[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552976":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":17,"locations":25,"responsibleParty":38,"collaborators":40,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":7,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":7,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":7,"overallStatus":67,"whyStopped":7,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Medisch Spectrum Twente","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Continuous Laryngoscopy during Exercise Test (CLE test)","A flexible fiberoptic laryngoscope (Olympus, Tokyo, Japan) is introduced directly through the nose or via a slightly modified Hans Rudolph facemask, and into the pharyngeal space. A modified Bruce protocol with a 60-second incremental intensity step is used (Appendix A) and heart rate is monitored. During the CLE test participants perform incremental exercise on a treadmill until symptom-limiting distress or exhaustion. Forced expiratory flow-volume loops are measured before, during and after the CLE test.",[14],{"name":15,"affiliation":5,"role":16},"Vera Hengeveld, MD","PRINCIPAL_INVESTIGATOR",[18,22],{"name":15,"role":19,"phone":20,"phoneExt":7,"email":21},"CONTACT","+31 53 487 23 10","vera.hengeveld@mst.nl",{"name":23,"role":19,"phone":20,"phoneExt":7,"email":24},"Mattienne van der Kamp, PhD","m.vanderkamp@mst.nl",[26],{"facility":5,"status":7,"city":27,"state":28,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":7},"Enschede","Overijssel","7512 KZ","Netherlands","NL",{"type":33,"coordinates":34},"Point",[35,36],6.89583,52.21833,{"lat":36,"lon":35},{"type":39,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[41],{"name":42,"class":6},"Haukeland University Hospital","100552976","prevalence-of-eilo-among-children-with-asthma-100552976",false,"NCT06480084","Prevalence of EILO Among Children With Asthma","The Prevalence of Exercise-Induced Laryngeal Obstruction (EILO) Amongst Children With Asthma' - a Prospective Cross-sectional Study","Inclusion Criteria:\n\n* Age 12 to 18 years\n* Paediatrician diagnosed asthma confirmed with at least one of the following during the last two years: Positive ECT (post-exercise fall in FEV1 \\> 10%) \u002F Positive methacholine test (PC20 value of ≤8 mg\u002FmL) \u002F Bronchodilator reversibility (increase in FEV1 ≥12% and\u002For ≥200 mL following inhalation of 200-400 μg short-acting β2-agonists)\n\nExclusion Criteria:\n\n* Other severe cardiopulmonary disease\n* Inability to perform ECT or CLE test\n* Inability to perform technically acceptable spirometry\n* Asthma exacerbation or respiratory tract infection in the last 2 weeks\n* Short-acting β2-agonists or long-acting β2-agonists use less than respectively 8 and 24 hours before the ECT or CLE test\n* Oral corticosteroid use in the 4 weeks before the ECT or CLE test","ALL","12 Years","18 Years",{"count":54,"type":55},200,"ESTIMATED","INTERVENTIONAL",[58],"NA","The goal of this cross-sectional study is to investigate the prevalence of Exercise Induced Laryngeal Obstruction (EILO) in children with asthma.\n\nThe hypothesis is that the prevalence will be around 15%, which is higher than the prevalence of 5-8% among the general adolescent population. This is based on the increased prevalence of EILO among adult asthmatics.\n\nParticipants who are referred for an Exercise Challenge Test will perform an additional Continuous Laryngoscopy during Exercise Test with expiratory FEV1 curves, and fill in the Borg scale for dyspnea, Asthma Control Test, EILODI questionnaire and DISCO-RC questionnaire.",[61,62,63,64,65,66],"Exercise Induced Laryngeal Obstruction","Asthma in Children","Exercise-Induced Bronchospasm","Exercise-Induced Bronchoconstriction","Dyspnea","Larynx","NOT_YET_RECRUITING","2024-06-26",{"date":70,"type":71},"2024-06-28","ACTUAL",{"date":73,"type":55},"2024-08-01",{"date":75,"type":55},"2026-04-30",{"name":5,"class":6},1]