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Hospital","100459749","preterm-immune-system-development-and-response-to-immunization-100459749",false,"NCT05266664","Preterm Immune System Development and Response to Immunization","PRIMI","To be eligible to participate in this study, a preterm infant must meet all following criteria:\n\n* Preterm infant born at gestational age less than 32 weeks (whose mothers did or did not receive a T dap vaccination during pregnancy)\n* Parents\u002F guardians must have sufficient understanding of the Dutch language\n\nTo be eligible to participate in this study, a healthy full-term infant must meet all following criteria:\n\n* healthy full-term infant whose mother received a Tdap vaccination during pregnancy\n* Parents\u002F guardians must have sufficient understanding of the Dutch language\n\nTo be eligible to participate in this study, a mother must meet all following criteria:\n\n\\- Mother of preterm or health full-term infant who are participating in the study\n\nExclusion Criteria:\n\n* Parents\u002Fguardians of the infant are not able or willing to provide informed consent\n* Infant with congenital anomaly which are more likely to cause adverse effects after immunization (for example hemodynamically significant congenital heart defect)\n* Infant with a (possible) HIV infection or immunodeficiency\n* Maternal use of immunosuppressive drugs during pregnancy",true,"ALL","1 Day","2 Months",{"count":154,"type":155},145,"ESTIMATED","OBSERVATIONAL","In this study the response to vaccination and development of the immune system in very preterm infants upon the current vaccination schedule will be compared to healthy term infants.",[159,160,161],"Immune System Disorder","Preterm","Vaccination Failure",[163,164,165],"immune system development","preterm infant","vaccination","2024-03-19",{"date":168,"type":169},"2024-03-20","ACTUAL",{"date":171,"type":169},"2022-12-08",{"date":173,"type":155},"2026-07",{"name":5,"class":6},7]