[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577037":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":40,"centralContacts":44,"locations":53,"responsibleParty":67,"collaborators":10,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":10,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":10,"studyType":85,"phases":10,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":55,"whyStopped":10,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Jagiellonian University","OTHER",[8,16,19],{"label":9,"type":10,"description":10,"interventionNames":11},"Polycystic ovary syndrome (PCOS)+ insulin resistance (IR)",null,[12,13,14,15],"Diagnostic Test: Measurement of interleukin-6 (il-6) concentration in blood serum","Diagnostic Test: Measurement of fasting tumor necrosis factor α (TNF-α) concentration","Diagnostic Test: Measurement of interleukin-18 (il-18) concentration","Diagnostic Test: Measurement of interleukin-4 (il-4) concentration",{"label":17,"type":10,"description":10,"interventionNames":18},"Polycystic ovary syndrome (PCOS)+ no insulin resistance (IR)",[12,13,14,15],{"label":20,"type":10,"description":10,"interventionNames":21},"No PCOS",[12,13,14,15],[23,28,32,36],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DIAGNOSTIC_TEST","Measurement of interleukin-6 (il-6) concentration in blood serum","Measurement of fasting interleukin-6 (il-6) concentration in fasting venous blood serum",[20,9,17],{"type":24,"name":29,"description":30,"armGroupLabels":31,"otherNames":10},"Measurement of fasting tumor necrosis factor α (TNF-α) concentration","Measurement of fasting tumor necrosis factor α concentration in fasting venous blood serum",[20,9,17],{"type":24,"name":33,"description":34,"armGroupLabels":35,"otherNames":10},"Measurement of interleukin-18 (il-18) concentration","Measurement of interleukin-18 (il-18) concentration in fasting venous blood serum",[20,9,17],{"type":24,"name":37,"description":38,"armGroupLabels":39,"otherNames":10},"Measurement of interleukin-4 (il-4) concentration","Measurement of interleukin-4 (il-4) concentration in fasting venous blood plasma",[20,9,17],[41],{"name":42,"affiliation":5,"role":43},"Kazimierz Pityński, Prof., Ph.D., M.D.","STUDY_CHAIR",[45,50],{"name":46,"role":47,"phone":48,"phoneExt":10,"email":49},"Iwona Gawron, Ph.D., M.D.","CONTACT","+48 124248570","iwona.gawron@uj.edu.pl",{"name":51,"role":47,"phone":10,"phoneExt":10,"email":52},"Robert Jach, Prof., Ph.D., M.D.","jach@cm-uj.krakow.pl",[54],{"facility":5,"status":55,"city":56,"state":10,"zip":10,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"RECRUITING","Krakow","Poland","PL",{"type":60,"coordinates":61},"Point",[62,63],19.93658,50.06143,{"lat":63,"lon":62},[66],{"name":46,"role":47,"phone":10,"phoneExt":10,"email":49},{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Iwona Magdalena Gawron","PhD, MD, Principal Investigator","100577037","pro--and-anti-inflammatory-cytokines-in-pcos-100577037",false,"NCT06793085","Pro- and Anti-inflammatory Cytokines in PCOS","Assessment of the Concentrations of Pro- and Anti-inflammatory Cytokines and Their Association With the Metabolic Profile of Women With PCOS","Inclusion Criteria:\n\n* women aged 18-45 years\n\nExclusion Criteria:\n\n* previous removal of at least one ovary\n* treated diabetes of any type\n* diagnosed and treated metabolic diseases\n* diagnosed and treated autoimmune diseases\n* diagnosed and treated autoinflammatory diseases",true,"FEMALE","18 Years","45 Years",{"count":83,"type":84},100,"ESTIMATED","OBSERVATIONAL","The study will involve measurements and comparisons of the concentrations of pro-inflammatory cytokines: IL-6, TNF-α, IL-18, as well as anti-inflammatory cytokine IL-4 in women with polycystic ovary syndrome (PCOS) and insulin resistance, women with polycystic ovary syndrome without carbohydrate metabolism disorders, and women without PCOS (control group).",[88,89],"Reproductive Age","PCOS (Polycystic Ovary Syndrome)",[91,92,93,94,95],"menstrual disorders","chronic inflammation","insulin resistance","metabolic syndrome","Polycystic Ovary Syndrome","2026-03-17",{"date":98,"type":99},"2026-03-18","ACTUAL",{"date":101,"type":99},"2025-01-20",{"date":103,"type":84},"2026-12-31",{"name":5,"class":6},1]