[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100513064":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":106,"collaborators":110,"id":114,"slug":115,"hasResults":116,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":116,"sex":122,"minAge":123,"maxAge":10,"enrollmentInfo":124,"targetDuration":10,"studyType":127,"phases":10,"briefSummary":128,"conditions":129,"keywords":135,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":156},{"fullName":5,"class":6},"Recep Tayyip Erdogan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low cardiac reserve\u002Fefficiency",null,"Patients who were identified as having low cardiac reserve and efficiency, based on PRAM parameters.",[13],"Diagnostic Test: Passive leg raising",{"label":15,"type":10,"description":16,"interventionNames":17},"Normal cardiac reserve\u002Fefficiency","Patients who were identified as having normal cardiac reserve and efficiency, based on PRAM parameters.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Passive leg raising","All patients who met the inclusion criteria will be placed head down flat and feet up at a 45° angle for 30 seconds.\n\nHemodynamic parameters and analysis by pressure recording analytical method obtained with the MostCare will be collected before, during and after the test until the end of the surgery.\n\nThe total duration of the intervention (passive leg raising) is 30 seconds. The total duration of hemodynamic parameters recording is expected to be 60-600 minutes.",[9,15],[25],{"name":26,"affiliation":27,"role":28},"Fevzi Toraman, Prof.","Acibadem University","STUDY_DIRECTOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Başar Erdivanlı, Assoc. Prof.","CONTACT","+90-505-7800730","basar.erdivanli@erdogan.edu.tr",[36,53,67,81,92],{"facility":37,"status":38,"city":39,"state":10,"zip":40,"country":41,"countryCode":10,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Gazi University Medical Faculty, Department of Anesthesiology and Reanimation","RECRUITING","Ankara","06560","Turkey (Türkiye)",{"type":43,"coordinates":44},"Point",[45,46],32.85427,39.91987,{"lat":46,"lon":45},[49],{"name":50,"role":32,"phone":51,"phoneExt":10,"email":52},"Aycan Özdemirkan, Assoc. Prof.","+90-532-7884107","aycan.k@gmail.com",{"facility":54,"status":38,"city":55,"state":10,"zip":56,"country":41,"countryCode":10,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"Erzurum Atatürk University Medical Faculty, Department of Anesthesiology and Reanimation","Erzurum","25240",{"type":43,"coordinates":58},[59,60],41.27694,39.90861,{"lat":60,"lon":59},[63],{"name":64,"role":32,"phone":65,"phoneExt":10,"email":66},"Enes Aydın, Assoc. Prof.","+90-554-3318289","EnesMD@msn.com",{"facility":68,"status":38,"city":69,"state":10,"zip":70,"country":41,"countryCode":10,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Başakşehir Çam ve Sakura City Hospital, University Medical Faculty, Anesthesiology and Reanimation Clinic","Istanbul","34480",{"type":43,"coordinates":72},[73,74],28.94966,41.01384,{"lat":74,"lon":73},[77],{"name":78,"role":32,"phone":79,"phoneExt":10,"email":80},"Taner Abdullah, Asst. Prof","+90-537-5199544","taner.abdullah@gmail.com",{"facility":82,"status":38,"city":69,"state":10,"zip":83,"country":41,"countryCode":10,"cosmosGeoPoint":84,"geoPoint":86,"contacts":87},"Acıbadem University Medical Faculty, Department of Anesthesiology and Reanimation","34755",{"type":43,"coordinates":85},[73,74],{"lat":74,"lon":73},[88],{"name":89,"role":32,"phone":90,"phoneExt":10,"email":91},"Fevzi Toraman, Prof. Dr.","+90-216-5004444","ftoraman@gmail.com",{"facility":93,"status":94,"city":95,"state":10,"zip":96,"country":41,"countryCode":10,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"Recep Tayyip Erdogan University Medical Faculty, Department of Anesthesiology and Reanimation","NOT_YET_RECRUITING","Rize","53100",{"type":43,"coordinates":98},[99,100],40.52194,41.02083,{"lat":100,"lon":99},[103],{"name":31,"role":32,"phone":104,"phoneExt":105,"email":34},"+90-464-2130491","2128",{"type":107,"investigatorFullName":108,"investigatorTitle":109,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Başar Erdivanlı","Assoc. Prof. Başar Erdivanlı",[111],{"name":112,"class":113},"Turkish Society of Thoracic and Cardio-Vascular Anesthesia and Intensive Care","UNKNOWN","100513064","pressure-recording-analytical-method-parameters-and-their-relationship-with-hypotension-in-hypertensive-patients-100513064",false,"NCT05960604","Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients","Observational Study to Evaluate the Pressure Recording Analytical Method Parameters in Patients Susceptible to Post-induction Hypotension Due to Hypertension, Diabetes Mellitus, Cardiovascular Risk Factors, or Major Surgery","PRAM-in-HYPO","Inclusion Criteria:\n\n* Age at least 18 years\n* Undergoing major surgery under general anesthesia\n* Expected surgery time \\>2 h\n* Expected length of postoperative stay \\>2 d\n* Invasive blood pressure (radial or femoral) and Mostcare monitoring\n* Indication for a passive leg raising test: risk of hypovolemia (preoperative fasting, bowel preparation, loss of appetite, limited access to water) or expected major surgery, expected blood loss, cardiovascular comorbidity (hypertension, diabetes mellitus, coronary artery disease, peripheral artery disease, hyperlipidemia, morbidity, active smoking).\n* Recruitment after booking for surgery with sufficient time to read, understand and question study patient information prior to attending for surgery.\n* Ability and willingness to provide informed consent\n\nExclusion Criteria:\n\n* Refuse to consent to the study\n* Arterial wave form distortion\n* Cardiac arrhythmia\n* Inappropriate identification of the dicrotic notch for any reason\n* Planned intraoperative mean arterial blood pressure \\\u003C 65 mmHg\n* Hemodynamic instability defined as mean arterial blood pressure \\\u003C 65 mmHg\n* Preoperative requirement of inotrope\u002Fvasopressor infusion\n* Preoperatively receiving vasoactive drugs\n* Patients fitted with an intra-aortic balloon pump\n* Patients fitted with Extracorporeal Membrane Oxygenation\n* Critically ill patients requiring preoperative intensive care unit\n* Presence of intraabdominal hypertension\n* New York Heart Association Class 3-4 heart failure\n* Congestive heart failure with ejection fraction \\\u003C 35%\n* Glomerular filtration rate \\\u003C 30 ml\u002Fmin\u002F1.73 m2\n* Ongoing renal replacement therapy","ALL","18 Years",{"count":125,"type":126},660,"ESTIMATED","OBSERVATIONAL","Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management and improve patient outcomes. Parameters of the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy) of the MostCare system, specifically cardiac cycle efficiency has been proposed as such variables. Yet, their value in anesthesia and especially in hypertensive patients is not studied. The goal of the PRAM-in-HYPO study is to prospectively evaluate the relationship between cardiac reserve and efficiency and cardiovascular risk factors in patients wo will undergo major surgical procedures using the state-of-the-art hemodynamic monitors. Also the investigators aim to build a predictive model to identify patients with decreased cardiac reserve due to hypertension and other cardiovascular risk factors, who are susceptible to post-induction hypotension. The investigators seek to include high-risk patients or patients presenting for major surgery, who are monitored with an advanced hemodynamic monitor to adequately evaluate the differences in cardiac reserve and cardiac efficiency.",[130,131,132,133,134],"Cardiovascular Diseases","Surgery","Hypotension","Hypotension on Induction","Hypotension During Surgery",[136,137,138,139,140,141,142,143,144,145,146],"Mostcare","Pressure Recording Analytical Method","Pulse contour analysis","Hemodynamic monitoring","Effective arterial elastance","Cardiac cycle efficiency","Cardiac power output","Myocardial contraction","Cardiac output","Stroke volume","Systemic vascular resistance","2025-04-08",{"date":149,"type":150},"2025-04-09","ACTUAL",{"date":152,"type":150},"2024-02-19",{"date":154,"type":126},"2027-06",{"name":5,"class":6},5]