[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580329":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":15,"locations":23,"responsibleParty":40,"collaborators":42,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":7,"enrollmentInfo":57,"targetDuration":7,"studyType":60,"phases":7,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":69,"whyStopped":7,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",null,[9,12],{"name":10,"affiliation":5,"role":11},"Joaquim MATEO, MD","STUDY_DIRECTOR",{"name":13,"affiliation":5,"role":14},"Fabrice VALLEE, MD PhD","PRINCIPAL_INVESTIGATOR",[16,20],{"name":10,"role":17,"phone":18,"phoneExt":7,"email":19},"CONTACT","+33(0)149958374","joaquim.mateo@aphp.fr",{"name":13,"role":17,"phone":21,"phoneExt":7,"email":22},"+33(0)149958071","fabrice.vallee@gmail.com",[24],{"facility":25,"status":7,"city":26,"state":7,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"AP-HP, Lariboisière Hospital, Department of Anesthesiology and Intensive Care","Paris","75010","France","FR",{"type":31,"coordinates":32},"Point",[33,34],2.3488,48.85341,{"lat":34,"lon":33},[37,39],{"name":10,"role":17,"phone":38,"phoneExt":7,"email":19},"33(0)149958374",{"name":13,"role":17,"phone":21,"phoneExt":7,"email":22},{"type":41,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[43,45],{"name":44,"class":6},"INSERM UMR-942, Paris, France",{"name":46,"class":6},"M3DISIM","100580329","prevention-of-lung-injury-induced-by-mechanical-ventilation-in-acute-respiratory-distress-syndrome-ards-patients-100580329",false,"NCT06835881","Prevention of Lung Injury Induced by Mechanical Ventilation in Acute Respiratory Distress Syndrome ARDS Patients","Exploratory Study on the Value of Advanced Respiratory Monitoring Data During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome (ARDS) in Terms of (1) Estimating the Risk of Ventilator Induced Lung Injury (VILI) and (2) the Relationship Between Aeration Benefit and Gas Exchange","PULMODEL","Inclusion Criteria:\n\n* Adults ≥ 18 years requiring intensive care hospitalization for moderate-to-severe ARDS defined by a PaO2\u002FFiO2 ratio \\\u003C 200 mmHg and benefiting from respiratory monitoring including esophageal pressure (EPP) and EIT.\n* Patient having been individually informed and not objecting to the re-use of his\u002Fher data for research purposes or, where applicable, trusted support person \u002F close relative \u002F parent of patient unable to express his\u002Fher wishes.\n\nExclusion Criteria:\n\n* Patient, or where applicable, trusted support person \u002F close relative \u002F parent of patient unable to express his\u002Fher wishes, opposed to the re-use of his\u002Fher data for research purposes.","ALL","18 Years",{"count":58,"type":59},30,"ESTIMATED","OBSERVATIONAL","Given the huge volume of mechanically ventilated patients at risk of ARDS, optimizing hematosis by limiting pulmonary and systemic aggression associated with artificial ventilation techniques is a key objective if we are to further improve the prognosis of ARDS.\n\nWith a view to improving cardiopulmonary monitoring in ARDS, modeling using digital twins individualized by nature should ultimately enrich the diagnostic approach by simplifying the technical set-up. Advances in modeling in terms of speed, rendering and results could be applied to personalized monitoring to find the right artificial ventilation setting for the right patient, at the right time.",[63],"Adult Respiratory Distress Syndrome",[65,66,67,68],"Ventilator optimization","Ventilator induced lung injury","Digital twin","Smart data","NOT_YET_RECRUITING","2025-04-22",{"date":72,"type":73},"2025-04-24","ACTUAL",{"date":75,"type":59},"2025-06",{"date":77,"type":59},"2027-07",{"name":5,"class":6},1]