[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622341":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":29,"locations":35,"responsibleParty":86,"collaborators":10,"id":88,"slug":89,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":10,"eligibilityCriteria":94,"healthyVolunteers":90,"sex":95,"minAge":96,"maxAge":10,"enrollmentInfo":97,"targetDuration":100,"studyType":101,"phases":10,"briefSummary":102,"conditions":103,"keywords":10,"overallStatus":105,"whyStopped":10,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"China National Center for Cardiovascular Diseases","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Valve surgery with concomitant LAA suture closure",null,"Concomitant suture closure of the LAA performed during surgical valve surgery.",[13],"Procedure: Left Atrial Appendage (LAA) Suture Closure",{"label":15,"type":10,"description":16,"interventionNames":17},"Valve surgery alone (no LAA procedure)","Standard surgical valve surgery without concomitant LAA suture closure.",[18],"Procedure: Surgical Valve Surgery",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Left Atrial Appendage (LAA) Suture Closure","Concomitant suture closure of the LAA performed at the time of surgical valve surgery, at the discretion of the operating surgeon.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Surgical Valve Surgery","Standard surgical valve repair or replacement performed according to routine clinical practice.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"LIANXIN Chen","CONTACT","01088322265","chenlianx1@163.com",[36,50,60,73],{"facility":37,"status":10,"city":38,"state":39,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Fuwai Hospital Chinese Academy of Medical Sciences","Beijing","Beijing Municipality","China","CN",{"type":43,"coordinates":44},"Point",[45,46],116.39723,39.9075,{"lat":46,"lon":45},[49],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"facility":51,"status":10,"city":38,"state":39,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":52,"geoPoint":54,"contacts":55},"Peking University First Hospita",{"type":43,"coordinates":53},[45,46],{"lat":46,"lon":45},[56],{"name":57,"role":32,"phone":58,"phoneExt":10,"email":59},"Wang","13522784537","wj0463@sina.cn",{"facility":61,"status":10,"city":62,"state":10,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Qingdao Cardiovascular Hospital","Qingdao",{"type":43,"coordinates":64},[65,66],120.38042,36.06488,{"lat":66,"lon":65},[69],{"name":70,"role":32,"phone":71,"phoneExt":10,"email":72},"Feng","13964265680","fengzunyi@163.com",{"facility":74,"status":10,"city":75,"state":10,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen","Shenzhen",{"type":43,"coordinates":77},[78,79],114.0683,22.54554,{"lat":79,"lon":78},[82],{"name":83,"role":32,"phone":84,"phoneExt":10,"email":85},"Nie","13701176101","wangsymd@126.com",{"type":87,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100622341","preventing-neurologic-complications-in-valve-surgery-100622341",false,"NCT07382362","Preventing Neurologic Complications in Valve Surgery","Strategies for the Prevention of Perioperative Neurological Complications in Cardiac Valve Surgery","Inclusion Criteria:\n\n* Adult patients (≥18 years) without atrial fibrillation who are scheduled to undergo open (direct-vision) surgical heart valve surgery and who are informed about the study and provide written informed consent to participate.\n\nExclusion Criteria:\n\n* History of prior cardiac surgery\n* history of cerebral infarction (ischemic stroke)\n* emergency surgery\n* infective endocarditis\n* pregnancy\n* refusal or inability to provide informed consent\u002Fdeclines participation in this study.","ALL","18 Years",{"count":98,"type":99},100,"ESTIMATED","1 Year","OBSERVATIONAL","In patients with valvular heart disease and atrial fibrillation (AF) undergoing surgical valve surgery, current guidelines recommend concomitant surgical management of the left atrial appendage (LAA) to prevent postoperative thromboembolic events, particularly neurologic embolic events. However, whether concomitant LAA management benefits patients without AF by reducing postoperative neurologic complications remains controversial.\n\nGiven these uncertainties, this study aims to evaluate whether concomitant LAA suture closure during surgical valve surgery is associated with a lower incidence of perioperative silent cerebral infarction.",[104],"Left Atrial Appendage Closure","NOT_YET_RECRUITING","2026-01-25",{"date":108,"type":109},"2026-02-02","ACTUAL",{"date":111,"type":99},"2026-01-27",{"date":113,"type":99},"2028-07-31",{"name":5,"class":6},4]