[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644261":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":58,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":26,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":89,"whyStopped":26,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Centre Hospitalier Universitaire Vaudois","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Scheduled group","EXPERIMENTAL","Oral morphine administered at predefined regular intervals starting immediately after surgery, with additional access to oral PCA.",[13],"Drug: Morphine provided via oral PCA + morphine administered at a scheduled regimen",{"label":15,"type":16,"description":17,"interventionNames":18},"On-demand group","ACTIVE_COMPARATOR","Oral morphine administered on demand via PCA.",[19],"Drug: Morphine provided via oral PCA",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Morphine provided via oral PCA","Morphine will be administered according to a scheduled regimen (20mg slow release oral morphine at fixed 12-hour intervals), with additional oral PCA on demand for breakthrough pain (VAS \\> 4), following the same bedside tablet procedure as in the control group. The maximum allowed dose through oral PCA will be 6 tablets (10mg each) per 24-hour period.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Morphine provided via oral PCA + morphine administered at a scheduled regimen","morphine will be administered according to a scheduled regimen (20mg slow-release oral morphine at fixed 12-hour intervals), with additional oral PCA on demand for breakthrough pain (VAS \\> 4), following the same bedside tablet procedure as in the control group. The maximum allowed dose through oral PCA will be 6 tablets (10mg each) per 24-hour period.",[9],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Eric Albrecht, Prof.","CONTACT","+41 79 556 63 41","eric.albrecht@chuv.ch",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Iliana Mrazek","+41 79 556 85 06","iliana.mrazek@chuv.ch",[42],{"facility":43,"status":26,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"CHUV, Centre Hospitalier Vaudois","Lausanne","Canton of Vaud","1000","Switzerland","CH",{"type":50,"coordinates":51},"Point",[52,53],6.63282,46.516,{"lat":53,"lon":52},[56,57],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Eric Albrecht","Prof. Dr. Med. Eric Albrecht, Associate Professor, University of Lausanne","100644261","prevention-of-rebound-pain-after-orthopaedic-surgery-with-peripheral-nerve-block-reboundpart-b-100644261",false,"NCT07666009","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part B","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block: a Single-blinded Randomised Controlled Trial","REBOUND","Inclusion Criteria:\n\n* Patients scheduled for elective orthopaedic surgery on the upper limb\n* Patients scheduled for elective orthopaedic surgery on the lower limb.\n* Score ASA I-III; Patients aged over 18 years; Signed informed consent.\n* Surgery under general anaesthesia or under sedation\n\nExclusion Criteria:\n\n* Refusal or inability to understand the informed consent\n* Allergy to any of the following medications: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine,sufentanil, ondansetron, or dexamethasone\n* Patients with long term opioid treatment\n* Bleeding diathesis\n* Neurological disorders of the operated limb\n* Known renal insufficiency (eGFR \\\u003C30 mL\u002Fmin)\n* Known hepatic insufficiency (Child-Pugh class B or C);\n* Pregnant or breastfeeding women;\n* Alcohol dependence syndrome;\n* Patients under spinal anaesthesia;\n* Patients undergoing amputation procedures","ALL","18 Years",{"count":73,"type":74},100,"ESTIMATED","INTERVENTIONAL",[77],"NA","Rebound pain after peripheral nerve blocks reduces the benefits of regional anesthesia and increases opioid consumption. This rebound pain most likely results from suboptimal pain management, as patients receiving a peripheral nerve block are typically not given scheduled opioid doses. Oral Patient Controlled Analgesia (PCA) consists of an oral morphine prescription that allows patients to self-administer doses based on their pain score.\n\nThis study will compare patients undergoing elective orthopaedic surgery under general anaesthesia or sedation with a peripheral nerve block, receiving oral morphine PCA either with or without additional scheduled oral morphine doses.",[80,81,82],"Post Operative Analgesia","Rebound Pain","Post Operative Pain, Acute",[84,85,86,87,88],"rebound pain","postoperative pain","pain management","orthopaedic surgery","peripheral nerve block","NOT_YET_RECRUITING","2026-06-18",{"date":92,"type":93},"2026-06-24","ACTUAL",{"date":95,"type":74},"2026-06",{"date":97,"type":74},"2027-09",{"name":5,"class":6},1]