[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636513":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":37,"locations":43,"responsibleParty":61,"collaborators":63,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":46,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Preventive Analgesia Group","EXPERIMENTAL","Patients in Preventive Analgesia Group will receive intravenous Anrikefon (1 μg\u002Fkg) at 15 minutes before anesthesia induction. Each bolus administration should be completed within 2 minutes ± 5 seconds.",[13],"Drug: Anrikefon for Preventive Analgesia",{"label":15,"type":16,"description":17,"interventionNames":18},"Bridging Analgesia Group","ACTIVE_COMPARATOR","Patients in Bridging Analgesia Group will receive intravenous Anrikefon (1 μg\u002Fkg) immediately after the gallbladder is dissected from the liver bed. Each bolus administration should be completed within 2 minutes ± 5 seconds.",[19],"Drug: Anrikefon for bridging analgesia",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Anrikefon for Preventive Analgesia","The Preventive Analgesia Group will receive intravenous Anrikefon (1 μg\u002Fkg) 15 minutes before anesthesia induction. Each bolus administration should be completed within 2 minutes ± 5 seconds.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Anrikefon for bridging analgesia","The Bridging Analgesia Group will receive intravenous Anrikefon (1 μg\u002Fkg) immediately after the gallbladder is removed from the liver bed. Each bolus administration should be completed within 2 minutes ± 5 seconds.",[15],[32,35],{"name":33,"affiliation":5,"role":34},"Wei Xiao","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":34},"Tianlong Wang",[38],{"name":39,"role":40,"phone":41,"phoneExt":26,"email":42},"Wei Xiao, PhD","CONTACT","+8613810971299","kitten15@126.com",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Xuanwu Hospital, Capital Medical University","RECRUITING","Beijing","Beijing Municipality","100053","China","CN",{"type":53,"coordinates":54},"Point",[55,56],116.39723,39.9075,{"lat":56,"lon":55},[59],{"name":33,"role":40,"phone":60,"phoneExt":26,"email":42},"8613810971299",{"type":62,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[64],{"name":65,"class":66},"Haisco Pharmaceutical Group Co., Ltd.","INDUSTRY","100636513","preventive-analgesia-with-anrikefon-in-laparoscopic-cholecystectomy-100636513",false,"NCT07566663","Preventive Analgesia With Anrikefon in Laparoscopic Cholecystectomy","Effect of Preventive Analgesia With Anrikefon on Postoperative Acute Pain and Rehabilitation Process in Adult Patients Undergoing Laparoscopic Cholecystectomy","ANIPAP","Inclusion Criteria:\n\n1. ASA physical status classification I-III;\n2. Age 18-65 years;\n3. Scheduled for elective laparoscopic cholecystectomy;\n4. Voluntary signed informed consent;\n5. BMI between 18-28 kg\u002Fm²;\n6. No history of general anesthesia surgery within the past 3 months.\n\nExclusion Criteria:\n\n1. Severe cardiovascular disease, respiratory disease, or psychiatric disorders;\n2. Severe renal insufficiency;\n3. Recent use of diuretics or compound medications containing diuretics;\n4. Continuous use of opioid analgesics for more than 10 days within the past 3 months;\n5. Use of medications with unknown half-life affecting analgesic efficacy within 14 days prior to randomization;\n6. Pregnant women, lactating women, or those planning pregnancy in the near future;\n7. History of hypersensitivity to study medications.","ALL","18 Years","65 Years",{"count":79,"type":80},274,"ESTIMATED","INTERVENTIONAL",[83],"NA","This study will determine the optimal timing for Anrikefon administration. It will also assess the quality of patient recovery. Laparoscopic cholecystectomy (LC) is a routine surgical procedure. However, the incidence of acute visceral and incision pain is high, reaching 50% to 70%. This pain significantly impairs patient recovery.\n\nAnrikefon is novel peripherally restricted κ-opioid receptor agonist. It has very low brain penetration. This property reduces central nervous system side effects and respiratory depression. Preventive analgesia blocks the transmission of nociceptive stimuli to the central nervous system. It reduces postoperative pain sensitization and intensity. Currently, research on Anrikefon for preventive analgesia in LC patients is limited. It impacts on the recovery process is not yet fully understood. This study will compare drug administration before anesthesia induction with intra-operative administration.\n\nParticipants will be assigned to one of two groups with equal probability using computer-generated random numbers. Patients in the Preventive Analgesia group will receive Anrikefon injection 15 minutes before anesthesia induction. Bridging Analgesia group is the control group. Patients in this group will receive Anrikefon immediately after the gallbladder is detached from the liver. Both groups will receive the identical drug dosage of 1 μg\u002Fkg.\n\nBoth treatment groups will receive identical care beyond the time of Anrikefon administration. All patients will undergo standardized anesthesia management. Parecoxib sodium 40 mg will be injected for rescue analgesia if NRS score \\> 4. We will analyze the primary, secondary, and exploratory outcome measures after surgery, aiming to explore the optimal timing of Anrikefon and its impact on the patient's recovery process.",[86],"Postoperative Pain",[88,89,90,91,92],"Preventive Analgesia","Laparoscopic Cholecystectomy","Postoperative Acute Pain","Visceral Pain","Anrikefon","2026-06-29",{"date":95,"type":96},"2026-07-01","ACTUAL",{"date":98,"type":96},"2026-06-02",{"date":100,"type":80},"2028-06-30",{"name":5,"class":6},1]