[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602753":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":29,"centralContacts":41,"locations":47,"responsibleParty":62,"collaborators":10,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":10,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":10,"maxAge":10,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":84,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Al-Azhar University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"study group",null,"Patients with biopsy proven oral squamous cell carcinoma with the edition T1or T2 N0 based on TNM staging by American Joint cancer center AJCC 8th edition",[13,14],"Diagnostic Test: MRI","Diagnostic Test: Histo-Pathological examination of the resected tumor tissues",[16,23],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DIAGNOSTIC_TEST","MRI","pre-operative MRI scan",[9],[22],"index test",{"type":17,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"Histo-Pathological examination of the resected tumor tissues","histo-pathological examination of the resected tumor tissues with the lymph nodes involved to determine the pathological depth of invasion",[9],[28],"Reference test",[30,34,37,39],{"name":31,"affiliation":32,"role":33},"Wael A ElMohandes, PhD","oral and maxillofacial surgery, Faculty of Dental Medicine, Al-Azhar University","STUDY_DIRECTOR",{"name":35,"affiliation":32,"role":36},"Ahmed M Alfar, PhD","STUDY_CHAIR",{"name":38,"affiliation":32,"role":36},"Mohamed A Mohamed, PhD",{"name":40,"affiliation":32,"role":36},"Mohamed AW Amin, PhD",[42],{"name":43,"role":44,"phone":45,"phoneExt":10,"email":46},"Islam M Ali, MSc","CONTACT","+201274454102","islamelayat@gmail.com",[48],{"facility":49,"status":10,"city":50,"state":10,"zip":10,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"AL Sayed Galal Hospital Al-Azhar University","Cairo","Egypt","EG",{"type":54,"coordinates":55},"Point",[56,57],31.24967,30.06263,{"lat":57,"lon":56},[60],{"name":61,"role":44,"phone":45,"phoneExt":10,"email":46},"Islam M Ali",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Islam Mohamed Mohamed Ali","Assistant Lecturer","100602753","primary-tumor-depth-of-invasion-and-lymph-node-management-in-oral-squamous-cell-carcinoma-100602753",false,"NCT07127614","Primary Tumor Depth of Invasion and Lymph Node Management in Oral Squamous Cell Carcinoma","The Relationship Between Primary Tumor Depth of Invasion and Neck Lymph Nodes Management in T1T2N0 Oral Cavity Squamous Cell Carcinomas","Inclusion Criteria:\n\n* Patients with biopsy-proven oral squamous cell carcinoma with the edition T1or T2 N0 based on TNM staging by the American Joint Cancer Center AJCC 8th edition\n* The primary tumor has a depth of invasion (DOI) greater than 4 mm\n* Clinical N0 status confirmed by reasonable parameters includes computed tomography CT, MRI, -Ultrasonography,( US fine needle aspiration in suspected lymph nodes )\n* The primary tumor must be reliably resected to a clear margin without the need for entry of the neck for reconstruction\n\nExclusion Criteria:\n\n* Patients with T3T4 OCSCC\n* Proven or suspected positive neck node\n* Patient with distant metastasis\n* Patient with gross injury to the neck that precludes proper surgical dissection.\n* Patient with a history of radiotherapy to the neck\n* Recurrent cases of OCSCC or recurrent node disease\n* Patient with previous neck node biopsy or previous neck dissection\n* Patient with a medical condition or performance that interferes with the surgical intervention as judged by the specialist physician","ALL",{"count":75,"type":76},25,"ESTIMATED","OBSERVATIONAL","To evaluate the diagnostic accuracy of preoperative MRI in the determination of the primary tumor depth of invasion (DOI) as a predictor factor in neck lymph nodes management in T1T2N0 oral cavity squamous cell carcinomas as compared to the pathological depth of invasion",[80],"Squamous Cell Carcinoma Mouth",[82,18,83],"squamous cell carcinoma","diagnostic accuracy","NOT_YET_RECRUITING","2025-08-14",{"date":87,"type":88},"2025-08-17","ACTUAL",{"date":90,"type":76},"2025-08-10",{"date":92,"type":76},"2026-01",{"name":5,"class":6},1]