[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557827":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":33,"responsibleParty":135,"collaborators":18,"id":138,"slug":139,"hasResults":140,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":140,"sex":146,"minAge":147,"maxAge":18,"enrollmentInfo":148,"targetDuration":18,"studyType":151,"phases":152,"briefSummary":154,"conditions":155,"keywords":18,"overallStatus":36,"whyStopped":18,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":166},{"fullName":5,"class":6},"University of Rochester","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Prophylactic Catheter-based VT Ablation","EXPERIMENTAL","Subjects receive catheter-based ventricular tachycardia (VT) ablation within 3 months of primary ICD implantation.",[13],"Procedure: Prophylactic Catheter-based VT Ablation",{"label":15,"type":16,"description":17,"interventionNames":18},"Continued Medical Management","NO_INTERVENTION","Subjects undergo continued medical management after primary ICD implantation without prophylactic VT ablation.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"PROCEDURE","Prophylactic Catheter-based VT Ablation refers to a treatment strategy where participants undergo a procedure known as catheter-based ventricular tachycardia (VT) ablation shortly after receiving their primary implantable cardioverter defibrillator (ICD).",[9],[25,30],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Ilan Goldenberg, MD","CONTACT","585-275-5391","Ilan_Goldenberg@URMC.Rochester.edu",{"name":31,"role":27,"phone":18,"phoneExt":18,"email":32},"Misty Ra-Amari, 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Bonnet","a.bonnet@chu-tours.fr",{"name":91,"role":57,"phone":18,"phoneExt":18,"email":18},{"facility":99,"status":36,"city":100,"state":18,"zip":18,"country":63,"countryCode":64,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Centre Hospitalier Universitaire de Bordeaux","Pessac",{"type":43,"coordinates":102},[103,104],-0.6324,44.80565,{"lat":104,"lon":103},[107,111,115],{"name":108,"role":27,"phone":109,"phoneExt":18,"email":110},"Frederic Sacher, MD","05.57.82.08.34","secretariat.consult-cardio2@chu-bordeaux.fr",{"name":112,"role":27,"phone":113,"phoneExt":114,"email":18},"Fabrice Blard","05.25.35.20.74","Poste 52074",{"name":108,"role":57,"phone":18,"phoneExt":18,"email":18},{"facility":117,"status":36,"city":118,"state":18,"zip":18,"country":119,"countryCode":120,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Unidad de Arritimias, Hospital Clínic Barcelona","Barcelona","Spain","ES",{"type":43,"coordinates":122},[123,124],2.15899,41.38879,{"lat":124,"lon":123},[127,131,134],{"name":128,"role":27,"phone":129,"phoneExt":18,"email":130},"Ivo Roca Luque, MD","+34 932274350","iroca@clinic.cat",{"name":132,"role":27,"phone":129,"phoneExt":18,"email":133},"Anna Comellas","COMELLAS@clinic.cat",{"name":128,"role":57,"phone":18,"phoneExt":18,"email":18},{"type":57,"investigatorFullName":136,"investigatorTitle":137,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Ilan Goldenberg","Ilan Goldenberg, MD, Professor of Medicine","100557827","primary-preventive-ventricular-tachycardia-ablation-in-high-risk-patients-who-receive-a-prophylactic-implantable-cardioverter-defibrillator-100557827",false,"NCT06543173","Primary Preventive Ventricular Tachycardia Ablation In High-Risk Patients Who Receive A Prophylactic Implantable Cardioverter Defibrillator","Primary Preventive Ventricular Tachycardia Ablation In High-Risk Patients Who Receive A Prophylactic Implantable Cardioverter Defibrillator (PRIMARY PREVENT-VT TRIAL)","PREVENT-VT","Inclusion Criteria:\n\n* Age ≥ 18 years (no upper age limit)\n* Willing and able to provide informed consent\n* Candidate for a primary prevention ICD\u002FCRT-D per ESC guidelines17\n* Ischemic cardiomyopathy (ICM) with left ventricular ejection fraction (LVEF) ≤ 35%\n* Willing and able to receive an ICD\n* Willing and able to undergo catheter-based VT ablation\n\nOne or more of the following:\n\n* MADIT-ICD Benefit Score \\>75\n* History of nonsustained ventricular tachycardia (NSVT)\n* Multiple premature ventricular complexes (PVCs ≥10%)\n\nExclusion Criteria:\n\n* Existing ICD or CRT-D\n* History of sustained VT or VF\n* Chronic renal failure requiring hemodialysis\n* Coronary revascularization within the past 3 months\n* ST-Elevation MI within the past 3 months\n* Participation in concurrent clinical trials without approval from the Coordination Center (observational registries are allowed with approval)\n* Currently pregnant or planning to become pregnant in the near future\n* Inability or unwillingness to adhere to the study protocol\n* Inability or unwillingness to provide informed consent for participation\n* Life expectancy \\\u003C 1 year","ALL","18 Years",{"count":149,"type":150},62,"ESTIMATED","INTERVENTIONAL",[153],"NA","This prospective, multicenter, open-label, randomized-controlled trial compares two treatment strategies in high-risk ischemic cardiomyopathy (ICM) patients referred for primary ICD implantation. Participants will be randomized to receive either prophylactic VT ablation within three months of ICD implantation or continued medical management. The primary objective is to assess the efficacy of preventive VT ablation versus medical management in reducing VT arrhythmia burden.",[156],"Heart Failure","2026-05-14",{"date":159,"type":160},"2026-05-19","ACTUAL",{"date":162,"type":160},"2026-01-22",{"date":164,"type":150},"2030-08-01",{"name":5,"class":6},5]