[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632958":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":31,"locations":45,"responsibleParty":57,"collaborators":31,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":31,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":31,"overallStatus":83,"whyStopped":31,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Universidad Nacional de Caaguazu","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Prison 1. Intensive intervention. Mass screening twice a year and massive TPT.","ACTIVE_COMPARATOR","Arm 1. Prison One. This is the branch with the highest intervention intensity. Mass screenings for active and latent TB will be conducted at months 0, 6, 12, and 18. Mass TB testing will be performed on the entire prison population.",[13],"Diagnostic Test: Type 1 - Intensive Intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"Prison 2. Optimized intervention. Mass screening twice a year and TPT to specific cases","This is the \"optimized\" intervention arm. Mass screening for active and latent TB will be conducted at months 0, 6, 12, and 18. The TPT test will only be performed on cases of latent TB infection in HIV-positive individuals and other immunocompromised patients.",[18],"Diagnostic Test: Type 2 - Optimized intervention",{"label":20,"type":21,"description":22,"interventionNames":23},"Prison 3. Control intervention. Mass screening once a year and TPT to specific cases","SHAM_COMPARATOR","This is the \"control\" intervention arm. Mass screenings for active and latent TB will be conducted at month 0 and 12 months. The TB test will only be performed on cases of latent infection in HIV-positive individuals and other immunocompromised patients. It is the usual NTP intervention.",[24],"Diagnostic Test: Type 3. Control.",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DIAGNOSTIC_TEST","Type 1 - Intensive Intervention","Type 1. This is the branch with the highest intervention intensity. Mass screenings for active and latent TB will be conducted at months 0, 6, 12, and 18. Mass TB testing will be performed on the entire prison population.",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Type 2 - Optimized intervention","Type 2. This is the intervention with mass screenings for active and latent tuberculosis that will be carried out in months 0, 6, 12 and 18. TPT treatment will only be given to groups of people with HIV+ and other immunocompromised individuals.",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Type 3. Control.","Type 3. This intervention involves mass screening for active and latent tuberculosis, to be conducted in months 0 and 12. TPT treatment will be administered only to HIV-positive and other immunocompromised individuals. This intervention is similar to that of the NTP.",[20],[41],{"name":42,"affiliation":43,"role":44},"Guillermo Sequera, PhD, MD","Universidad Nacional de Caaguazú","PRINCIPAL_INVESTIGATOR",[46],{"facility":43,"status":31,"city":47,"state":48,"zip":31,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":31},"Coronel Oviedo","Caaguazú Department","Paraguay","PY",{"type":52,"coordinates":53},"Point",[54,55],-56.43928,-25.44613,{"lat":55,"lon":54},{"type":44,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Guillermo Sequera","PhD, MD, Caaguazú National University","100632958","prevention-and-mass-screening-of-tb-in-prisons-in-paraguay-100632958",false,"NCT07520448","Prevention and Mass Screening of TB in Prisons in Paraguay","Prevention and Mass Screening of TB in Prisons in Paraguay (PRESMAP-TB)","PRESMAP-TB","Inclusion Criteria:\n\n1. Be a person deprived of liberty (PDL) residing in one of the participating penitentiary centers during the study period.\n2. Be 18 years of age or older at the time of enrollment.\n3. Be present in the penitentiary facility at the time of a screening round or enter the facility during the study period.\n4. Provide informed consent to participate in the study.\n\nExclusion Criteria:\n\n1. Are currently undergoing treatment for active tuberculosis at the time of the screening round.\n2. Have a medical condition that, in the opinion of the clinical staff, prevents the safe performance of the planned diagnostic procedures.","MALE","18 Years","65 Years",{"count":72,"type":73},4500,"ESTIMATED","INTERVENTIONAL",[76],"NA","The goal of this interventional study is to evaluate three tuberculosis (TB) screening and prevention strategies in prisons in Paraguay. The main questions it aims to answer are:\n\n* Which strategy is more effective for reducing the incidence rate of active TB?\n* Which strategy is more effective for reducing the TB infection rate?\n* Are these strategies safe, feasible, and cost-effective in prison settings?\n\nResearchers will compare three cluster-based, non-randomized programmatic strategies implemented in three prisons. These strategies differ in the frequency of screening, the diagnostic methods used, and the approach to tuberculosis preventive therapy (TPT).\n\nParticipants will:\n\n* undergo informed consent and clinical evaluation\n* receive TB screening through symptom assessment, chest digital X-ray with CAD, and rapid molecular testing, depending on site strategy\n* undergo IGRA testing and preventive therapy assessment, depending on the assigned strategy\n* be followed for 18 months, with screening rounds every 6 months or annually depending on the prison",[79,80,81,82],"Tuberculosis (TB)","TB Infection","Prisoners","Epidemiology","NOT_YET_RECRUITING","2026-04-08",{"date":86,"type":87},"2026-04-14","ACTUAL",{"date":89,"type":73},"2026-08-01",{"date":91,"type":73},"2028-12-31",{"name":5,"class":6},1]