[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595487":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":45,"centralContacts":50,"locations":56,"responsibleParty":132,"collaborators":134,"id":137,"slug":138,"hasResults":139,"nctId":140,"briefTitle":141,"officialTitle":141,"acronym":28,"eligibilityCriteria":142,"healthyVolunteers":143,"sex":144,"minAge":145,"maxAge":28,"enrollmentInfo":146,"targetDuration":28,"studyType":149,"phases":150,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":73,"whyStopped":28,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":168},{"fullName":5,"class":6},"The Institute of Molecular and Translational Medicine, Czech Republic","OTHER",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm A","EXPERIMENTAL","Participants over 40 years attending cooperating dental clinics, who agree to the study, complete questionnaire and provide self-sampled gargling sample. These will be tested by CE-IVD-marked HPV diagnostic test. This arm will include approx. 10000 participants.",[13,14,15,16],"Diagnostic Test: Self-sampling by gargling kit at dental clinic","Other: Questionnaire","Diagnostic Test: Blood sampling","Diagnostic Test: Self-sampling of the urogenital area",{"label":18,"type":10,"description":19,"interventionNames":20},"Arm B","Participants over 40 years selected from available databases receive by mail the study information, questionnaire and self-sampling gargling kit. The kits will be sent back to laboratory and will be tested by CE-IVD-marked HPV diagnostic test. This arm will include approx. 10000 participants.",[14,21,15,16],"Diagnostic Test: Self-sampling by gargling kit at home",[23,29,33,37,41],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DIAGNOSTIC_TEST","Self-sampling by gargling kit at dental clinic","Participants will perform a self-sampling at the dental clinic using gargling kit",[9],null,{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":28},"Questionnaire","Participants will answer questionnaire online\u002Fpaper at their home or at the dental clinic",[9,18],{"type":24,"name":34,"description":35,"armGroupLabels":36,"otherNames":28},"Self-sampling by gargling kit at home","Participants will perform a self-sampling at home using gargling kit",[18],{"type":24,"name":38,"description":39,"armGroupLabels":40,"otherNames":28},"Blood sampling","Venous blood will be collected from study participants with oral hrHPV positivity, in which the presence of circulating hrHPV DNA will be determined.",[9,18],{"type":24,"name":42,"description":43,"armGroupLabels":44,"otherNames":28},"Self-sampling of the urogenital area","In case of a positive examination in the oropharynx, the tested individuals will be offered a self-collection HPV examination in the urogenital area (cervicovaginal swab in women or external genital swab in men).",[9,18],[46],{"name":47,"affiliation":48,"role":49},"Marian Hajduch, Ph.D.","Faculty of Medicine and Dentistry, Palacky University, Olomouc","STUDY_DIRECTOR",[51],{"name":52,"role":53,"phone":54,"phoneExt":28,"email":55},"Vladimira Koudelakova, Ph.D.","CONTACT","+420585632089","vladimira.koudelakova@upol.cz",[57,71,85,100,115],{"facility":58,"status":59,"city":60,"state":28,"zip":28,"country":61,"countryCode":28,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Masaryk Memorial Cancer Institute","NOT_YET_RECRUITING","Brno","Czechia",{"type":63,"coordinates":64},"Point",[65,66],16.60796,49.19522,{"lat":66,"lon":65},[69],{"name":70,"role":53,"phone":28,"phoneExt":28,"email":28},"Jana Halamaková, MD.",{"facility":72,"status":73,"city":60,"state":28,"zip":28,"country":61,"countryCode":28,"cosmosGeoPoint":74,"geoPoint":76,"contacts":77},"Stomatologická klinika, Fakultní nemocnice u sv. Anny","RECRUITING",{"type":63,"coordinates":75},[65,66],{"lat":66,"lon":65},[78,82],{"name":79,"role":53,"phone":80,"phoneExt":28,"email":81},"Lydie Izakovičová Hollá, MD, PhD.","+420 543 183 412","sekr.stk@fnusa.cz",{"name":83,"role":84,"phone":28,"phoneExt":28,"email":28},"Lydie Izakovičová Hollá, MD","PRINCIPAL_INVESTIGATOR",{"facility":86,"status":73,"city":87,"state":28,"zip":88,"country":61,"countryCode":28,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Stomatologické centrum ARTDENT s.r.o.","Jihlava","586 01",{"type":63,"coordinates":90},[91,92],15.59124,49.3961,{"lat":92,"lon":91},[95,99],{"name":96,"role":53,"phone":97,"phoneExt":28,"email":98},"Jana Vrbková, MD","+420 567 331 666","recepce@artdent.eu",{"name":96,"role":84,"phone":28,"phoneExt":28,"email":28},{"facility":101,"status":73,"city":102,"state":28,"zip":103,"country":61,"countryCode":28,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"Klinika zubního lékařství Fakultní nemocnice Olomouc","Olomouc","77900",{"type":63,"coordinates":105},[106,107],17.25175,49.59552,{"lat":107,"lon":106},[110,114],{"name":111,"role":53,"phone":112,"phoneExt":28,"email":113},"Iva Voborná, MD","+420585859229","iva.voborna@fnol.cz",{"name":111,"role":84,"phone":28,"phoneExt":28,"email":28},{"facility":116,"status":73,"city":117,"state":28,"zip":118,"country":61,"countryCode":28,"cosmosGeoPoint":119,"geoPoint":123,"contacts":124},"CLINIQ Dejvice","Prague","160 00",{"type":63,"coordinates":120},[121,122],14.42076,50.08804,{"lat":122,"lon":121},[125,129,131],{"name":126,"role":53,"phone":127,"phoneExt":28,"email":128},"Valerie Burešová, Mgr.","+420 731 705 707","recepce@cliniqdejvice.cz",{"name":130,"role":53,"phone":127,"phoneExt":28,"email":128},"Jakub Studený, MDDr.",{"name":130,"role":84,"phone":28,"phoneExt":28,"email":28},{"type":133,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR",[135],{"name":136,"class":6},"National Institute for Cancer Research, Czech Republic","100595487","prevalence-of-human-papillomavirus-hpv-in-a-healthy-population-a-feasibility-study-of-oropharyngeal-cancer-screening-100595487",false,"NCT07033091","Prevalence of Human Papillomavirus (HPV) in a Healthy Population: A Feasibility Study of Oropharyngeal Cancer Screening","Inclusion Criteria:\n\n* Participants aged 40 years or older at the time of enrollment.\n* Individuals who are capable of rinsing the oral cavity by gargling independently.\n* Signed informed consent for study participation, molecular-genetic testing, and personal data processing.\n\nExclusion Criteria:\n\n\\- Previously diagnosed head and neck cancer.",true,"ALL","40 Years",{"count":147,"type":148},20000,"ESTIMATED","INTERVENTIONAL",[151],"NA","This study defines the prevalence of oral infection with high-risk human papillomaviruses (hrHPV) in individuals over 40 years of age in the Czech Republic. It also establishes an effective methodology for oropharyngeal carcinoma screening and optimization of screening and testing procedures.",[154],"Oropharynx Cancer",[156,157,158],"Human Papillomavirus","HPV Infection","oropharyngeal cancer","2026-02-11",{"date":161,"type":162},"2026-02-13","ACTUAL",{"date":164,"type":162},"2025-06-01",{"date":166,"type":148},"2031-03-30",{"name":5,"class":6},5]