-related hepatic steatosis.\n* Patients with a known bleeding disorder.","ALL","18 Years",{"count":73,"type":74},124,"ESTIMATED","INTERVENTIONAL",[77],"NA","Non-alcoholic fatty liver disease is becoming increasingly common in Canada and throughout the world. Fatty liver can increase the risks of perioperative complications for those who need liver surgery. A ketogenic diet is low in carbohydrates and can be very effective in reducing liver fat content. The purpose of this randomized control trial is to compare the effect of a short duration (4 week) preoperative ketogenic diet on operative and disease outcomes in patients undergoing liver surgery. One arm will be randomized to the ketogenic diet and the other will receive standard of care pre-operative dietary consultation.",[80,81,82],"Liver Steatoses","Liver Metastasis Colon Cancer","NAFLD",[84,82,85],"ketogenic diet","colorectal liver metastases","2026-05-15",{"date":88,"type":89},"2026-05-19","ACTUAL",{"date":91,"type":89},"2024-05-01",{"date":93,"type":74},"2032-12",{"name":61,"class":6},1]