[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100481131":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":42,"responsibleParty":167,"collaborators":169,"id":173,"slug":174,"hasResults":175,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":175,"sex":181,"minAge":182,"maxAge":26,"enrollmentInfo":183,"targetDuration":26,"studyType":186,"phases":187,"briefSummary":189,"conditions":190,"keywords":192,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":206},{"fullName":5,"class":6},"Istituto Clinico Humanitas","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"HSRS pre-operative","EXPERIMENTAL","Patients undergo HSRS (hypofractionated Radiosurgery) on day 1, consisting in 27 Gray (gy) administered in 3 daily fractions.\n\nWithin 1 weeks, patients undergo surgical resection.",[13,14],"Radiation: Hypofractionated Radiosurgery (HSRS)","Procedure: Brain metastases surgical resection",{"label":16,"type":17,"description":18,"interventionNames":19},"HSRS post-operative","ACTIVE_COMPARATOR","Patients undergo surgical resection on day 1. 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I","ACTIVE_NOT_RECRUITING","Rome","00161",{"type":51,"coordinates":126},[127,128],12.51133,41.89193,{"lat":128,"lon":127},{"facility":131,"status":45,"city":123,"state":123,"zip":132,"country":48,"countryCode":49,"cosmosGeoPoint":133,"geoPoint":135,"contacts":136},"Fondazione Policlinico Universitario Agostino Gemelli","00168",{"type":51,"coordinates":134},[127,128],{"lat":128,"lon":127},[137,140],{"name":138,"role":35,"phone":26,"phoneExt":26,"email":139},"Silvia Chiesa, MD, radiation oncologist","silvia.chiesa@policlinicogemelli.it",{"name":138,"role":61,"phone":26,"phoneExt":26,"email":26},{"facility":142,"status":45,"city":123,"state":123,"zip":143,"country":48,"countryCode":49,"cosmosGeoPoint":144,"geoPoint":146,"contacts":147},"AOU Sant'Andrea","00189",{"type":51,"coordinates":145},[127,128],{"lat":128,"lon":127},[148,151],{"name":149,"role":35,"phone":26,"phoneExt":26,"email":150},"Anna Maria Ascolese, MD, radiation oncologist","aascolese@ospedalesantandrea.it",{"name":149,"role":61,"phone":26,"phoneExt":26,"email":26},{"facility":153,"status":45,"city":154,"state":154,"zip":155,"country":48,"countryCode":49,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"Azienda Ospedaliera Santa Maria di Terni","Terni","05100",{"type":51,"coordinates":157},[158,159],12.64329,42.56335,{"lat":159,"lon":158},[162,165],{"name":163,"role":35,"phone":26,"phoneExt":26,"email":164},"Paola Anselmo, MD, radiation oncologist","p.anselmo@aospterni.it",{"name":166,"role":61,"phone":26,"phoneExt":26,"email":26},"Fabio Trippa, MD, radiation oncologist",{"type":168,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[170],{"name":171,"class":172},"Brainlab AG","INDUSTRY","100481131","preoperative-vs-postoperative-hypofractionated-radiosurgery-for-patients-with-large-brain-metastases-100481131",false,"NCT05545007","Preoperative vs Postoperative 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Lymphoproliferative disease\n* Pregnant women\n* Prior open neurosurgery for malignancy\n* More than 4 brain metastases\n* Patients with incompatibility to perform MRI","ALL","18 Years",{"count":184,"type":185},146,"ESTIMATED","INTERVENTIONAL",[188],"NA","This is a phase III randomized trial with the aim to compare preoperative HSRS to postoperative HSRS in patients with large at least one BMs from solid tumors suitable for surgical resection.",[191],"Brain Metastases, Adult",[193,194,195,196],"pre-operative hypofractionated radiosurgery","surgical resection","large brain metastases","post-operative hypofractionated radiosurgery","2026-04-24",{"date":199,"type":200},"2026-04-30","ACTUAL",{"date":202,"type":200},"2023-01-31",{"date":204,"type":185},"2027-01",{"name":5,"class":6},9]