[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604052":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":27,"centralContacts":31,"locations":41,"responsibleParty":64,"collaborators":21,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":21,"maxAge":76,"enrollmentInfo":77,"targetDuration":21,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":89,"whyStopped":21,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"CHD patients","EXPERIMENTAL","A- Full History Taking:\n\nB- General Examination:\n\nC- Cardiac Examination:\n\n1. Physical examination\n2. Echocardiography\n\nD- Hepatic Examination:\n\n1. Physical examination\n2. Biochemical Markers: To assess hepatic function in congenital heart disease (CHD) patients, blood samples will be collected from all patients in our study\n3. Abdominal ultrasound:",[13,14],"Diagnostic Test: Ultrasonography","Procedure: Blood Sampling",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DIAGNOSTIC_TEST","Ultrasonography","Ultrasound, also known as sonography or ultrasonography, is a medical imaging technique that uses high-frequency sound waves to create real-time images of internal body structures",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"PROCEDURE","Blood Sampling","To assess hepatic function in congenital heart disease (CHD) patients, blood samples will be collected from all patients in our study for:\n\n* Alanine Transferase (ALT).\n* Aspartate Aminotransferase (AST).\n* Gamma Glutamyl Transferase (GGT).\n* Alkaline Phosphatase (ALP).\n* Total\u002Fdirect bilirubin.\n* Albumin.\n* Prothrombin time.\n* International Normalized Ratio (INR).\n* Platelet count.",[9],[28],{"name":29,"affiliation":5,"role":30},"Duaa Raafat, Professor","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":21,"email":36},"Yasmin Nassar, Doctor","CONTACT","01090356527","dr.yasminnassar@gmail.com",{"name":38,"role":34,"phone":39,"phoneExt":21,"email":40},"Ahmed Zuhry, Lecturer","01010168440","Ahmedzuhry3990@aun.edu.eg",[42],{"facility":43,"status":21,"city":44,"state":45,"zip":21,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Assiut University Children Hospital.","Asyut","Assiut City","Egypt","EG",{"type":49,"coordinates":50},"Point",[51,52],31.18368,27.18096,{"lat":52,"lon":51},[55,58,60,61,63],{"name":56,"role":34,"phone":57,"phoneExt":21,"email":36},"Yasmin Nassar, doctor","+201090356527",{"name":38,"role":34,"phone":59,"phoneExt":21,"email":40},"+201010168440",{"name":29,"role":30,"phone":21,"phoneExt":21,"email":21},{"name":33,"role":62,"phone":21,"phoneExt":21,"email":21},"SUB_INVESTIGATOR",{"name":38,"role":62,"phone":21,"phoneExt":21,"email":21},{"type":30,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"Yasmin Nassar Mohamed Ahmed","Lecturer","100604052","prevalence-of-liver-dysfunction-in-pediatric-patients-with-congenital-heart-disease-at-assiut-100604052",false,"NCT07144501","Prevalence of Liver Dysfunction in Pediatric Patients With Congenital Heart Disease at Assiut.","Prevalence of Liver Dysfunction in Paediatric Patients With Congenital Heart Disease: A Cross-Sectional Study at Assiut University Children Hospital.","CHD","Inclusion Criteria:\n\n* Confirmed pediatric CHD patients attending Assiut University Children's Hospital.\n* Age: from birth up to 16 years old.\n\nExclusion Criteria:\n\n* Patients with primary liver disease.\n* Recent cardiac surgery (\\\u003C3 m) (to exclude acute postoperative liver injury).\n* Active systemic infection\u002Fsepsis (to avoid confounding liver enzyme elevations).","ALL","16 Years",{"count":78,"type":79},40,"ESTIMATED","INTERVENTIONAL",[82],"NA","Liver dysfunction is a well-documented complication in patients with congenital heart disease (CHD). The mechanisms leading to hepatic dysfunction may be multifactorial. Key risk factors for liver dysfunction in CHD include prolonged hypoxemia, high venous pressure, and prolonged duration of heart disease.\n\nWhile global studies have extensively explored this association, the prevalence of liver dysfunction in CHD varies, with studies reporting hepatic fibrosis in 30-40% of Fontan patients, while regional data, particularly from Egypt, remain limited.\n\nIn this research we aim to determine the prevalence of biochemical and radiological hepatic abnormalities in pediatric CHD patients attending Assiut University Children's Hospital.",[85,86],"Congenital Heart Disease","Liver Dysfunction",[73,88],"Liver dysfunction","NOT_YET_RECRUITING","2025-08-25",{"date":92,"type":93},"2025-08-27","ACTUAL",{"date":95,"type":79},"2025-09-15",{"date":97,"type":79},"2026-03-15",{"name":5,"class":6},1]