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All interventions will be conducted before and after surgery.\n\nStandardised assessment tools will guide the frequency, intensity, duration, type, volume, and progression of the multimodal interventions, with the potential for the intervention(s) to be stepped-up or stepped-down based on individual patient needs",[13,14,15,16,17,18,19,20,21,22,23],"Behavioral: Preoperative Exercise","Behavioral: Postoperative Exercise","Dietary Supplement: Preoperative Nutrition","Dietary Supplement: Postoperative Nutrition","Behavioral: Preoperative Psychology","Behavioral: Postoperative Psychology","Other: Preoperative Nursing","Other: Postoperative Nursing","Behavioral: Preoperative Peer Support Group","Behavioral: Postoperative Peer Support Group","Other: Usual Care",{"label":25,"type":26,"description":27,"interventionNames":28},"Usual care alone (Control Group)","ACTIVE_COMPARATOR","Participants allocated to the control group will only receive usual care according to their health care team, which may consist of advice on smoking cessation, reduction of alcohol intake, nutritional counselling, and medical optimisation in the preoperative anaesthetic clinic visits. 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The use of any additional service will be recorded to inform the comprehensive cost analysis (linked to PBS and MBS data).",[23],[30,36,39,44,47,51,54,59,63,67,70],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"BEHAVIORAL","Preoperative Exercise","Aerobic, Endurance, Respiratory, Muscle Strength, Education",[9],null,{"type":31,"name":37,"description":33,"armGroupLabels":38,"otherNames":35},"Postoperative Exercise",[9],{"type":40,"name":41,"description":42,"armGroupLabels":43,"otherNames":35},"DIETARY_SUPPLEMENT","Preoperative Nutrition","Malnutrition screening, Weight monitoring, Symptom management, Dietetic counselling, Nutrition support",[9],{"type":40,"name":45,"description":42,"armGroupLabels":46,"otherNames":35},"Postoperative Nutrition",[9],{"type":31,"name":48,"description":49,"armGroupLabels":50,"otherNames":35},"Preoperative Psychology","CBT skills, Skills training, Emotional validation, Behavioural activation, 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Surgery (CRS) with or without HIPEC, or concurrent surgery for metastatic disease\n* Cognitive impairment such that they are unable to provide informed consent","ALL","18 Years",{"count":449,"type":450},564,"ESTIMATED","INTERVENTIONAL",[453],"NA","Objectives:\n\nThe primary aim of this project is to establish the effectiveness of an individualised stepped, multidisciplinary intervention, including education and peer support group, delivered via a virtual multimodal (p)rehabilitation hub, in reducing postoperative complications within 30-days following colorectal cancer surgery, compared to usual care alone.\n\nThe secondary aims will be to obtain data on the likely difference in key outcomes including:\n\n(i) Quality of life (EORTC QLQ-C30 and QLQ-CR29) (ii) Number of days at home within 30, 90 and 365 days after surgery (DAH-30, 90, 365) (iii) Quality of recovery (QoR-15) (iv) Cost-effectiveness (v) Implementation metrics (RE-AIM)\n\nOur hypothesis is that the PRIORITY-CONNECT 2 intervention will be more effective in reducing postoperative complications and more cost-effective than usual care.\n\nStudy design:\n\nPragmatic Randomised Type I Hybrid Effectiveness-Implementation Trial.\n\nPlanned sample size:\n\nTo achieve the primary aim, 564 participants will provide 90% power to detect a 15% difference in 30-day postoperative complication rates between the intervention and control groups. The sample size calculation accounts for up to 10% loss to follow-up, 5% non-compliance and a two-side alpha of 0.05.\n\nSelection criteria:\n\nA sample of 564 participants undergoing colorectal cancer surgery including open, laparoscopic or robotic-assisted surgery (mostly, anterior resection, sigmoid colectomy, hemicolectomy, total proctocolectomy, subtotal colectomy, total colectomy) at sites throughout Australia will be included. These are common colorectal cancer surgeries performed at the participating centres. All the surgeons involved in this study have clinical appointments in their respective hospitals.\n\nInclusion: Adults aged ≥18 years undergoing elective major surgery for colon or rectal cancer with curative intent; and consulting a colorectal surgeon at least 1 week prior to scheduled surgery.\n\nExclusion: Patients undergoing Pelvic Exenteration (PE), Cytoreductive Surgery (CRS) with or without HIPEC, or concurrent surgery for metastatic disease; or cognitive impairment such that they are unable to provide informed consent.\n\nStudy Procedure:\n\nParticipant's treating team will screen and provide an information sheet about the trial to consecutive patients. Interested patients will be contacted by a study researcher to discuss the trial further, answer any questions, confirm eligibility against the inclusion and exclusion criteria, and consent patients. Consenting patients will undergo baseline assessment and be randomised to a virtual multimodal hub (Intervention group) or usual care alone (Control group). The intervention will include the delivery of usual care and evidence-based exercise, nutritional, psychological and nursing interventions, and \u002F or group-delivered peer support. All interventions will be conducted before and after surgery.\n\nDuration of the Study:\n\nApproximately 60 months.\n\nFunding:\n\nMedical Research Future Fund (MRFF) 2023 Early and Mid-Career Researchers (Application ID: 2031563).\n\nSponsor:\n\nThe University of Sydney.",[456,457],"Colorectal Cancer","Colorectal Neoplasms",[459,456,460,461,462,463,464,465,466,467],"Prehabilitation","Surgery","Surgical Outcomes","Randomised Controlled Trial","Virtual Rehabilitation","Virtual Prehabilitation","Multidisciplinary","Virtual Care","Rehabilitation","2026-05-18",{"date":470,"type":471},"2026-05-20","ACTUAL",{"date":473,"type":471},"2025-10-15",{"date":475,"type":450},"2028-07-30",{"name":5,"class":6},31]