[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631995":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":53,"collaborators":26,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":26,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":26,"overallStatus":75,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Wecare Probiotics Co., Ltd.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Probiotic group","EXPERIMENTAL","Pasteurized Akkermansia muciniphila Akk11 capsule, 34 billion TFU\u002Fday",[13],"Dietary Supplement: Probiotic",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo group","PLACEBO_COMPARATOR","Placebo capsule, one capsules\u002Fday",[19],"Dietary Supplement: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Probiotic","The trial phase of this study lasted 12 weeks, and each patient will make 4 visits (week 0, week 4, week 8， week 12)",[9],null,{"type":22,"name":28,"description":24,"armGroupLabels":29,"otherNames":26},"Placebo",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Ying Wu, doctor","CONTACT","18639283502","yingwu@haust.edu.cn",[37],{"facility":38,"status":26,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"The School of Food and Bioengineering, Henan University of Science and Technolog","Luoyang","Henan","471000","China","CN",{"type":45,"coordinates":46},"Point",[47,48],112.43684,34.67345,{"lat":48,"lon":47},[51],{"name":32,"role":33,"phone":34,"phoneExt":52,"email":35},"+86",{"type":54,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100631995","probiotic-for-weight-management-in-overweight-and-obese-adults-100631995",false,"NCT07507929","Probiotic for Weight Management in Overweight and Obese Adults","Effectiveness and Safety of Inactivated Akkermansia Muciniphila Akk11 (34B) on Weight and Energy Metabolism in Overweight and Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial","Inclusion Criteria:\n\n1. Body mass index (BMI) ≥ 24 kg\u002Fm²;\n2. Able and willing to provide written informed consent;\n3. Willing to comply with the study protocol and required restrictions, including adherence to a low-carbohydrate, energy-restricted diet;\n4. No intention to conceive from 14 days prior to screening until 6 months after study completion, and agreement to use effective contraception during this period\n\nExclusion Criteria:\n\n1. Recent use of products with similar functions to the investigational product that may interfere with study outcomes;\n2. History of psychiatric or neurological disorders, celiac disease, lactose intolerance, or known allergies;\n3. Pregnant or breastfeeding women, or those planning to become pregnant during the study period;\n4. Diagnosis of irritable bowel syndrome (IBS), ulcerative colitis, liver cirrhosis, or diabetes mellitus;\n5. Use of antibiotics within 3 months prior to screening;\n6. Inability to comply with the study protocol, including failure to take the investigational product as required or attend scheduled follow-up visits;\n7. Smoking more than 10 cigarettes per day;\n8. Any other condition that, in the opinion of the investigator, would make the participant unsuitable for the study.",true,"ALL","18 Years","65 Years",{"count":67,"type":68},76,"ESTIMATED","INTERVENTIONAL",[71],"NA","To evaluate the impact of pasteurized Akkermansia muciniphila Akk11 capsules versus placebo on body composition (including body weight, BMI, body fat percentage, waist-to-hip ratio, wrist circumference, visceral fat area, and basal metabolic rate) and serum lipid parameters (TC, LDL-C, HDL-C, and TG) in overweight and obese adults.",[74],"Obesity","NOT_YET_RECRUITING","2026-03-27",{"date":78,"type":79},"2026-04-02","ACTUAL",{"date":81,"type":68},"2026-03-20",{"date":83,"type":68},"2026-12-30",{"name":5,"class":6},1]