[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625261":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":57,"collaborators":25,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":25,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":25,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":25,"overallStatus":84,"whyStopped":25,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Indonesia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1 : Preoperative shoulder exercise","EXPERIMENTAL","Arm 1: Preoperative Shoulder Exercise Participants will receive a structured preoperative shoulder range-of-motion exercise program prior to modified radical mastectomy, in addition to standard preoperative care.",[13],"Behavioral: Preoperative shoulder exercise",{"label":15,"type":6,"description":16,"interventionNames":17},"Arm 2 : Standard Preoperative Care","Arm 2: Standard Preoperative Care Participants will receive standard preoperative care without a structured shoulder exercise program prior to modified radical mastectomy.",[18],"Other: Standard preoperative care",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Preoperative shoulder exercise","Arm 1 : Participants in the intervention arm will perform a structured preoperative shoulder range-of-motion exercise program prior to modified radical mastectomy. The exercises are designed to maintain shoulder mobility and are conducted in addition to standard preoperative care.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Standard preoperative care","Participants will receive standard preoperative care without a structured shoulder exercise program prior to modified radical mastectomy.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Freda S Halim, MD, Ph.D","CONTACT","+62812-99000-530","freda.susana@ui.ac.id",[37],{"facility":38,"status":25,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia","Jakarta Pusat","Dki Jakarta","10430","Indonesia","ID",{"type":45,"coordinates":46},"Point",[47,48],106.8223,-6.1818,{"lat":48,"lon":47},[51,55],{"name":52,"role":33,"phone":53,"phoneExt":25,"email":54},"Sonar Soni Panigoro, MD, Ph.D","+62-812-9502-754","sonar.soni@ui.ac.id",{"name":56,"role":33,"phone":25,"phoneExt":25,"email":25},"Sonar Soni Panigoro, MD,Ph.D",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":61,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Freda Susana Halim","Surgical Oncology Trainee","Fakultas Kedokteran Universitas Indonesia","100625261","preoperative-shoulder-exercises-and-postoperative-inflammation-pain-and-function-after-modified-radical-mastectomy-100625261",false,"NCT07420335","Preoperative Shoulder Exercises and Postoperative Inflammation, Pain, and Function After Modified Radical Mastectomy","The Effect of Preoperative Shoulder Range-of-Motion Exercises on C-Reactive Protein (CRP) Levels, Pain, and Shoulder Joint Dysfunction, as Well as Quality of Life in Patients With Locally Advanced Breast Cancer After Modified Radical Mastectomy","Inclusion Criteria:\n\n* Patients with clinically locally advanced breast cancer (stage IIIA-IIIC according to the American Joint Committee on Cancer staging system) who have been scheduled to undergo modified radical mastectomy.\n* Age ≥ 18 years at the time of diagnosis\n* Willing to undergo preoperative rehabilitation for 6-8 weeks and to perform the recommended home-based exercise program.\n* Willing to participate in follow-up via telephone.\n\nExclusion Criteria:\n\n* Inability to understand verbal or written communication, resulting in difficulty following exercise instructions.\n* Intraoperative complications, such as injury to or transection of the thoracodorsal nerve, long thoracic nerve, and\u002For intercostobrachial nerve.\n* Postoperative complications leading to delayed wound healing, defined as incomplete wound healing at one month after surgery, including wound dehiscence, wound infection, or abscess formation.\n* Pre-existing shoulder joint motion limitation diagnosed prior to surgery (e.g., preoperative frozen shoulder).\n* Presence of inflammatory conditions in other body regions at the start of or during the study that may result in elevated leukocyte counts, such as diarrhea, urinary tract infection, or skin infection.\n* Requirement for nonsteroidal anti-inflammatory drugs (NSAIDs) or systemic corticosteroids for the management of inflammation.\n\nDrop out criteria:\n\n* incomplete follow up\n* Unwillingness to undergo repeated blood sampling during the study period.",true,"FEMALE","18 Years","70 Years",{"count":74,"type":75},52,"ESTIMATED","INTERVENTIONAL",[78],"NA","This study evaluates whether preoperative shoulder range-of-motion exercises influence postoperative inflammatory response, pain, shoulder function, and quality of life in patients with locally advanced breast cancer undergoing modified radical mastectomy.",[81,82,83],"Locally Advanced Breast Cancer (LABC)","Postoperative Inflammation","Prehabilitation","NOT_YET_RECRUITING","2026-02-12",{"date":87,"type":88},"2026-02-19","ACTUAL",{"date":90,"type":75},"2026-01-21",{"date":92,"type":75},"2026-12-03",{"name":5,"class":6},1]