[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643989":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":32,"locations":33,"responsibleParty":54,"collaborators":58,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":32,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":88,"whyStopped":32,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Reading","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ecologic® Barrier","EXPERIMENTAL","Participants will consume one sachet of Ecologic® Barrier powder(1x10\\^10 CFU\u002Fday), mixed in warm water with a meal. The sachets can be stored at room temperature.",[13],"Dietary Supplement: Ecologic® Barrier",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo powder","PLACEBO_COMPARATOR","A placebo matched for packaging, visual appearance, smell, and taste will be given.\n\nSimilar to the instructions on how to take the probiotic, subjects will consume one sachet per day, kept at room temperature, mixed into warm water with a meal.",[19],"Dietary Supplement: Placebo powder",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Ecologic® Barrier (1x1010 CFU\u002Fday).",[9],[26],"Probiotics",{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Matched placebo",[15],[31],"placebo",null,[34],{"facility":35,"status":32,"city":36,"state":32,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"School of Psychology and Clinical Languages","London","RG6 6UR","United Kingdom","UK",{"type":41,"coordinates":42},"Point",[43,44],-0.12574,51.50853,{"lat":44,"lon":43},[47,52],{"name":48,"role":49,"phone":50,"phoneExt":32,"email":51},"Vanessa Sofia Amaral Lopes Simoes","CONTACT","0118 987 5123","v.amarallopessimoes@pgr.reading.ac.uk",{"name":48,"role":53,"phone":32,"phoneExt":32,"email":32},"SUB_INVESTIGATOR",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Daniel Lamport","Associate Professor",[59],{"name":60,"class":61},"Winclove Probiotics B.V.","INDUSTRY","100643989","probiotics-for-depressive-symptomatology-and-neural-activity-100643989",false,"NCT07667530","Probiotics for Depressive Symptomatology and Neural Activity.","The Acute and Chronic Effects of Ecologic® Barrier on Depressive Symptoms and Neural Activation.","PRODAN","Inclusion Criteria:\n\n* Mild to moderate depression symptoms (BDI-II 12-28)\n* Males and females\n* Age range will be 25-40 years\n* Right-handed participants only (required for EEG)\n\nExclusion Criteria:\n\n* Taking antidepressants (up to 2 months prior to inclusion)\n* Undergoing psychological treatment in the form of counselling, therapy or similar (up to 1 month prior to inclusion)\n* Any diagnosed chronic medical condition (e.g. diabetes) or psychiatric illness.\n* Use of antibiotics or laxatives (up to 3 months prior to inclusion)\n* Use of probiotics and\u002For prebiotics (up to 1 month prior to inclusion)\n* Enrolled in any other clinical trial (up to 1 month prior to inclusion)\n* Following restrictive and\u002For unbalanced diets\n* Smoking\n* Continuous use of a weight-loss medication for more than one month prior to screening\n* Significant gastrointestinal conditions affecting absorption, including but not limited to: inflammatory bowel disease; total colectomy or bariatric surgery; irritable bowel disease; end-stage renal disease; active cancer or cancer treatment within the past three years","ALL","25 Years","40 Years",{"count":74,"type":75},76,"ESTIMATED","INTERVENTIONAL",[78],"NA","This study aims to investigate the acute and chronic effects of 16-week probiotic supplementation (Ecologic® Barrier) on depressive symptoms and neural activity in those with mild-to-moderate depression.",[81,82,83],"Mild-to-moderate Depression","Neural Activity","Executive Function (Cognition)",[81,85,86,87],"Probiotic Supplementation","Neural Activation","Executive Function","NOT_YET_RECRUITING","2026-06-19",{"date":91,"type":92},"2026-06-25","ACTUAL",{"date":94,"type":75},"2026-07-01",{"date":96,"type":75},"2027-03-01",{"name":5,"class":6},1]