[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615106":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":30,"responsibleParty":48,"collaborators":18,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":18,"enrollmentInfo":60,"targetDuration":18,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":18,"overallStatus":32,"whyStopped":18,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Rush University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PRISM Program","EXPERIMENTAL","This is a novel, remotely delivered, self-tailored intervention for post-anti-obesity medication discontinuation weight management.",[13],"Behavioral: PRISM Program",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual Care","NO_INTERVENTION","Participants will continue to receive their regular, usual primary care.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"BEHAVIORAL","This is a novel, remotely delivered, self-tailored intervention for post-anti-obesity medication discontinuation weight management. The program incorporates standard-of-care behavioral intervention strategies for weight control to improve routine self-weighing, dietary self-monitoring, and increasing physical activity. The program includes an enhanced focus on strategies to reduce food cue reactivity. The program includes six monthly one-on-one sessions between study staff and participants, asynchronous online check-ins weekly for 12 weeks, and bi-weekly for 12 weeks.",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Melissa M Crane, PhD","CONTACT","312-942-1282","melissa_m_crane@rush.edu",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Chicago","Illinois","60130","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-87.65005,41.85003,{"lat":42,"lon":41},[45],{"name":46,"role":27,"phone":28,"phoneExt":18,"email":47},"Melissa Crane","crane_lab@rush.edu",{"type":49,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100615106","primary-care-strategies-for-weight-management-prism-study-100615106",false,"NCT07288294","PRImary Care Strategies for Weight Management (PRISM) Study","Primary-Care Strategies to Enhance Weight Management (PRISM) After Discontinuation of Anti-Obesity Medications","PRISM","Inclusion Criteria:\n\n1. For run-in: prescribed liraglutide, semaglutide, or tirzepatide or newer medication approved by the FDA for long-term use for obesity treatment for the purpose of weight managment by a primary care provider at Rush University System for Health and have received at least one dose of the medication concurrent with enrollment in the study.\n2. For randomization: discontinue their prescribed anti-obesity medication.\n3. Age 18+\n\nExclusion Criteria:\n\n1. Not fluent in English\n2. Diagnosis of diabetes (type 1 or type 2)\n3. Current or planned pregnancy\n4. Bariatric surgery in the past 2 years or planned bariatric surgery.\n5. Body mass index ≥60 kg\u002Fm2, due to increased injury risk with exercise\n6. Body weight ≥ 375 pounds (scale capacity with a margin for regain)\n7. No access to home WIFI or a smartphone with data available\n8. Medical contraindications to treatment, including significant cognitive impairment, active substance abuse based on the World Health Organization's ASSIST screener, or serious medical illness (e.g., stage 3 or 4 heart failure, cancer, renal failure, etc.)\n9. Concurrent engagement with other behavioral treatments for obesity (for randomized phase only).\n10. Medication obtained from online\u002Fcompound pharmacies or prescription from specialty clinic without a prescription from primary care team at the time of enrollment\n11. Another member of the household is enrolled in the study","ALL","18 Years",{"count":61,"type":62},214,"ESTIMATED","INTERVENTIONAL",[65],"NA","The goal of this clinical trial pilot is to determine the feasibility of an intervention to enhance weight management in patients who have stopped taking anti-obesity\u002Fweight management medications in primary care. The main questions it aims to answer are:\n\n* Can patients be recruited into the study efficiently?\n* Is the program acceptable to patients?\n* Can the study be conducted efficiently?\n\nThe new program will be compared to usual care.",[68],"Obesity","2026-06-15",{"date":71,"type":72},"2026-06-17","ACTUAL",{"date":74,"type":62},"2026-06-02",{"date":76,"type":62},"2028-04-01",{"name":5,"class":6},1]