[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548631":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":29,"responsibleParty":50,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":75,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University of Vienna","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"storage buffer standardisation",null,"Identifying the most effective storage buffer for preserving protein integrity during the transportation of fecal samples from collection to processing sites, is essential for establishing consistent sample collection protocols, particularly for large-scale human fecal proteomic studies. Achieving consistency in sample collection is crucial for enabling individuals to have their gut health assessed via metaproteomics, unlocking the potential for personalized medicine and therapeutic interventions based on microbial communities.",{"label":13,"type":10,"description":14,"interventionNames":10},"inter- and intra-individual variability","the aim is to explore the inter- and intra-individual variability observed in gut microbiome composition and functions from a proteomic perspective. Understanding inter-individual variability differences is crucial for personalized medicine. Recognizing and characterizing intra-individual variability is essential for accurately interpreting research findings, particularly in longitudinal studies or clinical monitoring scenarios. This study aims to elucidate these variabilities using proteomic data from volunteers' fecal samples, shedding light on the variables detected in the gut microbiome and providing insights into its dynamic nature",[16],{"name":17,"affiliation":5,"role":18},"Giacomo Carta, PhD","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"David Gomez Varela PhD. Senior Scientist, PhD","CONTACT","1427755361","david.gomez.varela@univie.ac.at",{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},"Ranjith Kumar Ravi Kumar PhD- postdoc, PhD","1427755318","ranjith.kumar.ravi.kumar@univie.ac.at",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"UVienna","RECRUITING","Vienna","State of Vienna","1090","Austria","AT",{"type":39,"coordinates":40},"Point",[41,42],16.37208,48.20849,{"lat":42,"lon":41},[45,47],{"name":46,"role":22,"phone":23,"phoneExt":10,"email":24},"David Gomez Varela, PhD",{"name":48,"role":22,"phone":49,"phoneExt":10,"email":28},"Ranjith Kumar Ravi Kumar, PhD","+43142-775-5318",{"type":18,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Giacomo Carta","Postdoc","100548631","probing-the-efficacy-of-commercial-stage-storage-buffers-and-evaluating-gut-metaproteome-variability-between-individuals-100548631",false,"NCT06423508","PRObing The Efficacy of Commercial Stage Storage Buffers and Evaluating Gut Metaproteome Variability Between Individuals","PROTEGI","Inclusion Criteria:\n\n* agreeing to participate after signing the informed consent form and\n* being 18-70 years old.\n\nExclusion Criteria:\n\n* take antibiotics during the previous 1 month\n* had undergone gastrointestinal surgery",true,"ALL","18 Years","70 Years",{"count":65,"type":66},52,"ESTIMATED","OBSERVATIONAL","The study aims to assess the effectiveness of various commercial and non-hazardous buffers for the storage of human gut fecal samples over time. This evaluation will be conducted by comparing the performance of these buffers against directly frozen samples using metaproteomic analysis. The study is motivated by the need for standardized protocols for sample preservation in metaproteomic research, particularly focusing on protein preservation in fecal samples. By investigating proteomic, taxonomic, and functional identifications, the research seeks to provide insights into the reliability of these buffers as storage solutions. Additionally, the study plans to explore inter- and intra-individual variabilities at the proteome level by periodically collecting fecal samples from volunteers, complementing existing knowledge in metaproteomics. Overall, the study addresses a critical gap in the field and has the potential to enhance reproducibility and comparability across metaproteomic studies",[70,71,72,73,74],"Gut Microbiome","Buffer","Methodology Study","Fecal Microbiota","Variability",[76,77,78,79,80,81],"storage buffer","fecal samples","human gut microbiome","metaproteomics","intra-individual variability","inter-individual variability","2025-03-24",{"date":84,"type":85},"2025-03-25","ACTUAL",{"date":87,"type":85},"2024-12-03",{"date":89,"type":66},"2025-09-30",{"name":5,"class":6},1]