[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589871":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":52,"collaborators":54,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":25,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":79,"whyStopped":25,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Procalcitonin-guided antibiotic management","EXPERIMENTAL","Patients hospitalized in Internal Medicine, Geriatrics, Infectious Disease unit, Pneumology, Semi Intensive Care unit, ICU, Emergency Medicine with clinical and instrumental diagnosis of lower respiratory tract infection (LRTI), randomized in the experimental arm",[13],"Procedure: Procalcitonin-guided antibiotic management",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of care","ACTIVE_COMPARATOR","Patients hospitalized in Internal Medicine, Geriatrics, Infectious Disease unit, Pneumology, Semi Intensive Care unit, ICU, Emergency Medicine with clinical and instrumental diagnosis of lower respiratory tract infection (LRTI), randomized in the control arm",[19],"Procedure: Standard of care",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","After the randomization, PCT plasma concentration will be dosed and repeated every 24 hours and antimicrobial treatment will be withdrawn as soon as the PCT value will decrease \\> 80% of peak value or will fall below 0.25 ng\u002FmL. Patients with a normal baseline PCT value (below 0.25 ng\u002FmL) will start the antimicrobial therapy, as clinically appropriate and PCT plasma concentration will be repeated every 24 hours, as indicated in the protocol. The antimicrobial agents will be managed according to the clinical and radiological evolution of the LRTI.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Patients assigned to the control group will be treated according to the best standard of care and PCT will not be evaluated for the whole duration of the study.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Prof. Luigi Mario Castello","CONTACT","0131206893","luigi.castello@ospedale.al.it",[36],{"facility":37,"status":25,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Clinical Trial Center","Alessandria","Piedmont","15121","Italy","IT",{"type":44,"coordinates":45},"Point",[46,47],8.61007,44.90924,{"lat":47,"lon":46},[50],{"name":37,"role":32,"phone":33,"phoneExt":25,"email":51},"clinicaltrialcenter@ospedale.al.it",{"type":53,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[55],{"name":56,"class":6},"Thermo Fisher Scientific FS","100589871","procalcitonin-aided-antimicrobial-therapy-vs-standard-of-care-100589871",false,"NCT06960044","Procalcitonin Aided Antimicrobial Therapy vs Standard of Care","Procalcitonin Aided Antimicrobial Therapy vs Standard of Care: a Randomized Prospective Clinical Trial","PCT","Inclusion Criteria:\n\n* age ≥18 years;\n* clinical and instrumental diagnosis of LRTI consistent with bacterial origin and requiring antimicrobial treatment;\n* patient hospitalized in Internal Medicine, Geriatrics, Infectious Disease unit, Pneumology, Semi Intensive Care unit, ICU, Emergency Medicine;\n* informed consent provided by the patient.\n\nExclusion Criteria:\n\n* age \\\u003C 18 years;\n* lack of informed consent;\n* severe immunosuppression (other than related to corticosteroid use);\n* concomitant diagnosis of other infections requiring long term antimicrobial therapy (i.e. endocarditis, osteomyelitis)","ALL","18 Years",{"count":68,"type":69},108,"ESTIMATED","INTERVENTIONAL",[72],"NA","Antibiotic resistance is driven by overuse, especially for viral respiratory infections. Procalcitonin (PCT), a biomarker for bacterial infections, helps guide antibiotic therapy more precisely, reducing unnecessary use and improving outcomes. Studies, including large trials and economic models across several countries, show PCT-guided treatment lowers mortality, antibiotic exposure, therapy duration and related complications, potentially reducing hospital costs despite initial testing expenses.",[75],"Lower Respiratory Tract Infection (LRTI)",[77,78],"procalcitonin","procalcitonin-guided antibiotic management","NOT_YET_RECRUITING","2025-05-05",{"date":82,"type":83},"2025-05-07","ACTUAL",{"date":85,"type":69},"2025-06-01",{"date":87,"type":69},"2027-06-01",{"name":5,"class":6},1]