[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642514":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":28,"responsibleParty":51,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":68,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":78,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Clarkson University","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"hypermobile - symptomatic",null,"People who meet the diagnostic criteria for hEDS or HSD",{"label":13,"type":10,"description":14,"interventionNames":10},"non-hypermobile","People who do not meet the diagnostic criteria for generalized joint laxity, hEDS or HSD",{"label":16,"type":10,"description":17,"interventionNames":10},"hypermobile - non-symptomatic","People with generalized joint laxity but not meeting diagnostic criteria for hEDS\u002FHSD",[19,24],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Leslie N Russek, PT, DPT, PhD","CONTACT","315-212-2851","Lrussek@clarkson.edu",{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},"Samantha Marocco, PT, DPT, EdD","315-268-7622","smarocco@clarkson.edu",[29],{"facility":30,"status":10,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Clarkson University, Lewis School of Health & Life Sciences","Potsdam","New York","13699","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-74.98131,44.66978,{"lat":40,"lon":39},[43,44,48],{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},{"name":45,"role":21,"phone":46,"phoneExt":10,"email":47},"Heather Shattuck, PT, DPT","315-268-3786","hshattuc@clarkson.edu",{"name":49,"role":50,"phone":10,"phoneExt":10,"email":10},"Leslie Russek, PT, DPT, PhD","PRINCIPAL_INVESTIGATOR",{"type":50,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Leslie Russek","Professor Emerita","100642514","presentation-of-young-adults-with-and-without-joint-hypermobility-100642514",false,"NCT07657507","Presentation of Young Adults With and Without Joint Hypermobility","Prospective Study of Symptoms in People With and Without Joint Hypermobility","Inclusion Criteria: Clarkson University Health Sciences students. -\n\nExclusion Criteria: Other physical conditions that preclude collecting \\>25% of physical measurements at initial data collection.\n\n\\-",true,"ALL","18 Years","60 Years",{"count":66,"type":67},100,"ESTIMATED","5 Years","OBSERVATIONAL","People with multiple hypermobile joints are diagnosed with Generalized Joint Hypermobility (GJH) when asymptomatic, or Hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorder (HSD) when symptomatic (hEDS\u002FHSD, or 'HSD' here). GJH likely affects about 20% of the U.S. population, while HSD affects 0.5-3% of the US population. Although joint hypermobility is the most visible presentation of HSD, it is a systemic connective tissue disorder affecting multiple body systems. Due to frequent health concerns, HSD may contribute to more than 30% of patients in chronic pain, rheumatology, orthopedic and physical therapy clinics. It is still unclear why some people have asymptomatic hypermobility and others develop complex chronic health issues. However, recent research suggests that the transition might be triggered by severe physiological stress, such as viral infection.\n\nHSD is commonly associated with Postural Orthostatic Tachycardia Syndrome (POTS) and Mast Cell Activation Syndrome (MCAS), as well as gastrointestinal (GI) problems. Recent research suggests that persistent inflammation due to MCAS or COVID may trigger HSD symptoms. The correlation between POTS and HSD may be due to effects of HSD on the autonomic nervous system or to inflammation triggering both conditions. It is also unclear whether body awareness and coordination deficits seen in symptomatic HSD are due to the fundamental connective tissue disorder or due to pain and injuries in HSD. This study seeks to determine whether asymptomatic hypermobile individuals (GJH) also have balance and coordination deficits. The current study hopes to identify factors that correlate with a transition from asymptomatic GJH to symptomatic HSD by following a group of Health Science students forward in time. The study will collect baseline health information including relevant diagnoses, symptoms and function. Physical measurements will include standard clinical tests performed by physical therapists: joint hypermobility and instability, standing balance, neck movement control, and heart rate in response to standing from lying down. The study is likely to last for at least 10 years to follow participants over time.",[72,73],"Hypermobile Ehlers-Danlos Syndrome","Postural Orthostatic Tachycardia Syndrome (POTS)",[75,76,77],"hypermobile Ehlers-Danlos Syndrome","Hypermobility Spectrum Disorders","Risk factors","NOT_YET_RECRUITING","2026-06-17",{"date":81,"type":82},"2026-06-22","ACTUAL",{"date":84,"type":67},"2026-06-20",{"date":86,"type":67},"2036-06-20",{"name":5,"class":6},1]