[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100486788":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":23,"centralContacts":27,"locations":36,"responsibleParty":54,"collaborators":18,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":18,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":39,"whyStopped":18,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Pontificia Universidad Catolica de Chile","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Physical exercise and dietary intervention for NAFLD","EXPERIMENTAL","The exercise program will consist of muscular strength and aerobic exercises; additionally, each session will start and end with low intensity warm-up and cool down periods. The program will be divided in months. Months 1-2, twice a week directly-supervised exercises group sessions, and 1 telehealth session. Months 3-6, once a week directly-supervised group session and twice a week home-based telehealth. Months 7-12, Monthly telephone support. Months 12, 24 and 36, All participants (control and intervention arms) will receive a full evaluation. In the dietary intervention, investigators proposed a diet rich in anti-inflammatory components, legumes and in dietary fiber. The baseline evaluation of nutritional condition includes: anthropometry, bioimpedance analysis, hepatobiliary ultrasound, Fibroscan,blood lipids, and a battery of metabolic markers and a diet survey, Automated Self-Administered 24-hour Dietary Assessment Tool (ASA24). Both interventions are performed in parallel.",[13],"Other: Physical exercise and dietary intervention for NAFLD",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of care","NO_INTERVENTION","Participants in the control arm first have a baseline evaluation of the nutritional condition, with anthropometry evaluation, bioimpedance analysis, hepatobiliary ultrasound, Fibroscan, blood lipids, a battery of metabolic markers, and a diet survey, Automated Self-Administered 24-hour Dietary Assessment Tool (ASA24). After the evaluation period, participants received one counseling session, including written material, with advice to follow a healthy diet rich in fruits and vegetables, whole-grain foods, low in salt and sugars, and recommendations for an exercise plan of at least 30 minutes of aerobic exercise three times a week.",null,[20],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":18},"Investigators will assess the efficiency of the intervention by measuring adherence to physical exercise and nutritional diet.",[9],[24],{"name":25,"affiliation":5,"role":26},"Catterina Ferreccio, MD","PRINCIPAL_INVESTIGATOR",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":18,"email":32},"Laura A Huidobro, PhD","CONTACT","+56 9 9219 6618","leahuidobro@gmail.com",{"name":25,"role":30,"phone":34,"phoneExt":18,"email":35},"+56 9 95788658","catferre@gmail.com",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":18,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Centro MAUCO+","RECRUITING","Molina","Maule Region","Chile","CL",{"type":45,"coordinates":46},"Point",[47,48],-71.28232,-35.11428,{"lat":48,"lon":47},[51],{"name":52,"role":30,"phone":18,"phoneExt":18,"email":53},"Laura A Huidobro, MD, PhD","ahuidobro@ucm.cl",{"type":26,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Catterina Ferreccio","Principal Investigator","100486788","prevention-of-nafld-and-cvd-through-lifestyle-intervention-100486788",false,"NCT05618626","Prevention of NAFLD and CVD Through Lifestyle Intervention","Cardiovascular Diseases (CVD) and Nonalcoholic Fatty Liver Diseases (NAFLD) Among Gallstone and Cholecystectomy Patients and the Impact of a Novel Diet and Muscle Training Program","MAUCO+","Inclusion Criteria:\n\n* With and without gallstones disease\n* With various degrees of NAFLD (none too severe)\n\nExclusion Criteria:\n\n* Any significant comorbidity or physical limitation to undergo resistance exercise program\n* Use of medications that alter muscle mass (e.g., corticosteroids)\n* History of hepatitis B or C\n* Use of hepatotoxic drugs",true,"ALL","45 Years","60 Years",{"count":70,"type":71},300,"ESTIMATED","INTERVENTIONAL",[74],"NA","Prevention of non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) through lifestyle intervention (MAUCO+) is a clinical trial that aims to improve sarcopenia, aerobic capacity, body composition, and lipid profile, insulin resistance, cardiovascular risk, NAFLD, and maintain a healthier lifestyle. Through the implementation of physical activity and nutritional programs.",[77,78],"Non-Alcoholic Fatty Liver Disease","Gallstone Disease",[80,81,82],"Anti-inflammatory diet","Lifestyle modification","Physical Activity","2024-11-17",{"date":85,"type":86},"2024-11-19","ACTUAL",{"date":88,"type":86},"2021-09-27",{"date":90,"type":71},"2025-04-30",{"name":5,"class":6},1]