[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630243":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":17,"centralContacts":22,"locations":32,"responsibleParty":82,"collaborators":85,"id":119,"slug":120,"hasResults":121,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":127,"sex":128,"minAge":10,"maxAge":10,"enrollmentInfo":129,"targetDuration":132,"studyType":133,"phases":10,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":150},{"fullName":5,"class":6},"Copenhagen University Hospital at Herlev","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"First trimester screening for preeclampsia",null,[12],"Other: First trimester screening for preeclampsia",[14],{"type":6,"name":9,"description":15,"armGroupLabels":16,"otherNames":10},"Screening for preeclampsia using maternal factors, Mean arterial pressure, flow in the uterine arteries and Placental Growth Factor",[9],[18],{"name":19,"affiliation":20,"role":21},"Charlotte Kvist Ekelund, Consultant, ass. prof., MD","Rigshospitalet, Denmark","PRINCIPAL_INVESTIGATOR",[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Charlotte Kvist Ekelund, Consultant, ass. prof. PhD","CONTACT","+45 28265042","charlotte.kvist.ekelund@regionh.dk",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},"Iben Riishede, MD, PhD","+45 21701481","ichr0089@regionh.dk",[33,52,69],{"facility":34,"status":35,"city":36,"state":10,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Aarhus University","RECRUITING","Aarhus","8200","Denmark","DK",{"type":41,"coordinates":42},"Point",[43,44],10.21076,56.15674,{"lat":44,"lon":43},[47,49,50],{"name":48,"role":25,"phone":26,"phoneExt":10,"email":27},"Charlotte Kvist Ekelund, Consultant, Ass. prof., PhD",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},{"name":51,"role":21,"phone":10,"phoneExt":10,"email":10},"Puk Sandager, Consultant, MD",{"facility":53,"status":35,"city":54,"state":10,"zip":55,"country":38,"countryCode":39,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"University of Copenhagen","Copenhagen","2100",{"type":41,"coordinates":57},[58,59],12.56553,55.67594,{"lat":59,"lon":58},[62,63,64,67],{"name":48,"role":25,"phone":26,"phoneExt":10,"email":27},{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},{"name":65,"role":66,"phone":10,"phoneExt":10,"email":10},"Marie Helmbæk, MD","SUB_INVESTIGATOR",{"name":68,"role":21,"phone":10,"phoneExt":10,"email":10},"Charlotte Kvist Ekelund, Consultant, ass. prof., PhD",{"facility":53,"status":35,"city":70,"state":10,"zip":71,"country":38,"countryCode":39,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Hillerød","3400",{"type":41,"coordinates":73},[74,75],12.30081,55.92791,{"lat":75,"lon":74},[78,79,80],{"name":48,"role":25,"phone":26,"phoneExt":10,"email":27},{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},{"name":81,"role":21,"phone":10,"phoneExt":10,"email":10},"Anne Cathrine Roslev, Consultant",{"type":21,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":20,"oldNameTitle":10,"oldOrganization":10},"Iben Riishede","Principal Investigator",[86,88,90,92,94,96,98,100,102,105,107,109,111,113,115,117],{"name":87,"class":6},"Aarhus University Hospital Skejby",{"name":89,"class":6},"Odense University Hospital",{"name":91,"class":6},"Aalborg University Hospital",{"name":93,"class":6},"Copenhagen University Hospital, Hvidovre",{"name":95,"class":6},"Nordsjaellands Hospital",{"name":97,"class":6},"Slagelse Hospital",{"name":99,"class":6},"Holbaek Sygehus",{"name":101,"class":6},"Nykøbing Falster County Hospital",{"name":103,"class":104},"Bornholm Hospital, Denmark","UNKNOWN",{"name":106,"class":6},"Esbjerg Hospital - University Hospital of Southern Denmark",{"name":108,"class":6},"Zealand University Hospital",{"name":110,"class":104},"Lillebaelt Hospital, Kolding and Vejle, Denmark",{"name":112,"class":6},"Gødstrup Hospital",{"name":114,"class":6},"Viborg Regional Hospital",{"name":116,"class":6},"Horsens Hospital",{"name":118,"class":104},"Hospital of Southern Jutland, Aabenraa, Denmark","100630243","prevention-of-preeclampsia-in-denmark-a-national-implementation-study-100630243",false,"NCT07485140","Prevention of Preeclampsia in Denmark: A National Implementation Study","Prevention of Preeclampsia in Denmark (PREPRED): A National Implementation Study","PREPRED","Inclusion Criteria:\n\n* Pregnant women with a viable singleton pregnancy\n* Attendance at a routine first-trimester ultrasound scan at 11+0 to 13+6 weeks of gestation at a Danish maternity hospital during the study period\n* Valid Danish personal identification number (CPR number) enabling linkage with national health registries\n\nExclusion Criteria:\n\n* Multiple pregnancy (e.g., twins or higher-order gestations)\n* Major fetal anomaly diagnosed before completion of first-trimester screening\n* Miscarriage or pregnancy loss diagnosed before completion of first-trimester screening",true,"FEMALE",{"count":130,"type":131},80000,"ESTIMATED","6 Months","OBSERVATIONAL","The goal of this clinical study is to learn if a new first-trimester screening program can better find pregnant women who are at high risk of developing preeclampsia and help prevent the condition with early treatment.\n\nPreeclampsia is a pregnancy condition that causes high blood pressure and can affect the mother's organs and the baby's growth. Early detection allows doctors to offer preventive treatment, such as low-dose aspirin, which may lower the risk of serious illness.\n\nThe study includes pregnant women with a single pregnancy who attend their routine first-trimester scan at maternity hospitals in Denmark.\n\nThe main questions it aims to answer are:\n\nDoes the new screening program lower the number of women who develop preterm preeclampsia (preeclampsia before thirty-seven weeks of pregnancy)?\n\nCan the screening program be carried out safely and be acceptable for pregnant women and healthcare professionals?\n\nResearchers will gradually introduce the new screening program across hospitals and compare outcomes before and after the program starts. Women who are found to have a high risk of preeclampsia will be offered preventive treatment with low-dose aspirin.\n\nParticipants will:\n\nReceive information about preeclampsia and the screening during their first-trimester visit\n\nHave their blood pressure measured and an ultrasound assessment of blood flow to the uterus during the routine scan\n\nHave routine blood samples analysed to estimate their personal risk of preeclampsia\n\nBe offered daily low-dose aspirin until late pregnancy if they are identified as high risk\n\nContinue standard pregnancy care while researchers follow pregnancy outcomes using national health records\n\nThe study will help researchers understand whether this screening approach works in everyday care and whether it should become part of routine pregnancy care in Denmark.",[136],"Preeclampsia (PE)",[138,139,140],"Prevention","Screening","Preeclampsia","2026-03-16",{"date":143,"type":144},"2026-03-20","ACTUAL",{"date":146,"type":144},"2025-09-15",{"date":148,"type":131},"2027-11",{"name":5,"class":6},3]