[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100443301":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":57,"collaborators":39,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":39,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":39,"enrollmentInfo":68,"targetDuration":39,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":43,"whyStopped":39,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Peking Union Medical College Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Preventive use of advanced antibiotics group","EXPERIMENTAL","Treat patients in this group with advanced preventive usage of antibiocs: Sulperazon 3g q8h, in postoperative days 1-5.",[13],"Drug: Preventive use of advanced antibiotics",{"label":15,"type":6,"description":16,"interventionNames":17},"Routine group","Treat patients in this group with routine preventive usage of antibiocs: Cefmetazole 1g q12h, in postoperative days 1-3.",[18],"Other: Routine",[20,26],{"type":21,"name":22,"description":11,"armGroupLabels":23,"otherNames":24},"DRUG","Preventive use of advanced antibiotics",[9],[25],"Sulperazon",{"type":6,"name":27,"description":16,"armGroupLabels":28,"otherNames":29},"Routine",[15],[30],"Cefmetazole",[32],{"name":33,"affiliation":5,"role":34},"Yatong Li, MD","STUDY_DIRECTOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":39,"email":40},"CONTACT","861069158547",null,"yatongli@qq.com",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Beijing","Beijing Municipality","100730","China","CN",{"type":50,"coordinates":51},"Point",[52,53],116.39723,39.9075,{"lat":53,"lon":52},[56],{"name":33,"role":37,"phone":38,"phoneExt":39,"email":40},{"type":58,"investigatorFullName":39,"investigatorTitle":39,"investigatorAffiliation":39,"oldNameTitle":39,"oldOrganization":39},"SPONSOR","100443301","preventive-therapy-of-postoperative-intra-abdominal-infection-based-on-serum-lactate-changes-100443301",false,"NCT05052619","Preventive Therapy of Postoperative Intra-abdominal Infection Based on Serum Lactate Changes","A Prospective, Randomized Clinical Trial to Treat Intra-abdominal Infection Preventively After Pancreatic Surgery Based on Serum Lactate Changes","Inclusion Criteria:\n\n1. treatment by pancreatic resection, including pancreaticoduodenectomy, pancreatosplenectomy, total pancreatectomy, and other variant operations;\n2. revival in the intensive care unit (ICU) with standard serum lactate elution treatments after surgery instead of the operation room or general ward;\n3. availability of complete preoperative, intraoperative, and postoperative data;\n4. the peak serum lactate level in 24 hours after surgery \\>3.250 mmol\u002FL.\n\nExclusion Criteria:\n\n1. a history of surgical treatment of any upper abdominal lesions before the current hospital admission;\n2. the minimum mean arterial pressure \\\u003C65 mmHg during the operation;\n3. without written informed consents for the perioperative situation and related studies.","ALL","18 Years",{"count":69,"type":70},297,"ESTIMATED","INTERVENTIONAL",[73],"NA","Intra-abdominal infection is one of the most serious complications after pancreatic resection. The preventive use of antibiotics intraoperatively could reduce the incidence rate of postoperative intra-abdominal infection. According to the previous retrospective study, changes of serum lactate level on postoperative day1 could predict the incidence rate of postoperative intra-abdominal infection. This prospective RCT is to further validate and promote the findings and conclusion.",[76,77,78],"Postoperative Infection","Lactate","Antibiotics",[80,81,82,83,84],"Serum lactate","Postoperative intra-abdominal infection","Preventive usage","Advanced antibioties","Strategy","2021-09-21",{"date":87,"type":88},"2021-09-27","ACTUAL",{"date":90,"type":88},"2021-07-01",{"date":92,"type":70},"2026-07-01",{"name":5,"class":6},1]