[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606408":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":10,"responsibleParty":29,"collaborators":10,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":39,"eligibilityCriteria":40,"healthyVolunteers":35,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":10,"studyType":47,"phases":10,"briefSummary":48,"conditions":49,"keywords":52,"overallStatus":57,"whyStopped":10,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Children with Down Syndrome",null,"Children (0-18 years) with cytogenetically confirmed Down syndrome, recruited from Assiut University Children's Hospital and Health Insurance Hospital. All participants will undergo full clinical assessment and karyotyping.",[13],"Other: No medical or experimental intervention will be administered",{"label":15,"type":10,"description":16,"interventionNames":17},"Parents of Children with Down Syndrome","Available biological parents of enrolled children will undergo chromosomal analysis (karyotyping) to determine balanced translocation carrier status.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"No medical or experimental intervention will be administered","Laboratory procedures (blood sampling for karyotyping, basic investigations such as echocardiography, thyroid function tests, abdominal ultrasound) are part of standard diagnostic assessment, not rese",[9,15],[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"fady bassim fathy, resident","CONTACT","01223011968","bassimfady@gmail.com",{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Fady Bassem","resident","100606408","prevalence-of-translocation-phenotyping-in-children-with-down-syndrome-and-their-parents-100606408",false,"NCT07175168","Prevalence of Translocation Phenotyping in Children With Down Syndrome and Their Parents","Prevalence of Translocation Phenotyping in Children With Down Syndrome and Their Parents: A Cross-Sectional Study","PTP-DS","Inclusion Criteria:\n\n* Children aged 0-18 years with confirmed diagnosis of Down syndrome by chromosomal analysis.\n\nAvailability of at least one biological parent willing to undergo chromosomal analysis.\n\nExclusion Criteria:\n\n* Children with Down syndrome due to free trisomy 21 or mosaicism.\n\nIncomplete parental data or refusal of parental participation.","ALL","1 Year","18 Years",{"count":45,"type":46},230,"ESTIMATED","OBSERVATIONAL","This research study will investigate a special type of Down syndrome called translocation Down syndrome. While most children with Down syndrome have an extra copy of chromosome 21, about 3-4% have this extra chromosome material attached to another chromosome, known as a translocation. This form can sometimes be inherited from a parent who carries a balanced translocation.\n\nThe aim of the study is to find out how common translocation Down syndrome is among children with confirmed Down syndrome in Assiut, Egypt, and to check whether their parents are carriers of a balanced translocation. Understanding this will help improve family counseling, estimate the chance of recurrence in future pregnancies, and guide genetic screening and prevention strategies.",[50,51],"Translocation Down Syndrome","Chromosomal Abnormalities",[53,54,55,56],"Balanced translocation","trisomy 21","Translocation","Down syndrome","NOT_YET_RECRUITING","2025-09-09",{"date":60,"type":61},"2025-09-16","ACTUAL",{"date":63,"type":46},"2025-10-01",{"date":65,"type":46},"2026-12-01",{"name":5,"class":6}]