[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556804":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":45,"locations":55,"responsibleParty":76,"collaborators":25,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":25,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":25,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":25,"overallStatus":58,"whyStopped":25,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Cairo University","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Normal Healthy children","EXPERIMENTAL","All forty normal healthy children will undergo measurement of pressure pain tolerance via digital pressure algometry, balance assessment using HUMAC balance system, and evaluation lower limb strength using Lafayette Hand Held Dynamometer.",[13,14,15],"Other: Pressure pain tolerance measurement using Digital Pressure Algometer","Other: Balance assessment using HUMAC balance system","Other: Lower limb muscular strength using Lafayette hand held dynamometer",{"label":17,"type":10,"description":18,"interventionNames":19},"Sickle cell anemia children","All forty Sickle cell anemia children will undergo measurement of pressure pain tolerance via digital pressure algometry, balance assessment using HUMAC balance system, and evaluation lower limb strength using Lafayette Hand Held Dynamometer.",[13,14,15],[21,26,30],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Pressure pain tolerance measurement using Digital Pressure Algometer","Pressure pain tolerance will be measured using pressure algometer for all participants in both groups. Pressure pain tolerance will be measured in a relaxed sitting position to evaluate on quadriceps muscle. Initially, a teddy bear will be used for demonstration.",[9,17],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Balance assessment using HUMAC balance system","HUMAC balance system will be calibrated, then will conduct\n\n1. center of pressure: will instructed child to stand on platform, and maintain own body stability, and focus on the red dot in the center of screen that will move in response to body sway. after a rest, second trial will be done.\n2. Eye open\u002F closed firm surface tests: First for Eye open firm surface test; the child will be asked to look at a target on the wall that was set at his\u002F her eye level, and to stare at this target for 30 seconds while standing on firm surface. After 5 seconds rest. Eye closed firm surface test; child will be asked to close his\u002F her eyes for 30 seconds, and conducting the same procedures for balance testing.\n\nThe researcher will documented the values resented on the screen .",[9,17],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Lower limb muscular strength using Lafayette hand held dynamometer","Lower limb muscular ' Isometric quadriceps strength' will be measured for all participants in both groups. each participating child will be instructed to sit to assess the strength of knee extension, which minimize positional changes, and enhance feasibility of this clinical test. then The researcher will apply resistance to child's quadriceps to gain maximal voluntary isometric contraction with pressing the activated Lafayette hand held dynamometer padded stirrup against quadriceps belly, then recorded and documented measured value.",[9,17],[35],"Isometric quadriceps strength'",[37,41],{"name":38,"affiliation":39,"role":40},"Shimaa A Ahmed, PHD","Head of Haematology Dept, Faculty of Medicine, Alexandria University","STUDY_CHAIR",{"name":42,"affiliation":43,"role":44},"Elham M Salem, PHD","Professor of Physical Therapy, Faculty of Physical Therapy, Cairo University","STUDY_DIRECTOR",[46,51],{"name":47,"role":48,"phone":49,"phoneExt":25,"email":50},"Mahmoud M Metwaly, MD","CONTACT","0102572862","malmanakhly10@gmail.com",{"name":52,"role":48,"phone":53,"phoneExt":25,"email":54},"Nanees E Salem, PHD","0115960603","naness.essam@gmail.com",[56],{"facility":57,"status":58,"city":59,"state":25,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"El-Tahrir st.- in front of Ben El-Sarayat, Ad Doqi Al Giza, Giza Governate","RECRUITING","Giza","002","Egypt","EG",{"type":64,"coordinates":65},"Point",[66,67],31.20861,30.00944,{"lat":67,"lon":66},[70,73],{"name":47,"role":48,"phone":71,"phoneExt":25,"email":72},"01025702861","mamanakhly18@gmail.com",{"name":52,"role":48,"phone":74,"phoneExt":25,"email":75},"01115960603","naness.esam@gmail.com",{"type":77,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Adly A Adam","Lecturer Physical Therapy","100556804","pressure-pain-tolerance-in-relation-to-balance-and-strength-in-children-100556804",false,"NCT06529874","Pressure Pain Tolerance in Relation to Balance and Strength in Children","Pressure Pain Tolerance in Relation to Balance and Strength in Children With Sickle Cell Anemia","Inclusion Criteria:\n\n* Age range range was 9-14 years old.\n* Could follow given instructions.\n* Children with Sickle cell anemia were medically stable, and take their medications regularly.\n* Children with Sickle cell anemia had experience of chronic pain that lasts more than 6 months.\n* All children with Sickle cell anemia have average weight, height, and body mass index based on their age percentiles.\n* All normal healthy children did not participating in regular sport activities, particularly including lower limb strengthening.\n\nExclusion Criteria:\n\n* Defined cardiovascular or respiratory disorders.\n* Renal failure.\n* Myocardial infarction, mainly within last month.\n* Unstable angina.\n* Recent thoracoabdominal surgery.\n* Thoracic or abdominal aneurysm or current pneumothorax.\n* Painful vaso-occlusive crises.\n* Muscular contractures, Joints' stiffness, or deformities.\n* Neuromuscular problems i.e., myositis or peripheral neuropathy.",true,"ALL","9 Years","14 Years",{"count":92,"type":93},80,"ESTIMATED","INTERVENTIONAL",[96],"NA","Sickle cell disease (SCD) is the most frequent life-threatening genetic hemoglobinopathy in the world and occurs due to the synthesis of abnormal hemoglobin S (HbS).Cells with sickle cell hemoglobin are stiff and sticky. When they lose their oxygen, they form into the shape of a sickle or crescent. This can cause pain and tissue damage. Significant decrease in exercise capacity was seen in sickle cell anemic children. In the absence of a guidelines that can guide the prescription of exercise in SCD children. This study is a step for determine the forms of prescription of pain on the balance and muscle strength to build up in future studies a safety of physical exercises for children with sickle cell anemia and improve their functional abilities.",[99],"Sickle Cell Anemia","2025-03-26",{"date":102,"type":103},"2025-04-01","ACTUAL",{"date":105,"type":103},"2024-02-01",{"date":107,"type":93},"2025-08-30",{"name":78,"class":6},1]