[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644256":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":35,"locations":45,"responsibleParty":62,"collaborators":34,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":34,"enrollmentInfo":76,"targetDuration":34,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":93,"whyStopped":34,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Centre Hospitalier Universitaire Vaudois","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Scheduled group","EXPERIMENTAL","Oral morphine administered at predefined regular intervals starting immediately after surgery, with additional access to oral PCA.",[13],"Drug: Morphine provided via oral PCA + morphine administered at a scheduled regimen",{"label":15,"type":16,"description":17,"interventionNames":18},"On-demand group","ACTIVE_COMPARATOR","Oral morphine administered on demand via PCA.",[19],"Drug: Morphine provided via oral PCA",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Morphine provided via oral PCA","Morphine will be administered according to a scheduled regimen (20mg slow release oral morphine at fixed 12-hour intervals), with additional oral PCA on demand for breakthrough pain (VAS \\> 4), following the same bedside tablet procedure as in the control group. The maximum allowed dose through oral PCA will be 6 tablets (10mg each) per 24-hour period.",[15],[27],"Sevredol 10mg",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Morphine provided via oral PCA + morphine administered at a scheduled regimen","morphine will be administered according to a scheduled regimen (20mg slow-release oral morphine at fixed 12-hour intervals), with additional oral PCA on demand for breakthrough pain (VAS \\> 4), following the same bedside tablet procedure as in the control group. The maximum allowed dose through oral PCA will be 6 tablets (10mg each) per 24-hour period.",[9],[33],"Sevredol 10mg + slow-release oral morphine 20mg",null,[36,41],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},"Eric Albrecht, Prof.","CONTACT","+4179 556 63 41","eric.albrecht@chuv.ch",{"name":42,"role":38,"phone":43,"phoneExt":34,"email":44},"Iliana Mrazek","+4179 556 85 06","iliana.mrazek@chuv.ch",[46],{"facility":47,"status":34,"city":48,"state":34,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"CHUV, Centre Hospitalier Vaudois","Lausanne","1000","Switzerland","CH",{"type":53,"coordinates":54},"Point",[55,56],6.63282,46.516,{"lat":56,"lon":55},[59,61],{"name":60,"role":38,"phone":39,"phoneExt":34,"email":40},"Eric Albrecht, Prof",{"name":42,"role":38,"phone":43,"phoneExt":34,"email":44},{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","Eric Albrecht","Prof. Dr. Med. Eric Albrecht, Associate Professor, University of Lausanne","100644256","prevention-of-rebound-pain-after-orthopaedic-surgery-with-peripheral-nerve-block-reboundpart-a-100644256",false,"NCT07666971","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part A","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block: a Single-blinded Randomised Controlled Trial","REBOUND","Inclusion Criteria:\n\n* Patients scheduled for elective orthopaedic surgery on the upper limb\n* Patients scheduled for elective orthopaedic surgery on the lower limb.\n* Score ASA I-III; Patients aged over 18 years; Signed informed consent.\n* Surgery under general anaesthesia or under sedation\n\nExclusion Criteria:\n\n* Refusal or inability to understand the informed consent\n* Allergy to any of the following medications: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine,sufentanil, ondansetron, or dexamethasone\n* Patients with long term opioid treatment\n* Bleeding diathesis\n* Neurological disorders of the operated limb\n* Known renal insufficiency (eGFR \\\u003C30 mL\u002Fmin)\n* Known hepatic insufficiency (Child-Pugh class B or C);\n* Pregnant or breastfeeding women;\n* Alcohol dependence syndrome;\n* Patients under spinal anaesthesia;\n* Patients undergoing amputation procedures","ALL","18 Years",{"count":77,"type":78},100,"ESTIMATED","INTERVENTIONAL",[81],"NA","Rebound pain after peripheral nerve blocks reduces the benefits of regional anesthesia and increases opioid consumption. This rebound pain most likely results from suboptimal pain management, as patients receiving a peripheral nerve block are typically not given scheduled opioid doses. Oral Patient Controlled Analgesia (PCA) consists of an oral morphine prescription that allows patients to self-administer doses based on their pain score.\n\nThis study will compare patients undergoing elective orthopaedic surgery under general anaesthesia or sedation with a peripheral nerve block, receiving oral morphine PCA either with or without additional scheduled oral morphine doses.",[84,85,86],"Post Operative Analgesia","Rebound Pain","Post Operative Pain, Acute",[88,89,90,91,92],"rebound pain","postoperative pain","pain management","orthopaedic surgery","peripheral nerve block","NOT_YET_RECRUITING","2026-06-19",{"date":96,"type":97},"2026-06-24","ACTUAL",{"date":99,"type":78},"2026-06",{"date":101,"type":78},"2027-09",{"name":5,"class":6},1]