[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100484236":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":41,"responsibleParty":135,"collaborators":26,"id":137,"slug":138,"hasResults":139,"nctId":140,"briefTitle":141,"officialTitle":141,"acronym":26,"eligibilityCriteria":142,"healthyVolunteers":139,"sex":143,"minAge":144,"maxAge":26,"enrollmentInfo":145,"targetDuration":26,"studyType":148,"phases":149,"briefSummary":151,"conditions":152,"keywords":156,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":170},{"fullName":5,"class":6},"Yonsei University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"LBBAP group","EXPERIMENTAL","In this arm, a left bundle branch area pacing(LBBAP) lead will be attempted to be placed.",[13],"Procedure: Left bundle branch area pacing",{"label":15,"type":16,"description":17,"interventionNames":18},"RVP group","ACTIVE_COMPARATOR","In this arm, a Right ventricular pacing (RVP) lead will be attempted to be placed.",[19],"Procedure: Right ventricular pacing",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Left bundle branch area pacing","LBBAP success is defined if ventricular lead is successfully placed at interventricular septum and RBB configuration observed during unipolar tip pacing.\n\nLBB capture is defined if fulfilling criterion 1 and at least one in criteria 2.\n\n1. RBBB configuration observed during unipolar tip pacing\n2. One of the following should be met:\n\n   1. Abrupt shortening of Stim-LVAT (stimulus to peak of the R wave in V6 \\[LV activation time\\]) of \\>10ms during increasing output\n   2. Short and constant stim-LVAT and the shortest stim-LVAT \\\u003C75ms in non-LBBB and \\\u003C85ms in LBBB\n   3. Programmed stimulation by pacing lead changes QRS morphology from nonselective LBB to LV septal capture\n   4. LBB potential (LBB-V interval of 15 to 35ms)\n   5. Transition from nonselective LBB capture to selective LBB capture at near threshold outputs\n\nIf criterion 1 is fulfilled but none in criteria 2 is met, the procedure is considered to be deep septal pacing (DSP).",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Right ventricular pacing","Right ventricular pacing is the traditional pacing modality for ventricular pacing. Implantation of a RV pacing lead (apex or septum of right ventricle) will be attempted using the standard-of-care technique first",[15],[32],{"name":33,"affiliation":34,"role":35},"TaeHoon Kim","Severance Cardiovascular Hospital Yonsei University","PRINCIPAL_INVESTIGATOR",[37],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","+82 02-2228-8467","thkimcardio@yuhs.ac",[42,58,71,84,97,107,117,127],{"facility":43,"status":44,"city":45,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Bucheon Sejong Hospital","RECRUITING","Bucheon-si","South Korea",{"type":48,"coordinates":49},"Point",[50,51],126.78306,37.49889,{"lat":51,"lon":50},[54],{"name":55,"role":38,"phone":56,"phoneExt":26,"email":57},"Sang-Weon Park","032-340-1694","swparkmd@gmail.com",{"facility":59,"status":44,"city":60,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"GyeongSang National University Changwon Hospital","Changwon",{"type":48,"coordinates":62},[63,64],128.68111,35.22806,{"lat":64,"lon":63},[67],{"name":68,"role":38,"phone":69,"phoneExt":26,"email":70},"Ga-In Yu","010-4409-0602","yugainb@gmail.com",{"facility":72,"status":44,"city":73,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Chungbuk National University Hospital","Chungju",{"type":48,"coordinates":75},[76,77],127.9287,36.97666,{"lat":77,"lon":76},[80],{"name":81,"role":38,"phone":82,"phoneExt":26,"email":83},"Min Kim","043-269-6707","pupets01@gmail.com",{"facility":85,"status":44,"city":86,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Asan Medical Center","Seoul",{"type":48,"coordinates":88},[89,90],126.9784,37.566,{"lat":90,"lon":89},[93],{"name":94,"role":38,"phone":95,"phoneExt":26,"email":96},"Min-Soo Cho","02-3010-1327","d070294@gmail.com",{"facility":98,"status":44,"city":86,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":99,"geoPoint":101,"contacts":102},"Kyunghee University hospital",{"type":48,"coordinates":100},[89,90],{"lat":90,"lon":89},[103],{"name":104,"role":38,"phone":105,"phoneExt":26,"email":106},"Jin-Bae Kim","010-9996-6930","jinbbai@khu.ac.kr",{"facility":108,"status":44,"city":86,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":109,"geoPoint":111,"contacts":112},"Seoul National University Hospital",{"type":48,"coordinates":110},[89,90],{"lat":90,"lon":89},[113],{"name":114,"role":38,"phone":115,"phoneExt":26,"email":116},"Eue-Keun Choi","02-2072-2228","choiek417@gmail.com",{"facility":118,"status":44,"city":86,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":119,"geoPoint":121,"contacts":122},"Seoul Saint Mary's Hospital",{"type":48,"coordinates":120},[89,90],{"lat":90,"lon":89},[123],{"name":124,"role":38,"phone":125,"phoneExt":26,"email":126},"Young Choi","010-2214-2694","superstar@catholic.ac.kr",{"facility":128,"status":129,"city":86,"state":26,"zip":26,"country":46,"countryCode":26,"cosmosGeoPoint":130,"geoPoint":132,"contacts":133},"Yonsei University Health System, Severance Hospital","NOT_YET_RECRUITING",{"type":48,"coordinates":131},[89,90],{"lat":90,"lon":89},[134],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},{"type":136,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100484236","preventive-effect-of-left-bundle-branch-area-pacing-versus-right-ventricular-pacing-on-all-cause-death-heart-failure-progression-and-ventricular-dyssynchrony-in-patients-with-substantial-ventricular-pacing-protect-sync-multicenter-prospective-randomized-controlled-trial-100484236",false,"NCT05585411","PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n1. At least 19 years old and willing and capable to give informed consent\n2. Patients who is willing and able to comply with the prescribed follow-up tests and schedule of evaluations.\n\n3 Scheduled to receive a pacemaker implant 4. Substantial percentage of V pacing rate (\\>40%) is anticipated\n\nExclusion criteria:\n\n1. Incapacitated or unable to read or write\n2. Patient who is an indication of ICD or CRT\n3. History of prosthetic valve surgery on tricuspid valve\n4. Prior myocardial infarction including ventricular septum\n5. Life expectancy \\\u003C 12 months due to any condition\n6. Unavailable for at least 24 months of follow-up visits\n7. Pregnant or breastfeeding at the time of signing consent\n8. Prior Heart transplant surgery\n9. Persistent Left Superior Vena Cava (PLSVC)","ALL","19 Years",{"count":146,"type":147},450,"ESTIMATED","INTERVENTIONAL",[150],"NA","PROTECT-SYNC study is a multicenter, randomized, controlled trial. A total of 7 medical centers across Republic of Korea will enroll 450 patients during 2 years of enrollment period, and followed for 2 years of follow-up period. The purpose of this study to compare the clinical outcomes of Left Bundle Branch Area Pacing (LBBAP) compared to Right Ventricular Pacing (RVP) in bradyarrhythmia patients who require high burden of ventricular pacing (\\>40%).",[153,154,155],"Bradyarrhythmia","Atrioventricular Block","Left Bundle Branch Area Pacing",[157,158,159,160],"Left Bundle Branch Area pacing","Right Ventricular Pacing","Heart Failure","Atrioventricular block","2025-12-30",{"date":163,"type":164},"2026-01-05","ACTUAL",{"date":166,"type":164},"2022-11-01",{"date":168,"type":147},"2026-11-01",{"name":5,"class":6},8]