[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617269":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":34,"responsibleParty":109,"collaborators":111,"id":117,"slug":118,"hasResults":119,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":119,"sex":125,"minAge":126,"maxAge":18,"enrollmentInfo":127,"targetDuration":18,"studyType":130,"phases":131,"briefSummary":133,"conditions":134,"keywords":139,"overallStatus":37,"whyStopped":18,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":151},{"fullName":5,"class":6},"Umeå University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","The intervention group participates in a home-based, multimodal prehabilitation programme addressing physical inactivity, obesity, inadequate management of comorbidities, smoking, and alcohol consumption.",[13],"Procedure: preoptimisation programme",{"label":15,"type":16,"description":17,"interventionNames":18},"control","NO_INTERVENTION","The control group will receive basic guidance on physical activity and weight management during the preoperative consultation.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","preoptimisation programme","The intervention group follows a home-based, multimodal prehabilitation programme targeting physical inactivity, obesity, comorbidities, smoking, and alcohol use. Designed to suit both rural and urban populations in northern Sweden, the programme lasts for a minimum of three months before surgery.",[9],[26,31],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Gunnar Nordqvist, M.D.","CONTACT","+46768227094","gunnar.nordqvist@umu.se",{"name":32,"role":28,"phone":18,"phoneExt":18,"email":33},"Viktor Holmdahl, Phd","viktor.holmdahl@umu.se",[35,54,67,84,98],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Gällivare hospital","RECRUITING","Gällivare","Norrbotten County","98238","Sweden","SE",{"type":44,"coordinates":45},"Point",[46,47],20.65278,67.13387,{"lat":47,"lon":46},[50],{"name":51,"role":28,"phone":52,"phoneExt":18,"email":53},"Gunnar Nordqvist, MD","004697019876","gunnar.nordqvist@norrbotten.se",{"facility":55,"status":37,"city":56,"state":39,"zip":57,"country":41,"countryCode":42,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"Sunderby Hospital","Luleå","94542",{"type":44,"coordinates":59},[60,61],22.15465,65.58415,{"lat":61,"lon":60},[64,65],{"name":51,"role":28,"phone":29,"phoneExt":18,"email":53},{"name":66,"role":28,"phone":18,"phoneExt":18,"email":53},"Nordqvist",{"facility":68,"status":69,"city":70,"state":71,"zip":72,"country":41,"countryCode":42,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Lycksele Hospital","NOT_YET_RECRUITING","Lycksele","Västerbotten County","92137",{"type":44,"coordinates":74},[75,76],18.67351,64.59537,{"lat":76,"lon":75},[79,82],{"name":80,"role":28,"phone":81,"phoneExt":18,"email":33},"Viktor Holmdahl, MD, Phd","+46730724411",{"name":83,"role":28,"phone":18,"phoneExt":18,"email":33},"Holmdahl",{"facility":85,"status":69,"city":86,"state":71,"zip":87,"country":41,"countryCode":42,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"Skellefteå Hospital","Skellefteå","93141",{"type":44,"coordinates":89},[90,91],20.95279,64.75067,{"lat":91,"lon":90},[94],{"name":95,"role":28,"phone":96,"phoneExt":18,"email":97},"Mikael Lindmark, MD, Phd","0046739649215","mikael.lindmark@umu.se",{"facility":99,"status":37,"city":100,"state":71,"zip":18,"country":41,"countryCode":42,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Umeå University Hospital","Umeå",{"type":44,"coordinates":102},[103,104],20.25972,63.82842,{"lat":104,"lon":103},[107],{"name":80,"role":28,"phone":108,"phoneExt":18,"email":33},"0046730724411",{"type":110,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[112,114],{"name":113,"class":6},"Region Norrbotten",{"name":115,"class":116},"Region Västerbotten","OTHER_GOV","100617269","preoptimisation-in-ventral-hernia-surgery-100617269",false,"NCT07316426","Preoptimisation in Ventral Hernia Surgery","Preoptimisation in Ventral Hernia Surgery- a Randomised Trial","PreOpt","Inclusion Criteria:\n\n* Patients with a ventral hernia with a defect width of at least 4 cm.\n* Symptom burden related to the hernia sufficient to justify surgical intervention.\n* Age ≥ 18 years.\n\nExclusion Criteria:\n\n* Expected survival of less than three years.\n* Inability to comprehend oral and written information or to provide informed consent.\n* Acute complication of the hernia requiring emergency surgical intervention.\n* General condition characterised by severe limitations in physical functional capacity.","ALL","18 Years",{"count":128,"type":129},130,"ESTIMATED","INTERVENTIONAL",[132],"NA","The study is a multicentre, single-blinded, randomised controlled trial. Ventral hernia patients with an aperture width between four and eight centimetres are randomised to either participation in a multimodal preoptimisation programme, including interventions to increase physical activity, promote weight loss, and optimise the treatment of comorbidities, or to surgery without structured preoptimisation. The primary endpoint is complications at three months postoperatively. During surgery, biopsies of skin, muscle, and fascia will be collected, along with pre- and postoperative blood samples, to analyse the molecular effects of preoptimisation, particularly in relation to collagen metabolism.",[135,136,137,138],"Hernia","Hernia, Ventral","Hernia Incisional","Hernia, Umbilical",[140,141],"preoptimisation","prehabilitation","2025-12-18",{"date":144,"type":145},"2026-01-05","ACTUAL",{"date":147,"type":145},"2025-09-22",{"date":149,"type":129},"2029-09-01",{"name":5,"class":6},5]